Motif ID: SMAD1..7,9.p2

Z-value: 0.761


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v1_chr15_+_67418053_67418193-0.872.6e-02Click!
SMAD5hg19_v1_chr5_+_135468538_135468630-0.414.2e-01Click!
SMAD7hg19_v1_chr18_-_46475702_46475702-0.374.7e-01Click!
SMAD6hg19_v1_chr15_+_66995414_669957050.345.1e-01Click!
SMAD4hg19_v1_chr18_+_48556483_48556586-0.335.3e-01Click!
SMAD1hg19_v1_chr4_+_146403955_146403962-0.315.5e-01Click!
SMAD2hg19_v1_chr18_-_45456925_45456925-0.236.7e-01Click!
SMAD9hg19_v1_chr13_-_37494370_37494408-0.069.1e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_66103874 0.697 NM_004292
RIN1
Ras and Rab interactor 1
chr19_+_35773409 0.620 NM_021175
HAMP
hepcidin antimicrobial peptide
chr11_-_116693907 0.549 NM_000482
APOA4
apolipoprotein A-IV
chr11_-_320775 0.436 NM_021034
IFITM3
interferon induced transmembrane protein 3
chr19_+_2249112 0.348 NM_000479
AMH
anti-Mullerian hormone
chr19_-_41934634 0.343 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr3_+_9944511 0.328 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr1_-_27998719 0.315 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chrX_+_100474932 0.310 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr11_-_320925 0.302 IFITM3
interferon induced transmembrane protein 3
chr15_+_42131010 0.300 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr2_+_37571752 0.291 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr5_-_151066492 0.289 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_+_32666201 0.284 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr21_-_45960071 0.276 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr5_-_151066445 0.273 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr22_+_31518923 0.258 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr1_+_206808751 0.257 NM_001004023
NM_003582
DYRK3

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

chr1_-_204329043 0.244 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chrX_-_48328601 0.241 NM_033518
SLC38A5
solute carrier family 38, member 5
chr16_-_11350038 0.239 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr8_+_144451014 0.236 NM_052924
RHPN1
rhophilin, Rho GTPase binding protein 1
chr20_-_43024303 0.222


chr3_+_9944295 0.217 NM_153483
IL17RE
interleukin 17 receptor E
chr2_+_71162995 0.217 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr16_-_22012427 0.216 NM_173806
PDZD9
PDZ domain containing 9
chr11_+_117075682 0.211 TAGLN
transgelin
chr19_+_3708358 0.206 TJP3
tight junction protein 3 (zona occludens 3)
chr19_-_54676813 0.204 NM_001145303
NM_144686
TMC4

transmembrane channel-like 4

chr22_-_39052306 0.198 LOC646851
putative uncharacterized protein LOC388900
chr19_+_1040114 0.198 ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr4_-_8160435 0.197 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr1_+_180199432 0.197 NM_033343
LHX4
LIM homeobox 4
chr9_+_136501484 0.196 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr17_-_19619878 0.193 NM_001099646
NM_152908
SLC47A2

solute carrier family 47, member 2

chr22_-_24640850 0.191 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr4_-_5828587 0.188 CRMP1
collapsin response mediator protein 1
chr14_+_105941061 0.187 NM_001312
CRIP2
cysteine-rich protein 2
chr3_+_147127826 0.187 ZIC1
Zic family member 1
chr3_-_52479042 0.184 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr16_+_82068910 0.183 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr19_-_36303766 0.182 PRODH2
proline dehydrogenase (oxidase) 2
chr1_+_16062808 0.180 NM_207348
SLC25A34
solute carrier family 25, member 34
chr1_-_27998658 0.179 IFI6
interferon, alpha-inducible protein 6
chr17_-_62914902 0.177 NM_199340
LRRC37A3
leucine rich repeat containing 37, member A3
chr16_+_82068958 0.176 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr1_+_156211950 0.173 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr19_-_49116693 0.173 NM_017708
FAM83E
family with sequence similarity 83, member E
chr21_-_47878592 0.170


chr2_+_203776930 0.169 NM_001104586
NM_024744
ALS2CR8

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

chrX_-_48328564 0.169 SLC38A5
solute carrier family 38, member 5
chr17_-_62915580 0.168 LRRC37A3
leucine rich repeat containing 37, member A3
chr4_+_15779887 0.166 NM_001775
CD38
CD38 molecule
chr10_-_90342947 0.165 NM_001031709
NM_018363
RNLS

renalase, FAD-dependent amine oxidase

chr19_+_11466061 0.161 NM_001170635
NM_022737
LPPR2

lipid phosphate phosphatase-related protein type 2

chr19_+_11466173 0.160 LPPR2
lipid phosphate phosphatase-related protein type 2
chr2_+_17721806 0.158 NM_003385
VSNL1
visinin-like 1
chr2_+_18059923 0.158 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr5_-_149535309 0.157 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr5_+_31193852 0.157 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr8_+_22409423 0.154 SORBS3
sorbin and SH3 domain containing 3
chr17_+_46019022 0.154 PNPO
pyridoxamine 5'-phosphate oxidase
chr2_-_219925237 0.153 NM_002181
IHH
Indian hedgehog
chr19_+_7911385 0.151 NM_001159944
EVI5L
ecotropic viral integration site 5-like
chr6_+_106959729 0.151 NM_001624
AIM1
absent in melanoma 1
chr11_+_62475113 0.149 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr11_-_60623422 0.148 NM_004778
PTGDR2
prostaglandin D2 receptor 2
chr9_+_126118447 0.148 NM_173689
CRB2
crumbs homolog 2 (Drosophila)
chr11_-_2182408 0.148 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough
chr5_+_42423811 0.147 NM_000163
GHR
growth hormone receptor
chr1_-_204165542 0.146 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr5_-_156390206 0.146 NM_001146726
NM_138379
TIMD4

T-cell immunoglobulin and mucin domain containing 4

chr7_-_1199822 0.146 NM_182491
ZFAND2A
zinc finger, AN1-type domain 2A
chr22_+_31003069 0.145 NM_000355
NM_001184726
TCN2

transcobalamin II

chr2_-_25474948 0.144 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_110009099 0.142 NM_001040709
SYPL2
synaptophysin-like 2
chr1_-_6445737 0.139 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr13_+_32605436 0.139 NM_023037
FRY
furry homolog (Drosophila)
chr5_-_149535420 0.138 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr9_-_140335790 0.138 NM_001033113
NM_198585
ENTPD8

ectonucleoside triphosphate diphosphohydrolase 8

chr19_-_33360641 0.137 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr21_-_36421195 0.137 RUNX1
runt-related transcription factor 1
chr3_+_12525969 0.137 NM_001145392
NM_001145395
NM_025265
TSEN2


tRNA splicing endonuclease 2 homolog (S. cerevisiae)


chr8_-_145578502 0.136 NM_001252402
NM_001252404
C8ORFK29

uncharacterized LOC340393

chr1_+_66458389 0.135 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_-_76975932 0.134 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr2_+_17721983 0.134 VSNL1
visinin-like 1
chr2_-_109605668 0.133 NM_022336
EDAR
ectodysplasin A receptor
chr7_-_1199813 0.132 ZFAND2A
zinc finger, AN1-type domain 2A
chr7_-_1199785 0.132 ZFAND2A
zinc finger, AN1-type domain 2A
chr19_-_35992798 0.131 NM_001035516
DMKN
dermokine
chr16_+_88772884 0.131 NM_001012759
NM_001012762
CTU2

cytosolic thiouridylase subunit 2 homolog (S. pombe)

chr16_+_82068830 0.131 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_-_8063946 0.131 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr3_-_33260706 0.129 NM_015551
SUSD5
sushi domain containing 5
chr20_+_10199455 0.129 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr1_+_201857789 0.129 NM_198149
SHISA4
shisa homolog 4 (Xenopus laevis)
chr1_+_206809048 0.128 DYRK3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr1_+_101003692 0.127 NM_022049
GPR88
G protein-coupled receptor 88
chr2_+_177053306 0.126 NM_024501
HOXD1
homeobox D1
chr7_-_18067445 0.125 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr1_-_27998700 0.124 IFI6
interferon, alpha-inducible protein 6
chr5_+_31193761 0.123 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr9_+_136287119 0.123 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr17_-_7307413 0.123 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 readthrough
chromosome 17 open reading frame 61
chr6_+_35265594 0.123 NM_022047
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr5_-_36301999 0.122 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr3_+_12525930 0.121 NM_001145393
NM_001145394
TSEN2

tRNA splicing endonuclease 2 homolog (S. cerevisiae)

chr3_-_50360109 0.121 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr10_-_126432784 0.120 FAM53B
family with sequence similarity 53, member B
chr2_+_171673380 0.119 GAD1
glutamate decarboxylase 1 (brain, 67kDa)
chr17_+_46018888 0.117 NM_018129
PNPO
pyridoxamine 5'-phosphate oxidase
chr14_-_105261850 0.116 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr2_-_102003923 0.116 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr1_-_220101781 0.116


chr1_-_43919547 0.115 NM_001190880
NM_001243526
NM_031207
HYI


hydroxypyruvate isomerase (putative)


chr19_+_36359346 0.115 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr22_+_30752612 0.115 NM_001017437
CCDC157
coiled-coil domain containing 157
chr6_+_106960326 0.114 AIM1
absent in melanoma 1
chr11_-_64901943 0.114 SYVN1
synovial apoptosis inhibitor 1, synoviolin
chr5_+_176560023 0.112 NSD1
nuclear receptor binding SET domain protein 1
chr2_-_96657538 0.111 ANKRD36C
ankyrin repeat domain 36C
chr7_+_101928417 0.111 SH2B2
SH2B adaptor protein 2
chr10_-_100174891 0.111 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr4_-_1685717 0.111 NM_001013622
NM_001174070
FAM53A

family with sequence similarity 53, member A

chr14_+_95047730 0.110 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr16_+_617010 0.110 NM_176677
NHLRC4
PIGQ
NHL repeat containing 4
phosphatidylinositol glycan anchor biosynthesis, class Q
chr19_-_58067724 0.109 NM_001039654
ZNF550
zinc finger protein 550
chr9_-_98638243 0.109 LINC00476
long intergenic non-protein coding RNA 476
chr1_+_27023932 0.108 ARID1A
AT rich interactive domain 1A (SWI-like)
chr22_-_24110054 0.108 NM_213720
CHCHD10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr1_+_38259458 0.108 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr12_+_113860146 0.107 NM_138432
SDSL
serine dehydratase-like
chr14_+_100203998 0.107 EML1
echinoderm microtubule associated protein like 1
chr10_-_44880452 0.106 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr17_-_70116928 0.106 FLJ37644
uncharacterized LOC400618
chr1_-_204463512 0.105 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr13_+_58205943 0.105 PCDH17
protocadherin 17
chrX_+_21392396 0.103 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr5_+_170847059 0.103 FGF18
fibroblast growth factor 18
chr22_-_31536339 0.103 NM_015715
PLA2G3
phospholipase A2, group III
chr15_-_75017710 0.102 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr4_-_289943 0.102 NM_001137608
ZNF732
zinc finger protein 732
chr6_+_79577188 0.101 NM_001010844
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr18_+_21269528 0.101 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr11_-_568419 0.100 MIR210HG
MIR210 host gene (non-protein coding)
chr15_-_79103571 0.100 NM_014272
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr1_-_32827843 0.099 NM_001167676
LOC100128071
uncharacterized LOC100128071
chr9_-_129884885 0.098 ANGPTL2
angiopoietin-like 2
chr1_+_201857997 0.098 SHISA4
shisa homolog 4 (Xenopus laevis)
chr21_+_44394691 0.098 PKNOX1
PBX/knotted 1 homeobox 1
chr20_-_39317875 0.098 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr7_+_101928390 0.097 NM_020979
SH2B2
SH2B adaptor protein 2
chr20_-_50179167 0.096 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr11_+_10829561 0.096 LOC144017
uncharacterized LOC144017
chr11_-_64901995 0.096 NM_032431
NM_172230
SYVN1

synovial apoptosis inhibitor 1, synoviolin

chr2_+_27309610 0.096 NM_000221
NM_006488
KHK

ketohexokinase (fructokinase)

chr15_+_34638065 0.096 NM_175741
C15orf55
chromosome 15 open reading frame 55
chr11_-_795005 0.095 SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr11_-_63258410 0.095 NM_001146728
NM_001146729
NM_054108
HRASLS5


HRAS-like suppressor family, member 5


chr10_-_44144151 0.095 NM_001005368
ZNF32
zinc finger protein 32
chr10_+_88718287 0.095 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr1_+_36396673 0.094 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr11_-_118927833 0.094 HYOU1
hypoxia up-regulated 1
chr1_-_2564428 0.094 NM_033467
MMEL1
membrane metallo-endopeptidase-like 1
chr2_-_237076613 0.093 NM_001485
GBX2
gastrulation brain homeobox 2
chr1_+_32538497 0.092 NM_018056
TMEM39B
transmembrane protein 39B
chr12_+_90102639 0.092 LOC338758
uncharacterized LOC338758
chr5_-_83680590 0.092 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr9_+_90112754 0.092 NM_004938
DAPK1
death-associated protein kinase 1
chrX_-_106960028 0.091 TSC22D3
TSC22 domain family, member 3
chr10_-_33623978 0.091 NRP1
neuropilin 1
chr16_+_4430878 0.091 VASN
vasorin
chr11_-_17565854 0.091 NM_005709
NM_153676
USH1C

Usher syndrome 1C (autosomal recessive, severe)

chr22_+_24891114 0.091 NM_016327
UPB1
ureidopropionase, beta
chr3_+_184038050 0.090 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr3_+_183894736 0.089 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr14_-_96829480 0.089 NM_018036
ATG2B
ATG2 autophagy related 2 homolog B (S. cerevisiae)
chr19_+_13842564 0.089 CCDC130
coiled-coil domain containing 130
chr6_+_31949800 0.089 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr1_-_173176314 0.089 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_+_70576447 0.089 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr16_-_79634610 0.089 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr7_-_100034050 0.089 NM_145030
PPP1R35
protein phosphatase 1, regulatory subunit 35
chr9_-_34691135 0.089 NM_006274
CCL19
chemokine (C-C motif) ligand 19
chr16_-_29910340 0.089 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr19_+_16435632 0.088 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr10_-_33623771 0.088 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr1_-_149908098 0.088 NM_181873
MTMR11
myotubularin related protein 11
chr11_-_64612040 0.088 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr14_+_95047792 0.087 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_-_74581934 0.087 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr5_+_127419407 0.087 NM_001046
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
chr3_+_48507621 0.087 TREX1
three prime repair exonuclease 1
chr15_+_80987953 0.087 FAM108C1
family with sequence similarity 108, member C1
chr3_+_50229022 0.087 NM_000172
NM_144499
GNAT1

guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

chr14_+_75536298 0.087 NM_001042430
NM_024643
FAM164C

family with sequence similarity 164, member C

chr7_-_156801980 0.086 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr19_+_15783827 0.086 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr6_+_116937641 0.086 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.