Motif ID: MSX1,2.p2

Z-value: 0.274


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MSX2hg19_v1_chr5_+_174151531_174151694-0.463.6e-01Click!
MSX1hg19_v1_chr4_+_4861371_4861426-0.216.9e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_136501484 0.107 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr6_+_50786438 0.098 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chrX_-_15620191 0.097 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr5_+_59784004 0.094 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr9_-_97356007 0.087 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr11_-_6790187 0.079 NM_001004490
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr4_+_88896838 0.074 SPP1
secreted phosphoprotein 1
chr5_-_160279045 0.074 NM_025153
ATP10B
ATPase, class V, type 10B
chr13_-_99910548 0.072 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr4_+_88896801 0.071 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr10_-_52008312 0.069 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr3_-_137832321 0.064 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr4_+_88896868 0.061 SPP1
secreted phosphoprotein 1
chr1_-_108231122 0.059 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr6_-_51952368 0.059 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr2_-_69098502 0.059 NM_014482
BMP10
bone morphogenetic protein 10
chr4_-_76957139 0.057 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr7_+_141490016 0.055 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr14_-_65409445 0.054 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_+_88896899 0.051 SPP1
secreted phosphoprotein 1
chr1_-_150978879 0.049 NM_001163259
NM_001163260
NM_001040217
FAM63A


family with sequence similarity 63, member A


chr5_+_15500288 0.049 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr5_-_148758787 0.047 NM_014443
IL17B
interleukin 17B
chr19_-_14169970 0.047 NM_001145028
PALM3
paralemmin 3
chr12_+_101188373 0.045 NM_178826
ANO4
anoctamin 4
chr7_-_108142934 0.040 PNPLA8
patatin-like phospholipase domain containing 8
chr9_+_134305532 0.038


chr19_+_36203829 0.036 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr20_+_2276612 0.036 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr3_-_165555167 0.035 BCHE
butyrylcholinesterase
chr7_-_14025826 0.033 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_-_154832187 0.032 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr1_+_196946666 0.030 NM_030787
CFHR5
complement factor H-related 5
chr2_+_103378489 0.029 NM_144632
TMEM182
transmembrane protein 182
chr3_+_52828783 0.028 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr10_-_45474210 0.028 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr1_+_186798031 0.027 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr4_+_71062241 0.026 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr5_+_15500539 0.025 FBXL7
F-box and leucine-rich repeat protein 7
chr18_+_3594056 0.024 FLJ35776
uncharacterized LOC649446
chr3_+_69812620 0.022 NM_001184967
MITF
microphthalmia-associated transcription factor
chr2_-_180427314 0.022 NM_001113398
ZNF385B
zinc finger protein 385B
chr11_-_17191287 0.022 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr2_-_145277879 0.021 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr3_-_165555252 0.021 NM_000055
BCHE
butyrylcholinesterase
chr14_-_73453651 0.020 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr11_-_83393436 0.020 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chrX_-_133792497 0.020 NM_021796
PLAC1
placenta-specific 1
chr6_-_28483563 0.019 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr16_-_21289571 0.019 CRYM
crystallin, mu
chr4_-_186733372 0.019 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr2_+_28718937 0.018 NM_001170585
NM_153021
PLB1

phospholipase B1

chr3_+_69812961 0.018 NM_006722
MITF
microphthalmia-associated transcription factor
chr2_-_134326030 0.018 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr17_-_19651586 0.018 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr20_+_43211219 0.017 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr5_-_36301999 0.017 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr10_+_115511212 0.016 NM_001193434
NM_001193435
NM_024889
C10orf81


chromosome 10 open reading frame 81


chr11_+_61717355 0.016 NM_001139443
NM_004183
BEST1

bestrophin 1

chr1_+_33004771 0.016 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr6_+_16129285 0.015 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr13_-_86373328 0.015 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr14_-_68283293 0.015 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr20_-_49253425 0.015 NM_080829
FAM65C
family with sequence similarity 65, member C
chr14_-_73925259 0.015 NUMB
numb homolog (Drosophila)
chr8_+_21900389 0.014 NM_003867
FGF17
fibroblast growth factor 17
chr6_-_130536417 0.014 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr22_-_25777543 0.014 NM_001135772
LRP5L
low density lipoprotein receptor-related protein 5-like
chr11_+_15133969 0.014 NM_001031853
INSC
inscuteable homolog (Drosophila)
chr9_+_134305476 0.014 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr1_-_190446701 0.013 NM_199051
FAM5C
family with sequence similarity 5, member C
chr6_-_119470336 0.013 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr6_+_54173202 0.013 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr12_+_109554391 0.013 ACACB
acetyl-CoA carboxylase beta
chr1_+_78470593 0.013 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr2_+_65216482 0.013 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr7_+_91924291 0.013


chr9_-_116840551 0.012 AMBP
alpha-1-microglobulin/bikunin precursor
chr8_+_75736771 0.012 NM_015886
PI15
peptidase inhibitor 15
chr1_-_26644755 0.012 NM_145345
UBXN11
UBX domain protein 11
chr21_-_27372461 0.012 APP
amyloid beta (A4) precursor protein
chr6_+_31973358 0.012 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chrX_-_110655384 0.012 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr1_+_204839977 0.012 NFASC
neurofascin
chr17_-_4890920 0.012 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr14_-_73925279 0.012 NM_001005743
NM_001005744
NM_001005745
NM_003744
NUMB



numb homolog (Drosophila)



chr2_-_183387063 0.012 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr7_+_150725502 0.011 NM_007188
ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr3_-_126327397 0.011 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr2_+_84743576 0.011 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chrX_-_48828250 0.011 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr5_-_90610218 0.011 LOC100505994
uncharacterized LOC100505994
chr3_+_130569368 0.011 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr2_-_77749335 0.011 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr1_+_120254418 0.011 NM_006623
PHGDH
phosphoglycerate dehydrogenase
chr9_-_116840460 0.011 AMBP
alpha-1-microglobulin/bikunin precursor
chr8_+_32504250 0.010 NM_013959
NRG1
neuregulin 1
chr17_-_33885106 0.010 NM_001129820
SLFN14
schlafen family member 14
chr10_+_695887 0.010 C10orf108
chromosome 10 open reading frame 108
chr7_-_20256942 0.010 NM_182762
MACC1
metastasis associated in colon cancer 1
chr16_+_53479685 0.010 RBL2
retinoblastoma-like 2 (p130)
chr3_+_187943192 0.010 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_-_120401401 0.009 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr11_-_85469043 0.009 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr2_+_61389628 0.009 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr17_-_66951381 0.009 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr1_+_205473683 0.008 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr2_-_175462428 0.008 WIPF1
WAS/WASL interacting protein family, member 1
chrX_+_16964730 0.008 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr4_-_89205667 0.008 PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr12_-_105627182 0.008 NM_001251905
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr2_-_175499275 0.008 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr5_+_139876504 0.008 ANKHD1
ankyrin repeat and KH domain containing 1
chr10_-_62332666 0.008 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr9_-_116840604 0.008 AMBP
alpha-1-microglobulin/bikunin precursor
chr19_+_49376488 0.008 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr6_-_56507585 0.008 NM_001723
NM_015548
DST

dystonin

chr3_-_195310985 0.008 NM_001647
APOD
apolipoprotein D
chr17_-_15554809 0.008 TRIM16
tripartite motif containing 16
chr12_+_86268072 0.008 NM_006183
NTS
neurotensin
chr16_-_69385656 0.008 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr5_+_36608430 0.008 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_219745243 0.008 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr17_+_68071386 0.007 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr1_-_201915715 0.007 NM_012134
LMOD1
leiomodin 1 (smooth muscle)
chr10_-_126716452 0.007 NM_022802
CTBP2
C-terminal binding protein 2
chr7_-_115670774 0.006 TFEC
transcription factor EC
chr10_+_35484829 0.006 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr2_+_102803432 0.006 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr12_+_7169192 0.006


chr17_+_7743233 0.006 NM_001080424
KDM6B
lysine (K)-specific demethylase 6B
chr21_-_34185943 0.006 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr11_-_101000457 0.006 NM_000926
PGR
progesterone receptor
chr17_+_70117154 0.006 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr14_-_50474237 0.006 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr17_+_70117168 0.006 SOX9
SRY (sex determining region Y)-box 9
chr2_-_231789940 0.006 NM_005683
GPR55
G protein-coupled receptor 55
chr3_-_192635933 0.006 NM_178496
MB21D2
Mab-21 domain containing 2
chr11_-_72463416 0.006 NM_001040118
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chrX_+_129139163 0.006 NM_021946
BCORL1
BCL6 corepressor-like 1
chr7_+_77469446 0.006 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr12_-_21487831 0.006 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr6_+_16129321 0.006 MYLIP
myosin regulatory light chain interacting protein
chr3_-_149095517 0.005 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr19_-_44079609 0.005 XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr3_+_100238063 0.005 TMEM45A
transmembrane protein 45A
chr14_-_73925214 0.005 NUMB
numb homolog (Drosophila)
chr1_+_153330329 0.005 NM_002965
S100A9
S100 calcium binding protein A9
chr5_+_140809957 0.005 PCDHGA12
protocadherin gamma subfamily A, 12
chr1_+_26644380 0.005 NM_001803
CD52
CD52 molecule
chr10_+_114133775 0.005 ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_30706532 0.005 NM_031271
TEX15
testis expressed 15
chr13_-_95131718 0.005 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chrX_-_129519420 0.005 NM_178471
GPR119
G protein-coupled receptor 119
chr10_-_62149487 0.005 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_+_67498391 0.005 MAP2K6
mitogen-activated protein kinase kinase 6
chr3_-_196911001 0.005 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr13_+_103459495 0.005 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr19_+_46171501 0.005 NM_000164
GIPR
gastric inhibitory polypeptide receptor
chr6_+_101846668 0.005 GRIK2
glutamate receptor, ionotropic, kainate 2
chr4_-_89744154 0.005 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr6_-_94129059 0.005 NM_004440
EPHA7
EPH receptor A7
chr3_-_149095333 0.005 TM4SF1
transmembrane 4 L six family member 1
chr9_-_116840545 0.004 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_+_33448597 0.004 NM_017559
FNDC8
fibronectin type III domain containing 8
chr17_+_7792034 0.004 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr3_-_149095458 0.004 TM4SF1
transmembrane 4 L six family member 1
chr22_+_40573879 0.004 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr1_-_149785235 0.004 NM_001123375
HIST2H3D
histone cluster 2, H3d
chr10_+_7745354 0.004 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr20_-_35444558 0.004 KIAA0889
KIAA0889
chr14_+_95623991 0.004 DICER1-AS
DICER1 antisense RNA (non-protein coding)
chr3_+_118892363 0.004 NM_006952
UPK1B
uroplakin 1B
chrX_+_119737743 0.004 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr4_-_24981769 0.004 NM_173463
CCDC149
coiled-coil domain containing 149
chr5_-_59783885 0.004 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_154178525 0.004 TRIM2
tripartite motif containing 2
chr3_+_69915374 0.004 NM_198177
MITF
microphthalmia-associated transcription factor
chr5_+_73109342 0.004 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr1_+_36772696 0.004 NM_024676
SH3D21
SH3 domain containing 21
chr16_-_73092533 0.004 NM_001164766
ZFHX3
zinc finger homeobox 3
chr7_+_30737600 0.004 INMT
indolethylamine N-methyltransferase
chr6_-_25930838 0.004 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chrX_+_153656977 0.003 NM_001183
ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr11_-_27681195 0.003 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr1_-_19217384 0.003 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr7_+_120629444 0.003 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr3_+_183894736 0.003 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr5_-_138210992 0.003 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr12_+_53818864 0.003 AMHR2
anti-Mullerian hormone receptor, type II
chr1_-_169703178 0.003 NM_000450
SELE
selectin E
chr3_-_149095413 0.003 TM4SF1
transmembrane 4 L six family member 1
chr5_-_156536185 0.003 NM_032782
HAVCR2
hepatitis A virus cellular receptor 2
chr1_+_117602909 0.003 TTF2
transcription termination factor, RNA polymerase II
chr8_+_107738239 0.003 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr11_-_115088628 0.003 CADM1
cell adhesion molecule 1
chr5_-_22212873 0.003 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr6_+_31583766 0.002 NM_032955
AIF1
allograft inflammatory factor 1
chr11_-_8832881 0.002 NM_139157
ST5
suppression of tumorigenicity 5
chr5_+_166711842 0.002 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.