Motif ID: SREBF1,2.p2

Z-value: 0.784


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SREBF1hg19_v1_chr17_-_17726855_17726954-0.992.7e-04Click!
SREBF2hg19_v1_chr22_+_42229268_42229274-0.815.1e-02Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_212873306 0.984 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr1_-_212873197 0.954 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr1_+_150255228 0.671 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr1_-_212873104 0.649 BATF3
basic leucine zipper transcription factor, ATF-like 3
chrX_-_100662905 0.495 NM_000169
GLA
galactosidase, alpha
chr22_+_42394728 0.492 NM_152613
WBP2NL
WBP2 N-terminal like
chr7_+_28448970 0.482 LOC401317
uncharacterized LOC401317
chr2_-_172967234 0.463 NM_004405
DLX2
distal-less homeobox 2
chr4_+_77135192 0.457 NM_001242936
FAM47E
family with sequence similarity 47, member E
chr2_-_238499317 0.452 RAB17
RAB17, member RAS oncogene family
chr17_+_79885567 0.446 LOC92659
uncharacterized LOC92659
chr12_-_105501410 0.445 LOC414300
uncharacterized LOC414300
chrX_-_100662788 0.440 GLA
galactosidase, alpha
chr19_-_49016418 0.418 NM_001080434
LMTK3
lemur tyrosine kinase 3
chr9_-_140009194 0.417 NM_013379
DPP7
dipeptidyl-peptidase 7
chr9_-_37904098 0.411 MCART1
mitochondrial carrier triple repeat 1
chr18_+_9708187 0.399 NM_006868
RAB31
RAB31, member RAS oncogene family
chr4_+_100871625 0.387 LOC256880
uncharacterized LOC256880
chr12_-_56122840 0.385 NM_001040034
NM_001780
CD63

CD63 molecule

chrX_+_102862833 0.378 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr1_+_11866302 0.371 CLCN6
chloride channel 6
chr4_-_23891608 0.366 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr19_-_291335 0.363 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chrX_+_77166178 0.363 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr9_+_116111811 0.359 NM_017688
BSPRY
B-box and SPRY domain containing
chr16_+_81812925 0.352 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr7_+_99775521 0.349 NM_012447
STAG3
stromal antigen 3
chr19_+_50922194 0.347 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr1_-_153521717 0.342 NM_002960
S100A3
S100 calcium binding protein A3
chr3_-_124931562 0.341 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr1_-_201368434 0.339 LAD1
ladinin 1
chr11_+_9685624 0.332 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chrX_-_102531673 0.331 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr2_-_46747095 0.331 NM_080653
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr8_+_26240522 0.329 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr22_+_38599026 0.321 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr6_-_99797530 0.320 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr7_-_27142301 0.318 NM_006735
HOXA2
homeobox A2
chr12_+_54426831 0.317 NM_018953
HOXC5
homeobox C5
chr8_+_71581599 0.316 NM_001011720
XKR9
XK, Kell blood group complex subunit-related family, member 9
chr3_+_5021141 0.315 BHLHE40
basic helix-loop-helix family, member e40
chr3_+_5021096 0.315 NM_003670
BHLHE40
basic helix-loop-helix family, member e40
chr12_-_56122800 0.312 CD63
CD63 molecule
chr1_+_92414927 0.309 NM_001242805
NM_001242806
NM_001242807
NM_001242808
NM_001242810
NM_207189
BRDT





bromodomain, testis-specific





chr1_-_153508597 0.308 NM_014624
S100A6
S100 calcium binding protein A6
chr6_+_139349818 0.306 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr18_-_21017816 0.304 NM_032933
TMEM241
transmembrane protein 241
chr16_+_71660063 0.298 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr12_+_7023490 0.298 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr6_+_151561094 0.297 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_56122792 0.296 CD63
CD63 molecule
chr18_+_9136742 0.294 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr11_+_59522801 0.292 STX3
syntaxin 3
chr9_+_103235489 0.291 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr9_+_103235634 0.289 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr8_+_59465727 0.288 NM_001007067
NM_001007068
NM_001007069
NM_001007070
NM_005625
SDCBP




syndecan binding protein (syntenin)




chr5_+_80256457 0.287 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr11_+_9685650 0.286 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr6_+_151646634 0.286 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_26737306 0.285 LIN28A
lin-28 homolog A (C. elegans)
chr19_-_10764449 0.285 LOC147727
uncharacterized LOC147727
chr6_-_90121656 0.284 RRAGD
Ras-related GTP binding D
chr15_-_40213087 0.284 NM_007223
GPR176
G protein-coupled receptor 176
chr15_+_89182038 0.281 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr5_+_41904459 0.278 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr12_-_56122748 0.278 CD63
CD63 molecule
chrX_-_15872905 0.277


chr6_-_90121966 0.276 NM_021244
RRAGD
Ras-related GTP binding D
chr6_-_151773168 0.275 NM_017909
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr16_+_5083671 0.274 LOC100507589
uncharacterized LOC100507589
chrX_-_15872871 0.272 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr17_-_63052744 0.269 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr11_+_61717355 0.269 NM_001139443
NM_004183
BEST1

bestrophin 1

chr20_-_56884488 0.268 PPP4R1L
protein phosphatase 4, regulatory subunit 1-like
chr5_-_172198160 0.267 NM_004417
DUSP1
dual specificity phosphatase 1
chr2_+_239047362 0.263 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr5_+_172483285 0.261 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr17_+_80332152 0.260 NM_018949
UTS2R
urotensin 2 receptor
chr16_+_81812899 0.260 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr16_+_81812897 0.258 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr18_+_77866914 0.254 NM_014913
ADNP2
ADNP homeobox 2
chr15_-_50978960 0.253 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr12_-_10021932 0.253 CLEC2B
C-type lectin domain family 2, member B
chr6_-_33385662 0.251 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr5_+_59784004 0.248 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr9_+_6757636 0.247 NM_001146694
NM_001146695
NM_015061
KDM4C


lysine (K)-specific demethylase 4C


chr5_-_131132690 0.247 FNIP1
folliculin interacting protein 1
chr9_+_103115342 0.247


chr8_+_126104082 0.246 NM_173685
NSMCE2
non-SMC element 2, MMS21 homolog (S. cerevisiae)
chr11_-_61684981 0.246 NM_013401
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr14_+_24641204 0.244 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr12_-_49463729 0.244 NM_144593
RHEBL1
Ras homolog enriched in brain like 1
chr17_+_45401269 0.244 NM_001195192
NM_152347
C17orf57

chromosome 17 open reading frame 57

chr8_-_95274540 0.243 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr6_+_99872769 0.242


chr7_-_27205123 0.242 HOXA9
homeobox A9
chr1_+_201476283 0.242


chr5_-_131132642 0.239 FNIP1
folliculin interacting protein 1
chr1_+_11866240 0.239 CLCN6
chloride channel 6
chr6_-_90121911 0.238 RRAGD
Ras-related GTP binding D
chr17_-_63052884 0.236 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr13_+_52027435 0.236


chr22_-_41593466 0.236


chr8_+_25042066 0.236 DOCK5
dedicator of cytokinesis 5
chr6_-_33714681 0.235 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr4_-_99850280 0.235 EIF4E
eukaryotic translation initiation factor 4E
chr19_+_45504686 0.235 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr14_-_35591439 0.234 NM_017917
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr9_-_90589360 0.232 CDK20
cyclin-dependent kinase 20
chr11_-_85780088 0.232 PICALM
phosphatidylinositol binding clathrin assembly protein
chr10_-_3827418 0.231 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr5_-_131132715 0.231 NM_001008738
NM_133372
FNIP1

folliculin interacting protein 1

chr8_+_59465818 0.230 SDCBP
syndecan binding protein (syntenin)
chr8_+_1772095 0.230 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr11_+_9685606 0.230 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr9_-_104249333 0.229 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr6_+_139349877 0.228 C6orf115
chromosome 6 open reading frame 115
chrX_+_100663205 0.228 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chrX_+_100663120 0.228 NM_001032393
NM_019597
HNRNPH2

heterogeneous nuclear ribonucleoprotein H2 (H')

chr17_+_25621105 0.227 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr8_+_59465798 0.226 SDCBP
syndecan binding protein (syntenin)
chr8_+_21881587 0.225 NPM2
nucleophosmin/nucleoplasmin 2
chrX_+_100805415 0.225 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chrX_+_77166223 0.222 ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr18_+_9708322 0.221 RAB31
RAB31, member RAS oncogene family
chr14_-_64761077 0.220 NM_001040275
NM_001437
ESR2

estrogen receptor 2 (ER beta)

chr9_-_90589593 0.220 NM_001039803
NM_001170639
NM_001170640
NM_012119
NM_178432
CDK20




cyclin-dependent kinase 20




chr8_-_95274520 0.219 GEM
GTP binding protein overexpressed in skeletal muscle
chr12_-_123380628 0.218 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr6_+_7726268 0.218 BMP6
bone morphogenetic protein 6
chr10_-_76995685 0.215 NM_144589
COMTD1
catechol-O-methyltransferase domain containing 1
chr19_+_8386374 0.215 NM_001031
RPS28
ribosomal protein S28
chr7_-_130792839 0.213 FLJ43663
uncharacterized LOC378805
chr4_-_47465646 0.211 NM_017845
COMMD8
COMM domain containing 8
chr20_-_656443 0.210


chr1_+_11866206 0.209 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr9_-_140009162 0.209 DPP7
dipeptidyl-peptidase 7
chrX_+_100663229 0.208 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr2_+_26395959 0.208 NM_001168241
FAM59B
family with sequence similarity 59, member B
chr6_-_33385814 0.208


chr7_-_559030 0.207 PDGFA
platelet-derived growth factor alpha polypeptide
chr15_-_50978983 0.207 NM_017672
TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr9_-_37576248 0.206 NM_012166
FBXO10
F-box protein 10
chr11_-_85780105 0.205 NM_001008660
NM_001206946
NM_007166
PICALM


phosphatidylinositol binding clathrin assembly protein


chr16_+_87425874 0.205 MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
chr9_-_140009169 0.205 DPP7
dipeptidyl-peptidase 7
chr1_-_11866079 0.203 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr15_+_69591272 0.203 NM_017705
PAQR5
progestin and adipoQ receptor family member V
chr17_-_17140492 0.201 NM_144606
NM_144997
FLCN

folliculin

chr1_-_201368617 0.201 NM_005558
LAD1
ladinin 1
chr17_-_17109601 0.201 PLD6
phospholipase D family, member 6
chr5_-_131132709 0.200 FNIP1
folliculin interacting protein 1
chr4_-_47465719 0.199 COMMD8
COMM domain containing 8
chr17_-_63052816 0.199


chr18_+_77867145 0.197 ADNP2
ADNP homeobox 2
chr17_-_17109630 0.196 NM_178836
PLD6
phospholipase D family, member 6
chr16_-_81129882 0.196 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr11_+_9685653 0.195 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr7_+_150102376 0.195


chr14_+_76044939 0.195 NM_017791
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr8_-_95961543 0.193 NM_001135733
NM_033285
TP53INP1

tumor protein p53 inducible nuclear protein 1

chr7_-_27205148 0.193 NM_152739
HOXA9
homeobox A9
chr7_-_150721551 0.193 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr3_-_170626381 0.192 EIF5A2
eukaryotic translation initiation factor 5A2
chr16_+_87425946 0.192 MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
chr17_+_76126835 0.191 NM_152468
TMC8
transmembrane channel-like 8
chr3_+_184529871 0.191 NM_001009921
NM_015303
VPS8

vacuolar protein sorting 8 homolog (S. cerevisiae)

chr16_+_87425998 0.188 MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
chr2_+_208576446 0.188 CCNYL1
cyclin Y-like 1
chr11_-_85779821 0.187 PICALM
phosphatidylinositol binding clathrin assembly protein
chr11_+_59522905 0.186 STX3
syntaxin 3
chr4_+_78078394 0.186 CCNG2
cyclin G2
chr4_-_103266396 0.185 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr22_+_31556197 0.185 RNF185
ring finger protein 185
chr7_-_112758604 0.185 LOC401397
uncharacterized LOC401397
chr8_+_59465783 0.184 SDCBP
syndecan binding protein (syntenin)
chr5_-_132299248 0.184 AFF4
AF4/FMR2 family, member 4
chr5_-_72744351 0.184 NM_004472
FOXD1
forkhead box D1
chr3_-_170626425 0.183 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr6_-_80656870 0.183 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr5_+_89854610 0.183 NM_032119
GPR98
G protein-coupled receptor 98
chrX_-_15872938 0.182 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_172410762 0.181 NM_003945
ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr11_+_9595429 0.180 WEE1
WEE1 homolog (S. pombe)
chr3_-_8693723 0.179 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr5_+_88185257 0.179 RPS6
ribosomal protein S6
chr1_-_33813261 0.178


chr16_+_30960413 0.177 ORAI3
ORAI calcium release-activated calcium modulator 3
chr11_+_9595309 0.176 WEE1
WEE1 homolog (S. pombe)
chr7_+_99775346 0.175 STAG3
stromal antigen 3
chr2_-_85108202 0.175 C2orf89
chromosome 2 open reading frame 89
chr13_+_21872248 0.175 MIPEPP3
mitochondrial intermediate peptidase pseudogene 3
chr8_-_54755836 0.174 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr21_+_30671227 0.174 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr11_+_18720281 0.173 TMEM86A
transmembrane protein 86A
chr1_+_181002560 0.173 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr17_+_45401141 0.172 C17orf57
chromosome 17 open reading frame 57
chr12_-_118498893 0.172 NM_018639
WSB2
WD repeat and SOCS box containing 2
chr6_-_10694837 0.172 NM_001145020
C6orf52
chromosome 6 open reading frame 52
chr4_+_159131642 0.171 TMEM144
transmembrane protein 144

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.