Motif ID: NHLH1,2.p2

Z-value: 1.064


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NHLH1hg19_v1_chr1_+_160336856_1603368730.128.2e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_39341126 1.027 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr16_+_330605 0.869 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr6_+_42751155 0.738 FLJ38717
FLJ38717 protein
chr6_-_46138584 0.720 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr11_+_71259465 0.719 NM_005553
KRTAP5-9
keratin associated protein 5-9
chr15_+_76352270 0.689 NM_152335
C15orf27
chromosome 15 open reading frame 27
chr8_+_17014006 0.685 ZDHHC2
zinc finger, DHHC-type containing 2
chr3_+_159943628 0.681 C3orf80
chromosome 3 open reading frame 80
chr11_-_63684315 0.674 NM_173587
RCOR2
REST corepressor 2
chr5_+_76114881 0.664 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr19_+_35521591 0.647 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr15_-_80216004 0.641 ST20
suppressor of tumorigenicity 20
chr3_-_9920471 0.612 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr5_+_76114832 0.578 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr11_-_63684570 0.565 RCOR2
REST corepressor 2
chrX_+_118892544 0.522 NM_001105576
ANKRD58
ankyrin repeat domain 58
chr1_-_85514174 0.522 NM_001253693
NM_018298
MCOLN3

mucolipin 3

chr6_-_109776946 0.511 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr2_+_112812900 0.492 TMEM87B
transmembrane protein 87B
chr2_-_288181 0.490 NM_001002919
FAM150B
family with sequence similarity 150, member B
chr5_+_115298136 0.482 NM_173800
AQPEP
laeverin
chr6_+_36646489 0.481 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr3_-_133614296 0.481 RAB6B
RAB6B, member RAS oncogene family
chr14_-_65879245 0.473 LOC645431
uncharacterized LOC645431
chr3_-_9920633 0.465 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr10_+_17271276 0.459 VIM
vimentin
chr3_-_45187861 0.459 CDCP1
CUB domain containing protein 1
chr17_+_43299277 0.458 NM_005892
FMNL1
formin-like 1
chr17_-_17399494 0.456 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr1_+_20915440 0.455 NM_001785
CDA
cytidine deaminase
chr10_+_17271277 0.453 VIM
vimentin
chr3_+_5229430 0.453 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr2_-_122042767 0.452 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr6_+_42750465 0.446 FLJ38717
FLJ38717 protein
chr10_-_93668625 0.442 FGFBP3
fibroblast growth factor binding protein 3
chr4_-_13549293 0.442 LOC285548
uncharacterized LOC285548
chr1_+_32827797 0.440 NM_052841
TSSK3
testis-specific serine kinase 3
chr2_-_96810775 0.434 DUSP2
dual specificity phosphatase 2
chr17_+_47653176 0.428 NM_007225
NXPH3
neurexophilin 3
chr10_+_17271302 0.424 VIM
vimentin
chr10_+_17271341 0.421 VIM
vimentin
chr2_-_230579198 0.414 NM_139072
DNER
delta/notch-like EGF repeat containing
chr5_-_138739755 0.407 NM_194296
SPATA24
spermatogenesis associated 24
chr14_+_38678594 0.397 SSTR1
somatostatin receptor 1
chr6_-_109777171 0.396 NM_001159291
NM_022765
MICAL1

microtubule associated monoxygenase, calponin and LIM domain containing 1

chr3_+_183948216 0.393 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr12_+_6309475 0.390 NM_001769
CD9
CD9 molecule
chr2_+_29338207 0.388 NM_024692
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr2_+_112812799 0.386 NM_032824
TMEM87B
transmembrane protein 87B
chr10_-_42863435 0.385 LOC441666
zinc finger protein 91 pseudogene
chr6_+_36646455 0.381 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr3_+_119298522 0.379 NM_001125
ADPRH
ADP-ribosylarginine hydrolase
chr8_-_17658711 0.379


chr1_-_212873197 0.375 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr21_+_46293925 0.374


chr17_+_47653474 0.364 NXPH3
neurexophilin 3
chr2_-_160143062 0.363 NM_152528
NM_001128213
NM_001128212
WDSUB1


WD repeat, sterile alpha motif and U-box domain containing 1


chr6_+_3259134 0.360 NM_001128591
NM_001128592
NM_001135750
PSMG4


proteasome (prosome, macropain) assembly chaperone 4


chr17_-_16395084 0.360 FAM211A
family with sequence similarity 211, member A
chr9_+_116111811 0.358 NM_017688
BSPRY
B-box and SPRY domain containing
chr11_+_111411419 0.358 LAYN
layilin
chr6_-_109776942 0.352 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr4_-_174090305 0.344


chrX_+_16964730 0.343 NM_001080975
NM_004726
REPS2

RALBP1 associated Eps domain containing 2

chr6_-_26250832 0.338 NM_021018
HIST1H3J
HIST1H3F
histone cluster 1, H3j
histone cluster 1, H3f
chr1_-_144520918 0.337 LOC728855
uncharacterized LOC728855
chr21_+_34697277 0.335 IFNAR1
interferon (alpha, beta and omega) receptor 1
chr1_+_10057254 0.334 NM_052960
RBP7
retinol binding protein 7, cellular
chr8_+_21881587 0.334 NPM2
nucleophosmin/nucleoplasmin 2
chr7_-_33148897 0.333 NM_203288
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr15_-_60884615 0.333 NM_134262
RORA
RAR-related orphan receptor A
chr10_-_133795447 0.332 BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr6_+_144471631 0.331 NM_003764
STX11
syntaxin 11
chr6_-_109777085 0.328 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_-_212873306 0.325 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr17_+_28256873 0.323 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr12_-_11175169 0.322 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr9_+_140500156 0.318


chr2_+_196521851 0.318 NM_020342
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr11_+_10472223 0.315 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr17_-_7165788 0.315 CLDN7
claudin 7
chr4_-_2420252 0.313 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr17_+_7342688 0.312 NM_004112
FGF11
fibroblast growth factor 11
chr8_-_144512601 0.310 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr3_-_45187843 0.309 CDCP1
CUB domain containing protein 1
chr17_-_31204071 0.308 MYO1D
myosin ID
chr8_-_68658577 0.306 NM_020361
CPA6
carboxypeptidase A6
chr6_-_74079514 0.305 NM_001080507
OOEP
oocyte expressed protein homolog (dog)
chr21_+_37507209 0.304 NM_001236
CBR3
carbonyl reductase 3
chr6_-_90121966 0.302 NM_021244
RRAGD
Ras-related GTP binding D
chr4_+_41362565 0.301 LIMCH1
LIM and calponin homology domains 1
chr19_+_18111923 0.301 NM_001025604
ARRDC2
arrestin domain containing 2
chr15_+_76352323 0.300 C15orf27
chromosome 15 open reading frame 27
chr2_+_191745547 0.300 GLS
glutaminase
chr6_-_90121656 0.300 RRAGD
Ras-related GTP binding D
chrX_+_117629871 0.300 NM_144658
DOCK11
dedicator of cytokinesis 11
chr4_-_140201339 0.297 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr20_-_56884488 0.296 PPP4R1L
protein phosphatase 4, regulatory subunit 1-like
chr6_+_89791510 0.296 PNRC1
proline-rich nuclear receptor coactivator 1
chr1_-_6479880 0.296 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr3_-_45267068 0.294 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr2_+_112813079 0.294 TMEM87B
transmembrane protein 87B
chr1_+_218519576 0.294 TGFB2
transforming growth factor, beta 2
chr4_-_120549827 0.293 NM_001083
PDE5A
phosphodiesterase 5A, cGMP-specific
chr1_+_90098643 0.291 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr9_+_79792318 0.291 NM_001018037
NM_001018038
NM_015186
NM_033305
VPS13A



vacuolar protein sorting 13 homolog A (S. cerevisiae)



chr6_-_109761707 0.291 PPIL6
peptidylprolyl isomerase (cyclophilin)-like 6
chr19_+_38794800 0.291 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr8_+_31497267 0.290 NM_013962
NRG1
neuregulin 1
chr12_-_129308293 0.289 NM_145648
SLC15A4
solute carrier family 15, member 4
chr12_+_133195365 0.289 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr3_-_32022734 0.289 OSBPL10
oxysterol binding protein-like 10
chr3_+_194407412 0.289 FAM43A
family with sequence similarity 43, member A
chr8_+_17013459 0.288 ZDHHC2
zinc finger, DHHC-type containing 2
chr7_-_139168408 0.287 NM_198508
KLRG2
killer cell lectin-like receptor subfamily G, member 2
chr17_-_31204187 0.286 MYO1D
myosin ID
chr7_-_120498009 0.284 TSPAN12
tetraspanin 12
chr1_-_109849613 0.284 NM_001010985
MYBPHL
myosin binding protein H-like
chr1_+_155051263 0.282 NM_004952
EFNA3
ephrin-A3
chr1_-_147931877 0.281 FLJ39739
uncharacterized FLJ39739
chr18_+_23806385 0.281 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr3_+_119298355 0.279 ADPRH
ADP-ribosylarginine hydrolase
chr8_+_104383701 0.278 CTHRC1
collagen triple helix repeat containing 1
chr15_-_74726258 0.278 NM_001146029
NM_003612
SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

chr17_-_7166263 0.277 NM_001185023
NM_001307
CLDN7

claudin 7

chr1_-_6321034 0.276 NM_207370
GPR153
G protein-coupled receptor 153
chr8_+_17013799 0.276 NM_016353
ZDHHC2
zinc finger, DHHC-type containing 2
chr19_-_42569921 0.275 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr17_-_31203889 0.273 NM_015194
MYO1D
myosin ID
chrX_-_9733916 0.273 NM_000273
GPR143
G protein-coupled receptor 143
chr7_+_1097140 0.272 NM_138445
GPR146
G protein-coupled receptor 146
chr15_+_59499021 0.272 NM_033195
LDHAL6B
lactate dehydrogenase A-like 6B
chr5_+_69696805 0.271 SMA4
glucuronidase, beta pseudogene
chr3_-_73673978 0.271 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr12_+_53817638 0.269 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr7_-_124405029 0.269 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_-_84464728 0.269 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr17_-_73874056 0.269 TRIM47
tripartite motif containing 47
chr11_-_63933493 0.269 NM_014067
MACROD1
MACRO domain containing 1
chr16_-_30107492 0.268 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr6_+_17281773 0.268 NM_001143942
RBM24
RNA binding motif protein 24
chr6_-_90121911 0.267 RRAGD
Ras-related GTP binding D
chr9_+_139972195 0.265 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr15_-_80215663 0.264 NM_001100880
NM_001199757
ST20

suppressor of tumorigenicity 20

chr19_+_49109999 0.263 NM_133498
SPACA4
sperm acrosome associated 4
chr19_+_16187047 0.263 NM_003290
TPM4
tropomyosin 4
chr17_-_16395479 0.262 NM_001113567
NM_207387
FAM211A

family with sequence similarity 211, member A

chr9_-_35812143 0.261 NM_001039592
NM_172312
SPAG8

sperm associated antigen 8

chr1_+_161185084 0.260 NM_004106
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr7_+_128577990 0.260 NM_001098629
NM_001098630
NM_001242452
IRF5


interferon regulatory factor 5


chr4_+_37892698 0.259 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr14_-_61115906 0.257 NM_005982
SIX1
SIX homeobox 1
chr9_-_38424422 0.257 NM_001007563
IGFBPL1
insulin-like growth factor binding protein-like 1
chr8_-_105601234 0.256 NM_001135703
NM_013437
LRP12

low density lipoprotein receptor-related protein 12

chr11_+_17373138 0.255 NM_001202439
B7H6
B7 homolog 6
chr19_+_18118921 0.255 NM_015683
ARRDC2
arrestin domain containing 2
chr16_-_90085786 0.253 NM_001042610
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr7_+_48128738 0.252 NM_003364
UPP1
uridine phosphorylase 1
chr1_-_212873104 0.251 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr4_-_6911373 0.250


chr1_+_212459262 0.250 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr9_+_103235634 0.249 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr6_+_139456240 0.247 NM_016217
HECA
headcase homolog (Drosophila)
chr6_-_109776832 0.247 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr6_+_125474800 0.246 NM_001003396
NM_001003397
NM_003287
TPD52L1


tumor protein D52-like 1


chr3_+_5229484 0.245 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr22_-_42310670 0.243 NM_001207020
SHISA8
shisa homolog 8 (Xenopus laevis)
chr12_+_65218441 0.243 TBC1D30
TBC1 domain family, member 30
chr6_-_42858526 0.241 NM_001008739
C6orf226
chromosome 6 open reading frame 226
chr6_+_33589045 0.241 NM_002224
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr9_+_2621740 0.241 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chr12_+_83080901 0.240 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr13_-_77460369 0.240 KCTD12
potassium channel tetramerisation domain containing 12
chr10_+_99473478 0.239 MARVELD1
MARVEL domain containing 1
chr13_-_113344050 0.237 LOC440149
uncharacterized LOC440149
chr4_+_186317964 0.237 ANKRD37
ankyrin repeat domain 37
chr18_+_3247825 0.236 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr14_+_74003817 0.234 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr18_-_47017940 0.234 NM_001199355
RPL17-C18ORF32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr7_+_152161119 0.234 LOC100128822
uncharacterized LOC100128822
chr5_+_71403040 0.233 NM_005909
MAP1B
microtubule-associated protein 1B
chr10_+_99473456 0.232 NM_031484
MARVELD1
MARVEL domain containing 1
chr19_-_11450254 0.232 NM_004283
RAB3D
RAB3D, member RAS oncogene family
chr3_-_169530306 0.231 LRRC34
leucine rich repeat containing 34
chr12_-_56122800 0.231 CD63
CD63 molecule
chr16_+_27413482 0.230 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr21_+_34697197 0.229 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr1_+_27320132 0.228 NM_001013642
TRNP1
TMF1-regulated nuclear protein 1
chr11_-_86383355 0.227 NM_006680
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr16_-_2770551 0.227 NM_031948
PRSS27
protease, serine 27
chr12_-_21810769 0.227 LDHB
lactate dehydrogenase B
chr2_+_65663812 0.226 FLJ16124
FLJ16124 protein
chr11_+_27062508 0.226 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr4_+_56262051 0.224 NM_018475
TMEM165
transmembrane protein 165
chr8_-_105601124 0.224 LRP12
low density lipoprotein receptor-related protein 12
chr7_-_32982574 0.224 RP9P
retinitis pigmentosa 9 pseudogene
chr18_+_76829410 0.223 ATP9B
ATPase, class II, type 9B
chr7_-_5461517 0.223 TNRC18
trinucleotide repeat containing 18
chr14_+_74058409 0.222 NM_152331
ACOT4
acyl-CoA thioesterase 4
chr14_+_23305913 0.222 MMP14
matrix metallopeptidase 14 (membrane-inserted)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.