Motif ID: SPI1.p2

Z-value: 1.846


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1



Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_43299277 2.229 NM_005892
FMNL1
formin-like 1
chr1_-_183559463 1.610 NCF2
neutrophil cytosolic factor 2
chr1_-_183559669 1.518 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr22_-_31688329 1.463 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chrX_+_118892544 1.425 NM_001105576
ANKRD58
ankyrin repeat domain 58
chr12_+_56732658 1.351 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr1_-_183560010 1.340 NM_001127651
NCF2
neutrophil cytosolic factor 2
chrX_-_118925556 1.338 NM_001000
RPL39
ribosomal protein L39
chr1_+_186798031 1.289 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr15_+_41136622 1.252 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr10_+_82116557 1.171 NM_032372
DYDC2
DPY30 domain containing 2
chr12_-_49365545 1.124 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr6_+_36646489 1.103 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr6_+_33589045 1.023 NM_002224
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr1_-_6479880 1.017 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr16_+_29912146 0.923 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr16_-_74734687 0.921 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr6_+_36644236 0.886 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr6_+_36646455 0.881 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr5_-_172755195 0.880 STC2
stanniocalcin 2
chr1_-_168513201 0.876 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr1_-_147931877 0.864 FLJ39739
uncharacterized FLJ39739
chr4_+_79472851 0.851 ANXA3
annexin A3
chr6_+_54173202 0.847 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr5_-_172755418 0.842 STC2
stanniocalcin 2
chr12_+_52306112 0.818 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr3_-_164914448 0.799 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chrX_-_15872905 0.799


chr1_-_42965948 0.776 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr4_+_79472741 0.770 NM_005139
ANXA3
annexin A3
chr19_-_291335 0.764 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr6_-_154677868 0.763 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr6_+_139349877 0.760 C6orf115
chromosome 6 open reading frame 115
chr5_-_16617085 0.755 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr3_+_119500866 0.743 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr2_-_172967234 0.738 NM_004405
DLX2
distal-less homeobox 2
chr1_-_155178968 0.731 THBS3
thrombospondin 3
chr17_+_48638339 0.728 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr1_-_184943532 0.726 FAM129A
family with sequence similarity 129, member A
chr1_+_26737306 0.721 LIN28A
lin-28 homolog A (C. elegans)
chr1_-_1590403 0.720 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr16_+_15528324 0.718 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr6_+_31582978 0.716 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr6_-_31239489 0.711 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr12_+_57943780 0.708 KIF5A
kinesin family member 5A
chr8_+_22437983 0.698 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr6_-_32160289 0.697 GPSM3
G-protein signaling modulator 3
chr16_+_81812925 0.691 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr9_+_2622134 0.691 VLDLR
very low density lipoprotein receptor
chr19_-_49622278 0.686 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr21_+_26934440 0.679 MIR155HG
MIR155 host gene (non-protein coding)
chr5_-_172756505 0.676 NM_003714
STC2
stanniocalcin 2
chr1_-_168106535 0.675 GPR161
G protein-coupled receptor 161
chr3_+_119013216 0.671 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr12_-_26277807 0.671 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr4_-_109089444 0.669 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr11_+_71259465 0.666 NM_005553
KRTAP5-9
keratin associated protein 5-9
chr5_+_88185257 0.665 RPS6
ribosomal protein S6
chr19_+_41284068 0.661 NM_016154
RAB4B
RAB4B, member RAS oncogene family
chrX_-_15872871 0.657 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr5_-_72743829 0.653 FOXD1
forkhead box D1
chr5_+_174151531 0.645 NM_002449
MSX2
msh homeobox 2
chr6_-_29595746 0.643 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr1_-_36789754 0.641 NM_018166
FAM176B
family with sequence similarity 176, member B
chr20_-_22565050 0.639 NM_021784
FOXA2
forkhead box A2
chr12_-_123214882 0.638 NM_032554
HCAR1
hydroxycarboxylic acid receptor 1
chr4_+_84457256 0.630 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr17_+_56833231 0.630 NM_014906
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr19_+_48828820 0.623 EMP3
epithelial membrane protein 3
chr6_-_91006580 0.615 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr5_-_10353690 0.610


chr10_+_114154522 0.609 ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_8642309 0.608 NM_012335
MYO1F
myosin IF
chr22_-_37640187 0.606 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr12_-_58135853 0.604 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_+_111415791 0.600 CD53
CD53 molecule
chr20_+_44035203 0.597 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr1_-_168106727 0.597 GPR161
G protein-coupled receptor 161
chr7_+_18535817 0.596 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr7_-_150038689 0.596 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr3_-_52488030 0.595 NM_003280
TNNC1
troponin C type 1 (slow)
chr6_-_99797530 0.594 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr13_-_77460432 0.594 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr11_+_2920910 0.590 NM_183233
SLC22A18
solute carrier family 22, member 18
chr17_+_62075710 0.587 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr12_-_53600999 0.586 NM_000889
ITGB7
integrin, beta 7
chr10_-_98592186 0.586


chr12_-_53901371 0.581 NM_003717
NPFF
neuropeptide FF-amide peptide precursor
chr1_-_212873197 0.578 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr13_+_52027435 0.564


chr16_+_30419363 0.563 ZNF771
zinc finger protein 771
chr12_+_49212253 0.561 NM_000725
NM_001206915
CACNB3

calcium channel, voltage-dependent, beta 3 subunit

chr1_+_26644380 0.560 NM_001803
CD52
CD52 molecule
chr2_+_121103670 0.560 NM_002193
INHBB
inhibin, beta B
chr5_-_33891967 0.558 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chrX_-_15873094 0.557 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_74442185 0.556 NM_015424
CHRDL2
chordin-like 2
chrX_+_131352205 0.556


chr10_-_126849556 0.552 NM_001083914
CTBP2
C-terminal binding protein 2
chr7_-_124405680 0.551 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_1361507 0.551 NM_001146685
TMEM88B
transmembrane protein 88B
chrX_+_117629871 0.550 NM_144658
DOCK11
dedicator of cytokinesis 11
chr13_-_77460369 0.547 KCTD12
potassium channel tetramerisation domain containing 12
chr1_-_184943673 0.545 NM_052966
FAM129A
family with sequence similarity 129, member A
chr1_+_181003138 0.544 MR1
major histocompatibility complex, class I-related
chr15_+_85359910 0.542 NM_020778
ALPK3
alpha-kinase 3
chr2_-_28113211 0.536 NM_022128
RBKS
ribokinase
chr4_-_6911373 0.536


chr10_-_82116499 0.536 NM_138812
DYDC1
DPY30 domain containing 1
chr3_-_111851967 0.533 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr8_-_29206321 0.529 NM_057158
DUSP4
dual specificity phosphatase 4
chr12_+_52400725 0.527 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr6_+_139349818 0.526 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr14_-_75330535 0.525 NM_001080408
NM_001243007
PROX2

prospero homeobox 2

chr4_-_76944585 0.524 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr16_+_83986826 0.523 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr6_+_36098261 0.518 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr15_+_71839540 0.516 THSD4
thrombospondin, type I, domain containing 4
chr9_+_2622052 0.515 VLDLR
very low density lipoprotein receptor
chr8_+_120428551 0.514 NM_002514
NOV
nephroblastoma overexpressed gene
chr1_-_212873306 0.513 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr6_+_8435852 0.512 LOC100506207
uncharacterized LOC100506207
chr19_+_41284161 0.511 RAB4B-EGLN2
RAB4B
RAB4B-EGLN2 readthrough
RAB4B, member RAS oncogene family
chr5_-_138739755 0.506 NM_194296
SPATA24
spermatogenesis associated 24
chr8_-_67090690 0.505 NM_000756
CRH
corticotropin releasing hormone
chr6_-_154651214 0.501 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chrX_-_15872882 0.496 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr3_-_55521330 0.494 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr9_+_2622099 0.492 VLDLR
very low density lipoprotein receptor
chr12_-_13103317 0.490 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr16_-_30394133 0.489 NM_052838
SEPT1
septin 1
chr20_-_3765747 0.489 CENPB
centromere protein B, 80kDa
chr5_+_177540465 0.485 NM_015111
N4BP3
NEDD4 binding protein 3
chr4_+_41983712 0.483 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr16_+_81812899 0.482 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr4_+_88896801 0.480 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr5_-_72744351 0.478 NM_004472
FOXD1
forkhead box D1
chr12_+_21679190 0.477 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr4_+_88896838 0.477 SPP1
secreted phosphoprotein 1
chr16_+_81812897 0.475 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr4_+_88896868 0.472 SPP1
secreted phosphoprotein 1
chr7_+_43152196 0.471 NM_015052
HECW1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr16_+_330605 0.470 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr19_+_48828627 0.469 NM_001425
EMP3
epithelial membrane protein 3
chr17_+_7462064 0.465 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr17_-_43487747 0.463 ARHGAP27
Rho GTPase activating protein 27
chr3_+_32023265 0.463 NM_001137674
ZNF860
zinc finger protein 860
chr5_+_115298136 0.463 NM_173800
AQPEP
laeverin
chr12_+_50497790 0.462 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chrX_-_15872938 0.461 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr19_-_13213973 0.459 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr14_-_23285011 0.459 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr20_+_43514350 0.459 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr4_+_15004297 0.455 NM_001177381
NM_001177382
NM_001177383
NM_001177384
NM_182485
NM_182646
CPEB2





cytoplasmic polyadenylation element binding protein 2





chr1_+_111415721 0.454 NM_000560
CD53
CD53 molecule
chr17_+_41322413 0.453 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr4_+_142557722 0.452 NM_000585
NM_172175
IL15

interleukin 15

chr1_+_181003066 0.452 MR1
major histocompatibility complex, class I-related
chr19_-_13213669 0.452 LYL1
lymphoblastic leukemia derived sequence 1
chr5_+_172484353 0.450 C5orf41
chromosome 5 open reading frame 41
chr11_-_67120943 0.449 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr4_-_120548329 0.449 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chr12_-_104443698 0.447 GLT8D2
glycosyltransferase 8 domain containing 2
chr17_+_16318848 0.446 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr16_+_67686813 0.446 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr4_+_88896899 0.445 SPP1
secreted phosphoprotein 1
chr19_+_36203829 0.445 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr15_-_90222572 0.444 NM_001145311
NM_002666
PLIN1

perilipin 1

chr19_-_42569921 0.443 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr8_+_32405727 0.443 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chrX_+_135278912 0.442 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr1_-_108742806 0.441 SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr6_-_46138584 0.441 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr19_-_32896441 0.440 LOC400684
uncharacterized LOC400684
chr12_+_56510373 0.440 NM_001035267
NM_021104
RPL41

ribosomal protein L41

chr5_+_132209354 0.440 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr12_-_57505176 0.440 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chrX_+_102862833 0.440 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr19_-_36643770 0.438 NM_001864
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr12_+_104697460 0.436 NM_001008394
EID3
EP300 interacting inhibitor of differentiation 3
chr5_-_33892292 0.434 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr19_-_36523540 0.433 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr2_-_159312955 0.427 NM_001171637
NM_138803
CCDC148

coiled-coil domain containing 148

chr7_+_33945111 0.427 NM_133468
BMPER
BMP binding endothelial regulator
chr15_+_41136178 0.423 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chrX_-_47489243 0.422 NM_001145252
CFP
complement factor properdin
chr11_+_35160385 0.421 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr16_+_57576576 0.420 NM_153837
GPR114
G protein-coupled receptor 114
chr18_+_2846979 0.420 NM_032048
EMILIN2
elastin microfibril interfacer 2
chr1_+_206730591 0.420 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr10_-_62332666 0.419 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_+_18535351 0.419 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr6_-_111136330 0.419 CDK19
cyclin-dependent kinase 19
chr10_+_74033676 0.418 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chrX_+_99899388 0.418 SRPX2
sushi-repeat containing protein, X-linked 2
chr11_-_46142955 0.417 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chr1_+_181003143 0.416 MR1
major histocompatibility complex, class I-related
chr1_+_154300275 0.415 NM_020452
ATP8B2
ATPase, class I, type 8B, member 2
chr1_+_235491752 0.415 NM_001037277
GGPS1
geranylgeranyl diphosphate synthase 1
chrX_+_117957733 0.415 NM_173798
ZCCHC12
zinc finger, CCHC domain containing 12

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
324.83 2.35e-03 GO:0055093 response to hyperoxia
108.33 2.30e-02 GO:0070169 positive regulation of biomineral tissue development
86.68 3.61e-02 GO:0045778 positive regulation of ossification
11.32 4.23e-02 GO:0043065 positive regulation of apoptosis
11.25 4.33e-02 GO:0043068 positive regulation of programmed cell death
11.09 4.59e-02 GO:0008284 positive regulation of cell proliferation
11.06 4.62e-02 GO:0010942 positive regulation of cell death

Nothing significant found in compartment category.

Nothing significant found in function category.