Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.499


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)



Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_46293215 0.370 RCAN2
regulator of calcineurin 2
chr3_-_119963141 0.280 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr14_+_62462540 0.237 NM_031914
SYT16
synaptotagmin XVI
chr7_-_27205123 0.208 HOXA9
homeobox A9
chr7_-_27205148 0.208 NM_152739
HOXA9
homeobox A9
chr13_-_46425756 0.188 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr4_+_90033967 0.175 NM_145715
TIGD2
tigger transposable element derived 2
chr10_-_96829074 0.172 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr1_+_50569581 0.166 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_-_39092714 0.163 KRT23
keratin 23 (histone deacetylase inducible)
chr8_-_72268720 0.161 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr5_+_174151531 0.157 NM_002449
MSX2
msh homeobox 2
chr12_-_10324675 0.153 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr13_+_36050885 0.152 NM_001204197
NBEA
neurobeachin
chr6_+_16143281 0.145 MYLIP
myosin regulatory light chain interacting protein
chr6_-_119252887 0.145 NM_017696
MCM9
minichromosome maintenance complex component 9
chr3_-_139195300 0.142 NM_004164
RBP2
retinol binding protein 2, cellular
chr9_-_14086901 0.141 NFIB
nuclear factor I/B
chr1_+_50574589 0.139 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr6_+_100054649 0.138 NM_021620
PRDM13
PR domain containing 13
chr12_-_6484389 0.136 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chrX_+_115567746 0.135 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr22_-_38506532 0.135 BAIAP2L2
BAI1-associated protein 2-like 2
chr3_+_159943252 0.133 NM_001168214
C3orf80
chromosome 3 open reading frame 80
chr12_-_123201319 0.126 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr14_+_21756135 0.118 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr9_-_85882093 0.118 NM_001244962
FRMD3
FERM domain containing 3
chr7_+_139528951 0.117 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_167883243 0.116 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr3_+_156394452 0.116 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr12_-_6484904 0.115 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr17_-_39093671 0.115 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr19_+_16244837 0.108 NM_032855
HSH2D
hematopoietic SH2 domain containing
chr7_+_94297448 0.108 PEG10
paternally expressed 10
chr7_+_116451073 0.106 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr17_+_59489111 0.106 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr5_-_88199868 0.105 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr1_+_50575465 0.104 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr20_-_55934877 0.101 NM_001190472
MTRNR2L3
MT-RNR2-like 3
chr10_+_102123420 0.097


chr13_+_99058147 0.097


chr7_+_129984629 0.096 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr11_+_87032428 0.092 TMEM135
transmembrane protein 135
chr2_+_171571800 0.092 NM_001003845
SP5
Sp5 transcription factor
chr5_+_71502700 0.092 MAP1B
microtubule-associated protein 1B
chr4_+_86749045 0.091 ARHGAP24
Rho GTPase activating protein 24
chr4_+_69681709 0.090 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr1_+_174933904 0.090 NM_001243764
RABGAP1L
RAB GTPase activating protein 1-like
chr10_-_98031154 0.088 NM_001114094
NM_013314
BLNK

B-cell linker

chr19_-_41812991 0.088


chr10_+_126630691 0.088 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr1_-_150738232 0.088 CTSS
cathepsin S
chr3_+_151488214 0.086 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr2_+_29038862 0.085 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr16_-_4852856 0.085


chr4_-_105416050 0.084 CXXC4
CXXC finger protein 4
chr1_+_117297056 0.084 NM_001767
CD2
CD2 molecule
chr12_-_27924208 0.084 NM_001146221
MANSC4
MANSC domain containing 4
chr15_+_40294749 0.083 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr1_-_200377262 0.082 ZNF281
zinc finger protein 281
chr13_+_50589389 0.082 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr7_+_18535817 0.081 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr1_-_200377488 0.081 ZNF281
zinc finger protein 281
chr1_+_84768333 0.081 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr4_-_21699317 0.080 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr6_+_152011630 0.080 NM_001122742
ESR1
estrogen receptor 1
chr4_-_69817478 0.078 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr2_-_99871569 0.077 NM_175735
LYG2
lysozyme G-like 2
chr19_+_48828820 0.074 EMP3
epithelial membrane protein 3
chr9_+_82187469 0.071 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_+_74553845 0.071 LOC100507246
uncharacterized LOC100507246
chr12_-_10588543 0.071 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr10_+_95517565 0.070 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chrX_+_107288199 0.070 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr5_-_147162264 0.069 JAKMIP2
janus kinase and microtubule interacting protein 2
chr4_+_186350543 0.069 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr9_+_82187599 0.068 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr13_-_61989654 0.068 NM_022843
PCDH20
protocadherin 20
chr6_-_123957941 0.068 NM_001251987
NM_006073
TRDN

triadin

chr1_-_23886284 0.068 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr11_-_18258315 0.067 SAA4
serum amyloid A4, constitutive
chr2_+_102508333 0.067 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_102508377 0.066 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr6_-_46293404 0.065 RCAN2
regulator of calcineurin 2
chr1_+_167298382 0.065 POU2F1
POU class 2 homeobox 1
chr12_-_15114495 0.065 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_-_24690740 0.065 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr3_+_25470067 0.065 RARB
retinoic acid receptor, beta
chr2_-_74382352 0.063


chr17_-_1248346 0.063 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr2_+_202671197 0.063 NM_139158
CDK15
cyclin-dependent kinase 15
chr12_-_16757944 0.063 LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_-_147162251 0.063 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr1_+_14031349 0.062 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr5_-_88119604 0.061 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr12_-_58135853 0.060 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr17_-_67138013 0.060 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr5_+_139505519 0.060 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr2_+_210444364 0.059 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chrX_+_22050920 0.059 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr3_-_112218383 0.059 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr5_+_40909558 0.058 NM_000587
C7
complement component 7
chr5_-_22853730 0.058 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr2_-_192016293 0.058 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr4_-_152149042 0.057 NM_001243349
SH3D19
SH3 domain containing 19
chr8_+_104310660 0.057 NM_001164615
FZD6
frizzled family receptor 6
chr15_+_89739234 0.057 ABHD2
abhydrolase domain containing 2
chr7_-_96654128 0.056 NM_005221
DLX5
distal-less homeobox 5
chr2_+_179184970 0.056 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr3_-_100712248 0.056 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr4_+_77953942 0.055 SEPT11
septin 11
chr2_-_142888540 0.054 LRP1B
low density lipoprotein receptor-related protein 1B
chr8_-_101936521 0.054 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_-_71592707 0.054 NM_001244816
FOXP1
forkhead box P1
chr5_-_132200476 0.054 NM_005260
GDF9
growth differentiation factor 9
chr5_-_90610218 0.054 LOC100505994
uncharacterized LOC100505994
chr12_-_10282680 0.054 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_-_173962050 0.054 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr1_-_183560010 0.054 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr10_+_81073763 0.053 ZMIZ1
zinc finger, MIZ-type containing 1
chr1_-_160832466 0.053 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr13_+_96085852 0.053 NM_001160100
NM_182848
CLDN10

claudin 10

chrM_+_5245 0.053


chr1_-_110155672 0.052 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr3_+_8543508 0.052 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr3_+_178254223 0.051 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_+_21679190 0.051 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr3_+_46448678 0.051 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr7_-_41742666 0.051 NM_002192
INHBA
inhibin, beta A
chr19_-_3772208 0.051 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chr11_+_27015668 0.050


chr6_+_131571298 0.050 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr2_+_189839078 0.050 NM_000090
COL3A1
collagen, type III, alpha 1
chr1_+_168250277 0.050 NM_005149
TBX19
T-box 19
chr20_+_5987897 0.050 NM_001127458
CRLS1
cardiolipin synthase 1
chr12_-_16759420 0.050 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_143929316 0.049 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr16_-_46782104 0.049 NM_182493
MYLK3
myosin light chain kinase 3
chr1_-_32385258 0.049 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr1_-_150738255 0.049 CTSS
cathepsin S
chr13_+_50025687 0.048 NM_001160308
SETDB2
SET domain, bifurcated 2
chr2_-_128100673 0.048 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr12_-_10573041 0.048 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr15_-_73051650 0.047


chr9_+_82186846 0.047 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_50571963 0.047 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_-_18258383 0.047 NM_006512
SAA4
serum amyloid A4, constitutive
chr12_-_16759531 0.047 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_69037498 0.046 C3orf64
chromosome 3 open reading frame 64
chr12_-_53901371 0.046 NM_003717
NPFF
neuropeptide FF-amide peptide precursor
chr12_+_32654976 0.046 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr17_+_27370155 0.046 PIPOX
pipecolic acid oxidase
chr20_+_19915716 0.046 RIN2
Ras and Rab interactor 2
chr5_+_61874561 0.045 NM_181506
LRRC70
leucine rich repeat containing 70
chr6_+_155538096 0.045 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr11_+_34642651 0.045 EHF
ets homologous factor
chr5_+_40909617 0.044 C7
complement component 7
chr6_+_135517051 0.044 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_-_117747017 0.044 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr6_-_66417069 0.044 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr11_-_104972147 0.044 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr14_-_65409445 0.043 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_-_56494889 0.043 RNF43
ring finger protein 43
chr12_-_11150473 0.042 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr5_+_140186658 0.042 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr13_+_49050585 0.042 RB1
retinoblastoma 1
chr12_-_91505215 0.042 LUM
lumican
chr2_+_198380294 0.042 NM_199482
MOB4
MOB family member 4, phocein
chr4_+_68424444 0.042 NM_012108
STAP1
signal transducing adaptor family member 1
chr16_-_21663908 0.041 IGSF6
immunoglobulin superfamily, member 6
chrX_+_105937067 0.041 NM_024539
RNF128
ring finger protein 128
chr12_-_16759939 0.041 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_27777713 0.041 NM_003536
HIST1H3H
histone cluster 1, H3h
chr3_-_151158558 0.041 NM_001178145
NM_001178146
IGSF10

immunoglobulin superfamily, member 10

chr21_-_36421630 0.041 RUNX1
runt-related transcription factor 1
chr22_-_41257998 0.041 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr10_-_61900659 0.041 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_23891608 0.040 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_+_183943286 0.040 NM_001142314
NM_080876
DUSP19

dual specificity phosphatase 19

chr1_+_167298280 0.040 NM_001198783
POU2F1
POU class 2 homeobox 1
chr5_+_55149149 0.040 NM_001242636
NM_001242639
IL31RA

interleukin 31 receptor A

chr17_+_57915192 0.039


chr8_-_12973752 0.039 NM_001164271
DLC1
deleted in liver cancer 1
chr5_-_149669400 0.039 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr12_-_22089627 0.039 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr4_+_30721865 0.039 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr1_+_183774214 0.038 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr7_+_141478241 0.038 NM_016944
TAS2R4
taste receptor, type 2, member 4
chrM_+_4770 0.038


chr3_+_121613170 0.038 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr1_+_50574601 0.038 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_-_46285752 0.038 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr3_+_157154579 0.037 NM_002852
PTX3
pentraxin 3, long
chr4_+_146031528 0.037 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr2_+_189839132 0.037 COL3A1
collagen, type III, alpha 1
chr5_+_31193761 0.037 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr2_+_33738941 0.037 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_+_140868721 0.036 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr4_+_160188997 0.036 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr6_+_41020939 0.036 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.