Motif ID: NRF1.p2

Z-value: 4.725


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NRF1hg19_v1_chr7_+_129251579_1292516450.731.0e-01Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_260092 11.175 NM_001013672
C17orf97
chromosome 17 open reading frame 97
chrX_+_7065820 4.962 STS
steroid sulfatase (microsomal), isozyme S
chr5_-_1594617 3.299 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr1_-_110052285 3.260 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr6_+_30614815 3.196 NM_001109938
NM_001161376
NM_145029
C6orf136


chromosome 6 open reading frame 136


chr16_+_27215295 3.143 NM_001145348
JMJD5
jumonji domain containing 5
chr2_-_74734498 3.039 PCGF1
polycomb group ring finger 1
chr19_-_41870001 2.993 NM_030578
B9D2
B9 protein domain 2
chr4_+_668250 2.884 MYL5
myosin, light chain 5, regulatory
chr6_+_26021906 2.537 NM_003538
HIST1H4A
histone cluster 1, H4a
chr6_+_75994713 2.447 LOC100506804
uncharacterized LOC100506804
chr6_+_26217145 2.343 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr18_-_74534205 2.274 LOC100131655
uncharacterized LOC100131655
chr11_+_1331048 2.239 LOC255512
uncharacterized LOC255512
chr11_+_65029312 2.096 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr2_+_101179395 2.079 NM_024065
PDCL3
phosducin-like 3
chr6_+_26199712 2.033 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr9_+_110045516 2.017 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr11_-_777470 1.977 NM_182612
PDDC1
Parkinson disease 7 domain containing 1
chr9_-_139981102 1.962 LOC100289341
uncharacterized LOC100289341
chr17_-_34257730 1.956 NM_001034836
NM_001163120
NM_001163121
NM_145654
RDM1



RAD52 motif 1



chr4_-_7044664 1.939 NM_153376
CCDC96
coiled-coil domain containing 96
chr19_-_44259072 1.916 SMG9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr16_+_28565279 1.863 CCDC101
coiled-coil domain containing 101
chr19_+_18794487 1.769 CRTC1
CREB regulated transcription coactivator 1
chr19_-_14016908 1.738 NM_024323
C19orf57
chromosome 19 open reading frame 57
chr11_-_64545231 1.729 NM_001178031
SF1
splicing factor 1
chr16_+_28565225 1.726 NM_138414
CCDC101
coiled-coil domain containing 101
chr20_-_44563573 1.701 FLJ40606
uncharacterized LOC643549
chr6_-_153304590 1.697 NM_001142522
FBXO5
F-box protein 5
chr9_+_110045822 1.697 RAD23B
RAD23 homolog B (S. cerevisiae)
chr3_+_49449638 1.690 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr20_+_13976263 1.687 MACROD2
MACRO domain containing 2
chr19_-_44258971 1.685 SMG9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr16_-_11350038 1.669 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr3_+_49449753 1.629 TCTA
T-cell leukemia translocation altered gene
chr19_-_44259115 1.611 NM_019108
SMG9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr6_+_27775898 1.609 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr9_+_110045551 1.608 RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_+_91966365 1.577 NM_001134419
NM_003503
CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr9_-_139981268 1.573 LOC100289341
uncharacterized LOC100289341
chr7_+_113726490 1.570 FOXP2
forkhead box P2
chr13_-_49107185 1.542 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr13_-_21348054 1.537 NM_174928
N6AMT2
N-6 adenine-specific DNA methyltransferase 2 (putative)
chr11_+_76092336 1.514 LOC100506127
putative uncharacterized protein FLJ37770-like
chr4_-_184425610 1.498 LOC389247
uncharacterized LOC389247
chr10_-_15139301 1.490 NM_153244
C10orf111
chromosome 10 open reading frame 111
chr19_+_18794391 1.464 NM_001098482
NM_015321
CRTC1

CREB regulated transcription coactivator 1

chr6_-_42981656 1.463 MEA1
male-enhanced antigen 1
chr22_+_24200040 1.459 NM_001024939
SLC2A11
solute carrier family 2 (facilitated glucose transporter), member 11
chr10_-_134145333 1.457 STK32C
serine/threonine kinase 32C
chrX_+_13671224 1.454 NM_152634
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr17_-_26220372 1.451 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr5_-_11903964 1.426 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr6_+_27861202 1.421 NM_003527
HIST1H2BO
histone cluster 1, H2bo
chr3_+_149689065 1.419 LOC646903
uncharacterized LOC646903
chr13_-_49107250 1.419 NM_001268
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr2_+_17721806 1.403 NM_003385
VSNL1
visinin-like 1
chr12_+_2921786 1.392 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr21_-_30257611 1.385 NM_013240
NM_182749
N6AMT1

N-6 adenine-specific DNA methyltransferase 1 (putative)

chr14_-_47120940 1.378 NM_080746
RPL10L
ribosomal protein L10-like
chr1_+_91966653 1.354 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr11_-_45939361 1.352 PEX16
peroxisomal biogenesis factor 16
chr2_+_203776930 1.349 NM_001104586
NM_024744
ALS2CR8

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

chr3_+_51705221 1.345 NM_001129884
NM_001243727
NM_015926
NM_001243725
NM_001243726
TEX264




testis expressed 264




chr2_+_17721983 1.324 VSNL1
visinin-like 1
chr2_-_74734785 1.323 NM_032673
PCGF1
polycomb group ring finger 1
chr14_+_67827060 1.323 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr3_-_126373957 1.318 NM_001173513
NM_052883
TXNRD3

thioredoxin reductase 3

chr8_-_65711104 1.308 NM_004820
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr16_-_3661579 1.307 NM_032444
SLX4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr3_-_59035700 1.307 NM_198463
C3orf67
chromosome 3 open reading frame 67
chr12_+_109535377 1.302 NM_080911
UNG
uracil-DNA glycosylase
chr19_+_36236460 1.296 NM_172341
PSENEN
presenilin enhancer 2 homolog (C. elegans)
chr17_+_40811261 1.295 NM_016437
TUBG2
tubulin, gamma 2
chr16_+_27214806 1.290 NM_024773
JMJD5
jumonji domain containing 5
chr2_-_130939146 1.285 NM_001171083
NM_017751
NM_017951
SMPD4


sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)


chr4_-_668035 1.278 NM_007100
ATP5I
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr1_+_226411318 1.277 NM_031944
MIXL1
Mix paired-like homeobox
chr22_-_31742217 1.272 NM_014323
NM_032050
NM_032051
NM_032052
PATZ1



POZ (BTB) and AT hook containing zinc finger 1



chr22_+_19159198 1.267 LOC100652736
uncharacterized LOC100652736
chr20_-_10654429 1.261 NM_000214
JAG1
jagged 1
chr5_-_11904127 1.255 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr11_+_1330977 1.252 LOC255512
uncharacterized LOC255512
chr6_+_27114860 1.242 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr4_-_146019296 1.234 NM_014885
ANAPC10
anaphase promoting complex subunit 10
chrX_+_21392396 1.232 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr10_-_134145325 1.226 STK32C
serine/threonine kinase 32C
chr9_+_110045565 1.225 RAD23B
RAD23 homolog B (S. cerevisiae)
chr7_+_6746703 1.219


chr9_+_71395079 1.215


chr7_+_100027253 1.211 NM_019606
MEPCE
methylphosphate capping enzyme
chr17_+_7387773 1.210 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr7_+_100027404 1.206 MEPCE
methylphosphate capping enzyme
chr7_-_142985270 1.204


chr12_-_54069856 1.189 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr7_+_149571029 1.181 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr9_-_34522972 1.179 NM_198573
ENHO
energy homeostasis associated
chr13_-_49107218 1.176 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr17_+_7387688 1.173 NM_000937
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr17_-_3571819 1.170 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr1_+_167189948 1.169 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr7_+_154795131 1.168 LOC202781
uncharacterized LOC202781
chr16_+_3019466 1.168 PAQR4
progestin and adipoQ receptor family member IV
chr11_+_65101345 1.168 DPF2
D4, zinc and double PHD fingers family 2
chr17_+_7487125 1.167 MPDU1
mannose-P-dolichol utilization defect 1
chr6_+_111408648 1.159 SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr6_-_27775683 1.156 NM_003519
HIST1H2BL
histone cluster 1, H2bl
chr12_+_31226824 1.148 DDX11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
chr17_+_4843585 1.142 NM_015528
RNF167
ring finger protein 167
chr10_-_124639077 1.138 NM_001204364
NM_152644
FAM24B-CUZD1
FAM24B

FAM24B-CUZD1 readthrough
family with sequence similarity 24, member B

chr9_-_140513222 1.127 NM_032937
C9orf37
chromosome 9 open reading frame 37
chr6_+_31126340 1.126 TCF19
transcription factor 19
chr18_-_5296013 1.121 NM_001143823
NM_003409
ZFP161

zinc finger protein 161 homolog (mouse)

chr6_+_31126114 1.119 NM_001077511
NM_007109
TCF19

transcription factor 19

chr22_+_45559858 1.104 NUP50
nucleoporin 50kDa
chr19_+_56165415 1.099 NM_001012478
NM_007279
U2AF2

U2 small nuclear RNA auxiliary factor 2

chr22_-_31741761 1.099 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr10_+_102820914 1.093 NM_030929
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr7_+_73588602 1.086 EIF4H
eukaryotic translation initiation factor 4H
chr11_+_65101224 1.082 NM_006268
DPF2
D4, zinc and double PHD fingers family 2
chr5_-_472916 1.078 PP7080
uncharacterized LOC25845
chr12_+_57916607 1.074 NM_052897
MBD6
methyl-CpG binding domain protein 6
chr7_+_72300044 1.067 SBDSP1
Shwachman-Bodian-Diamond syndrome pseudogene 1
chr16_+_89753068 1.066 NM_001098533
NM_001160367
NM_052987
NM_052988
CDK10



cyclin-dependent kinase 10



chr6_-_31774579 1.062 LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr12_-_54070108 1.061 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr19_-_36236291 1.060 NM_001040425
NM_144987
U2AF1L4

U2 small nuclear RNA auxiliary factor 1-like 4

chr13_-_20357081 1.059 PSPC1
paraspeckle component 1
chr18_-_12884140 1.052 NM_001207013
NM_002828
NM_080422
NM_080423
PTPN2



protein tyrosine phosphatase, non-receptor type 2



chr6_-_31774725 1.045 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr9_+_115142395 1.042 HSDL2
hydroxysteroid dehydrogenase like 2
chr11_-_106888829 1.042 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr9_+_115142188 1.037 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr12_-_53574379 1.036 NM_015989
CSAD
cysteine sulfinic acid decarboxylase
chr22_-_31741565 1.027 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chrX_-_30907408 1.025 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr2_-_106810781 1.023 NM_025076
UXS1
UDP-glucuronate decarboxylase 1
chr22_-_31742329 1.021 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr17_-_4843204 1.018 NM_001165417
NM_001165418
NM_003562
SLC25A11


solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11


chr9_+_134378324 1.011 POMT1
protein-O-mannosyltransferase 1
chr13_-_20356788 1.005 PSPC1
paraspeckle component 1
chr11_-_59436488 1.002 NM_152716
PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr19_-_58874078 0.997 NM_001207009
NM_198458
ZNF497

zinc finger protein 497

chr12_-_48551269 0.986 NM_024095
ASB8
ankyrin repeat and SOCS box containing 8
chr9_+_134378353 0.986 POMT1
protein-O-mannosyltransferase 1
chr19_-_55769920 0.985 NM_014931
PPP6R1
protein phosphatase 6, regulatory subunit 1
chr4_+_47033294 0.984 NM_000812
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr19_+_59055866 0.980 TRIM28
tripartite motif containing 28
chr5_+_137774632 0.979 NM_016606
REEP2
receptor accessory protein 2
chr19_+_59056017 0.976 TRIM28
tripartite motif containing 28
chr7_+_44836309 0.973 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr1_-_202858225 0.972 NM_002871
RABIF
RAB interacting factor
chr15_+_96873845 0.971 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr20_-_10654139 0.967 JAG1
jagged 1
chr14_-_102771469 0.966 NM_014226
MOK
MOK protein kinase
chr4_-_103422436 0.961


chr13_-_50656088 0.961 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr3_+_150321065 0.958 NM_016275
SELT
selenoprotein T
chr17_+_7487153 0.957 MPDU1
mannose-P-dolichol utilization defect 1
chr3_+_122513870 0.954 NM_032839
DIRC2
disrupted in renal carcinoma 2
chr3_-_113233661 0.952 SPICE1
spindle and centriole associated protein 1
chr9_-_140024159 0.951


chr19_+_5690270 0.950 NM_033643
RPL36
ribosomal protein L36
chr18_+_74534458 0.949 ZNF236
zinc finger protein 236
chr16_+_3019341 0.947 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr7_+_142985462 0.942 CASP2
caspase 2, apoptosis-related cysteine peptidase
chr6_+_111408780 0.939 NM_018593
SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter)
chr14_+_75536298 0.938 NM_001042430
NM_024643
FAM164C

family with sequence similarity 164, member C

chr17_-_15902907 0.931 NM_001042697
NM_001042698
ZSWIM7

zinc finger, SWIM-type containing 7

chr1_+_24104906 0.926 PITHD1
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
chr17_+_18128868 0.925 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr19_+_1269244 0.922 NM_001280
CIRBP
cold inducible RNA binding protein
chr21_-_47878592 0.907


chr19_+_50432399 0.901 NM_001193646
ATF5
activating transcription factor 5
chr9_-_111696173 0.898 IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr2_-_106810756 0.896 UXS1
UDP-glucuronate decarboxylase 1
chr8_-_95907423 0.890 NM_057749
CCNE2
cyclin E2
chr17_-_34257285 0.890 NM_001163122
NM_001163124
NM_001163125
NM_001163130
RDM1



RAD52 motif 1



chr17_-_27278324 0.889 PHF12
PHD finger protein 12
chr3_+_126261178 0.885 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr7_+_107384573 0.884 CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr19_-_2236648 0.878 PLEKHJ1
pleckstrin homology domain containing, family J member 1
chr1_-_1535446 0.877 NM_001242659
LOC643988
uncharacterized LOC643988
chr19_-_44079707 0.877 NM_006297
XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr7_-_75115536 0.876 NM_001099415
POM121C
POM121 membrane glycoprotein C
chr14_+_101193313 0.869 DLK1
delta-like 1 homolog (Drosophila)
chr22_+_46646260 0.862 LOC284926
uncharacterized LOC284926
chr19_+_59055826 0.860 NM_005762
TRIM28
tripartite motif containing 28
chr2_-_202483896 0.854 NM_001168216
NM_001168217
NM_001168221
NM_152525
ALS2CR11



amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11



chr19_-_10305600 0.853 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr19_-_55770340 0.853 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr1_+_211556141 0.853 LINC00467
long intergenic non-protein coding RNA 467
chr17_+_7388080 0.852


chr19_+_4910339 0.851 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr19_+_54041332 0.847 NM_001079906
NM_001253798
NM_001253799
ZNF331


zinc finger protein 331


chrX_+_17755562 0.844 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr1_+_211556158 0.843 LINC00467
long intergenic non-protein coding RNA 467
chr4_-_120987890 0.841 NM_002358
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr6_-_170151627 0.840 NM_174910
TCTE3
t-complex-associated-testis-expressed 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
16.15 1.51e-05 GO:0006334 nucleosome assembly
15.32 2.29e-05 GO:0031497 chromatin assembly
14.57 3.40e-05 GO:0034728 nucleosome organization
14.02 4.60e-05 GO:0065004 protein-DNA complex assembly
13.27 7.06e-05 GO:0071824 protein-DNA complex subunit organization
11.70 1.87e-04 GO:0006323 DNA packaging
11.01 2.98e-04 GO:0006333 chromatin assembly or disassembly
10.04 5.98e-04 GO:0071103 DNA conformation change
6.07 8.65e-04 GO:0034622 cellular macromolecular complex assembly
4.33 3.91e-03 GO:0051276 chromosome organization
5.85 1.06e-02 GO:0051325 interphase
4.56 1.30e-02 GO:0034621 cellular macromolecular complex subunit organization
4.34 4.65e-02 GO:0006325 chromatin organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
24.75 9.80e-08 GO:0000786 nucleosome
17.59 1.90e-07 GO:0032993 protein-DNA complex
8.08 4.08e-05 GO:0000785 chromatin
2.88 2.16e-03 GO:0005654 nucleoplasm
4.66 2.17e-03 GO:0044427 chromosomal part
4.26 2.19e-03 GO:0005694 chromosome
1.63 9.16e-03 GO:0044446 intracellular organelle part
1.63 1.06e-02 GO:0005634 nucleus
1.61 1.34e-02 GO:0044422 organelle part
26.52 1.78e-02 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
2.31 1.92e-02 GO:0031981 nuclear lumen

Nothing significant found in function category.