Motif ID: PITX1..3.p2

Z-value: 1.114


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX2hg19_v1_chr4_-_111543907_111543914-0.631.8e-01Click!
PITX1hg19_v1_chr5_-_134369841_1343699780.621.9e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_134212343 2.829 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr12_-_122296619 1.786 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_-_213020947 1.656 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr1_-_42965948 1.562 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr3_-_9921933 1.356 NM_001199551
NM_001199552
CIDEC

cell death-inducing DFFA-like effector c

chr15_+_85359910 1.285 NM_020778
ALPK3
alpha-kinase 3
chr3_-_9920633 1.208 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr22_-_24096551 1.172 NM_013378
VPREB3
pre-B lymphocyte 3
chr21_+_35736322 1.083 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr15_+_29077439 1.033


chr3_-_9920471 0.795 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr5_-_90610218 0.733 LOC100505994
uncharacterized LOC100505994
chr16_-_90096308 0.730 NM_001214
C16orf3
chromosome 16 open reading frame 3
chr15_-_23115243 0.696 LOC283683
uncharacterized LOC283683
chr3_-_109035239 0.676 NM_138815
DPPA2
developmental pluripotency associated 2
chr12_+_52281743 0.667 NM_001130015
NM_182608
ANKRD33

ankyrin repeat domain 33

chr15_-_41522860 0.666 NM_152596
EXD1
exonuclease 3'-5' domain containing 1
chr7_-_143956720 0.655 NM_001005328
OR2A7
olfactory receptor, family 2, subfamily A, member 7
chr2_+_169643048 0.652 NM_001171631
NOSTRIN
nitric oxide synthase trafficker
chr17_-_74483806 0.650 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr19_-_3600576 0.649 TBXA2R
thromboxane A2 receptor
chr19_+_48774653 0.642 NM_153608
ZNF114
zinc finger protein 114
chr16_-_2770551 0.602 NM_031948
PRSS27
protease, serine 27
chr6_+_26501448 0.593 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr17_+_41158741 0.591 NM_005533
IFI35
interferon-induced protein 35
chr7_+_141695678 0.577 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chrX_+_7810302 0.576 NM_013452
VCX
variable charge, X-linked
chr14_+_68168602 0.569 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr11_+_308106 0.558 NM_006435
IFITM2
interferon induced transmembrane protein 2 (1-8D)
chr1_-_183560010 0.557 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr1_+_16330730 0.556 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr6_+_26020677 0.554 NM_003529
HIST1H3A
histone cluster 1, H3a
chr6_-_111927082 0.538 TRAF3IP2
TRAF3 interacting protein 2
chr9_-_99064385 0.525 NM_000197
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr19_+_2389768 0.521 NM_182973
TMPRSS9
transmembrane protease, serine 9
chr1_+_28655512 0.520 NM_001127350
NM_017638
MED18

mediator complex subunit 18

chr15_-_90222572 0.516 NM_001145311
NM_002666
PLIN1

perilipin 1

chr7_+_141490016 0.513 NM_018980
TAS2R5
taste receptor, type 2, member 5
chr19_+_48964505 0.507 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chrX_-_23761396 0.470 NM_001033583
NM_001037171
ACOT9

acyl-CoA thioesterase 9

chr11_+_111789600 0.456 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr16_+_30210548 0.454 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr2_-_211090146 0.453 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr17_+_48351787 0.446 NM_153229
TMEM92
transmembrane protein 92
chr3_-_46249787 0.440 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr12_+_26348268 0.437 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr12_-_123594974 0.437 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr2_-_230933618 0.433 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr17_+_40703983 0.427 NM_000413
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
chr8_+_87111132 0.424 NM_152565
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr19_+_17579577 0.423 SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr16_-_30394133 0.420 NM_052838
SEPT1
septin 1
chr19_-_48614013 0.419 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr14_-_23285011 0.414 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr11_+_35198199 0.414 CD44
CD44 molecule (Indian blood group)
chr11_-_118213321 0.410 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr20_+_361272 0.409 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr19_+_47813074 0.407 NM_001736
C5AR1
complement component 5a receptor 1
chr1_+_112016588 0.402 NM_174896
C1orf162
chromosome 1 open reading frame 162
chr1_-_151826042 0.400 NM_182578
THEM5
thioesterase superfamily member 5
chr16_-_15149827 0.383 NM_173474
NTAN1
N-terminal asparagine amidase
chr16_-_28607694 0.380 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr4_-_74864296 0.379 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr19_-_36643770 0.376 NM_001864
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr14_+_35514112 0.372 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr12_+_7023490 0.372 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr5_+_147582338 0.368 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr18_+_3453771 0.367 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr12_-_50595303 0.367 NM_001243775
LIMA1
LIM domain and actin binding 1
chr7_-_100061893 0.360 NM_001004323
C7orf61
chromosome 7 open reading frame 61
chr19_+_48828627 0.360 NM_001425
EMP3
epithelial membrane protein 3
chr2_-_224866616 0.359 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr8_-_23082653 0.355 NM_003844
TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr12_-_21810754 0.351 LDHB
lactate dehydrogenase B
chr1_-_150738292 0.351 NM_001199739
NM_004079
CTSS

cathepsin S

chr16_-_28550227 0.348 NUPR1
nuclear protein, transcriptional regulator, 1
chr12_-_13103317 0.348 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr3_+_195447751 0.347 NM_152673
MUC20
mucin 20, cell surface associated
chr8_-_23082572 0.346 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr14_-_75530716 0.341 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr18_+_55297533 0.340 NM_001242804
LOC100505549
uncharacterized LOC100505549
chr11_+_111789658 0.336 C11orf52
chromosome 11 open reading frame 52
chr12_-_10826890 0.335 NM_018423
STYK1
serine/threonine/tyrosine kinase 1
chr7_+_100770378 0.334 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr19_-_39402797 0.328 NM_001243212
LOC643669
uncharacterized LOC643669
chr16_-_3422282 0.328 NM_001190476
MTRNR2L4
MT-RNR2-like 4
chr15_+_71433787 0.327 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr16_-_74734687 0.326 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr14_-_74025643 0.324 NM_001220484
NM_203309
HEATR4

HEAT repeat containing 4

chr20_+_36011936 0.322 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr17_-_39684585 0.322 NM_002276
KRT19
keratin 19
chr17_-_41174431 0.320 NM_006373
VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr11_-_64764388 0.320 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr1_-_160832466 0.319 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr10_-_92681025 0.316 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_40517913 0.313 NM_019027
RBM47
RNA binding motif protein 47
chr22_+_39417117 0.311 NM_152426
APOBEC3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr4_-_140201339 0.311 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr19_-_55836668 0.310 NM_001085488
TMEM150B
transmembrane protein 150B
chr16_-_21854755 0.310 LOC100132247
NPIPL3
LOC613037
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
nuclear pore complex interacting protein pseudogene
chr7_+_23530136 0.309 RPS2P32
ribosomal protein S2 pseudogene 32
chr19_-_16250695 0.305


chr14_-_50862616 0.303 NM_004196
CDKL1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr3_+_169755733 0.301 NM_014373
GPR160
G protein-coupled receptor 160
chr22_-_41636855 0.301 NM_138481
CHADL
chondroadherin-like
chr19_-_8642309 0.300 NM_012335
MYO1F
myosin IF
chr7_+_48128225 0.300 NM_181597
UPP1
uridine phosphorylase 1
chr2_-_130902568 0.298 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr4_-_88243994 0.296 NM_001136230
NM_178135
HSD17B13

hydroxysteroid (17-beta) dehydrogenase 13

chr5_-_133702764 0.295 NM_001113575
NM_016508
CDKL3

cyclin-dependent kinase-like 3

chr17_+_48348766 0.289 NM_001168215
TMEM92
transmembrane protein 92
chr19_-_15343194 0.288 NM_024794
EPHX3
epoxide hydrolase 3
chr17_-_79838899 0.288


chr16_-_1922079 0.286 NM_152764
C16orf73
chromosome 16 open reading frame 73
chr7_+_37960162 0.285 NM_001242946
NM_017549
EPDR1

ependymin related protein 1 (zebrafish)

chr10_-_70287249 0.282 NM_152707
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr6_-_10694837 0.280 NM_001145020
C6orf52
chromosome 6 open reading frame 52
chr19_-_15311773 0.279 NM_000435
NOTCH3
notch 3
chr19_-_12792676 0.278 DHPS
deoxyhypusine synthase
chr19_-_46142662 0.278 NM_012155
EML2
echinoderm microtubule associated protein like 2
chr1_+_212788359 0.275 NM_001206486
ATF3
activating transcription factor 3
chr6_+_49518112 0.272 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr19_+_12203077 0.269 ZNF788
zinc finger family member 788
chr1_+_26503973 0.268 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr16_+_16146611 0.268


chr4_+_41983712 0.267 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr16_+_89984286 0.266 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chrX_-_15620191 0.264 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr19_-_12792577 0.264 DHPS
deoxyhypusine synthase
chr12_-_6756533 0.263 NM_032489
ACRBP
acrosin binding protein
chr1_-_51796230 0.263 TTC39A
tetratricopeptide repeat domain 39A
chr14_+_74058409 0.261 NM_152331
ACOT4
acyl-CoA thioesterase 4
chr12_+_16506350 0.260 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr6_-_111927059 0.259 TRAF3IP2
TRAF3 interacting protein 2
chr3_-_124842442 0.258 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr6_-_44233499 0.258 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr12_+_26348488 0.257 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_+_26504024 0.255 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr7_+_75831194 0.253 NM_001110199
SRRM3
serine/arginine repetitive matrix 3
chr1_+_12403045 0.250 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr9_-_41954687 0.249 MGC21881
uncharacterized locus MGC21881
chr19_-_47735858 0.247 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr7_+_44078677 0.246 FLJ35390
uncharacterized LOC255031
chr6_-_31648140 0.246 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr4_-_23891608 0.246 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr19_-_3480514 0.244 NM_001136503
C19orf77
chromosome 19 open reading frame 77
chr1_+_218518675 0.243 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr10_+_48255223 0.243 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr12_-_21810733 0.243 LDHB
lactate dehydrogenase B
chr1_-_161279724 0.243 NM_000530
MPZ
myelin protein zero
chr16_-_1922161 0.242 NM_001163560
C16orf73
chromosome 16 open reading frame 73
chr16_+_4845265 0.238 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr8_-_124253584 0.237 NM_032847
C8orf76
chromosome 8 open reading frame 76
chr17_+_4802866 0.236 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr12_+_65224214 0.233


chr7_+_17382900 0.233 AHR
aryl hydrocarbon receptor
chr12_-_21810779 0.230 NM_002300
LDHB
lactate dehydrogenase B
chr11_-_47736896 0.229 NM_024783
AGBL2
ATP/GTP binding protein-like 2
chr19_-_5870546 0.228 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chrX_+_49028183 0.228 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chrX_-_23761264 0.228 ACOT9
acyl-CoA thioesterase 9
chr19_+_48216600 0.227 NM_014601
EHD2
EH-domain containing 2
chr17_-_67311773 0.227 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr11_-_62607627 0.225 NM_018093
WDR74
WD repeat domain 74
chr20_+_361675 0.223 TRIB3
tribbles homolog 3 (Drosophila)
chr1_-_32707198 0.223 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr9_-_90589593 0.223 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr10_+_96443250 0.223 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr9_+_75766777 0.222 NM_000700
ANXA1
annexin A1
chr14_+_77787229 0.222 NM_145870
NM_145871
GSTZ1

glutathione transferase zeta 1

chr19_-_46142643 0.221 EML2
echinoderm microtubule associated protein like 2
chr12_-_105478218 0.221 NM_001034173
ALDH1L2
aldehyde dehydrogenase 1 family, member L2
chr19_+_3585541 0.220 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr1_+_168545710 0.220 NM_002995
XCL1
chemokine (C motif) ligand 1
chr20_+_62492565 0.219 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr1_-_168513201 0.219 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr11_-_118436591 0.218 NM_001168618
NM_020153
IFT46

intraflagellar transport 46 homolog (Chlamydomonas)

chr6_-_32160637 0.218 GPSM3
G-protein signaling modulator 3
chr4_-_186300151 0.217 NM_018409
LRP2BP
LRP2 binding protein
chr7_+_1570321 0.215 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr12_-_21810769 0.214 LDHB
lactate dehydrogenase B
chr19_-_38183135 0.213 NM_152605
ZNF781
zinc finger protein 781
chr3_-_57199402 0.213 NM_017563
IL17RD
interleukin 17 receptor D
chr7_-_144533118 0.209 NM_001042482
NM_022445
TPK1

thiamin pyrophosphokinase 1

chr17_-_62097937 0.208 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr3_+_9691198 0.205 MTMR14
myotubularin related protein 14
chr3_+_42632341 0.204 SS18L2
synovial sarcoma translocation gene on chromosome 18-like 2
chrX_-_23761389 0.204 ACOT9
acyl-CoA thioesterase 9
chr19_+_6135650 0.202 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr1_+_995109 0.201 LOC100288175
uncharacterized LOC100288175
chr22_-_36635999 0.201 NM_145637
APOL2
apolipoprotein L, 2
chr12_+_123942650 0.200 NM_022717
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr20_+_61476475 0.200 NM_080750
DPH3P1
DPH3, KTI11 homolog (S. cerevisiae) pseudogene 1
chr22_-_31686707 0.199 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr1_+_161228516 0.199 NM_001102566
PCP4L1
Purkinje cell protein 4 like 1
chr17_-_7493389 0.199 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr19_-_40732563 0.198 NM_024877
CNTD2
cyclin N-terminal domain containing 2
chr11_-_124543598 0.198 NM_170601
SIAE
sialic acid acetylesterase
chr1_-_151966713 0.197 NM_002966
S100A10
S100 calcium binding protein A10
chr11_+_10482677 0.196 NM_001172430
AMPD3
adenosine monophosphate deaminase 3

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.