Motif ID: TBP.p2

Z-value: 2.232


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBPhg19_v1_chr6_+_170863420_1708635080.285.9e-01Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_35773409 3.860 NM_021175
HAMP
hepcidin antimicrobial peptide
chr6_-_26043884 3.318 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr17_-_70588942 2.345 LOC100499467
uncharacterized LOC100499467
chr6_+_26217145 2.299 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr6_+_27114860 2.023 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr4_+_74735107 1.986 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr15_-_75017710 1.967 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chrX_-_115594136 1.946 NM_001017978
CXorf61
chromosome X open reading frame 61
chr6_+_26021906 1.826 NM_003538
HIST1H4A
histone cluster 1, H4a
chr6_-_27775683 1.755 NM_003519
HIST1H2BL
histone cluster 1, H2bl
chr6_-_26032287 1.750 NM_003537
HIST1H3B
histone cluster 1, H3b
chrX_-_105282714 1.476 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr10_-_92680784 1.463 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr20_-_39317875 1.394 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_-_156675237 1.247 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr16_+_56659679 1.169 MT1E
metallothionein 1E
chr3_-_169482847 1.156 TERC
telomerase RNA component
chr16_+_56659584 1.141 NM_175617
MT1E
metallothionein 1E
chr1_+_149858466 1.117 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr5_-_27038650 1.108 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr6_+_27775898 1.107 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr16_+_72097124 1.105 NM_020995
HPR
haptoglobin-related protein
chr16_-_67965754 1.025 NM_001907
CTRL
chymotrypsin-like
chr1_-_11918889 1.018 NM_002521
NPPB
natriuretic peptide B
chr9_-_33447527 0.949 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr16_-_56701904 0.926 NM_005950
MT1G
metallothionein 1G
chr7_+_94285620 0.887 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr7_+_94285736 0.884 PEG10
paternally expressed 10
chr6_+_27833033 0.877 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr6_-_26124130 0.871 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr11_-_116693907 0.865 NM_000482
APOA4
apolipoprotein A-IV
chr6_+_27100784 0.865 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr7_+_94285676 0.853 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr5_+_176811431 0.809 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr6_+_26045611 0.808 NM_003531
HIST1H3C
histone cluster 1, H3c
chr6_-_26017960 0.794 NM_005325
HIST1H1A
histone cluster 1, H1a
chr16_+_56716378 0.778 NM_005952
MT1X
metallothionein 1X
chr1_-_11907741 0.765 NM_006172
NPPA
natriuretic peptide A
chr4_+_74606222 0.750 NM_000584
IL8
interleukin 8
chr6_+_12290528 0.734 NM_001168319
NM_001955
EDN1

endothelin 1

chr22_+_24115035 0.709 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chrX_+_17393537 0.703 NM_198270
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr11_+_1718424 0.698 NM_001012416
KRTAP5-6
keratin associated protein 5-6
chr11_-_2182408 0.680 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough
chr6_+_27861202 0.673 NM_003527
HIST1H2BO
histone cluster 1, H2bo
chr15_+_39873276 0.648 NM_003246
THBS1
thrombospondin 1
chr10_-_92681025 0.642 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr10_+_6244839 0.636 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr6_-_27860927 0.628 NM_003514
HIST1H2AM
histone cluster 1, H2am
chr9_+_117085302 0.626 NM_000607
ORM1
orosomucoid 1
chr6_-_134498973 0.625 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr10_+_96698409 0.620 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr1_-_149858114 0.618 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr13_+_27844936 0.610 RASL11A
RAS-like, family 11, member A
chr11_-_18270167 0.610 NM_001199744
NM_001127380
NM_030754
SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr9_+_33240165 0.608 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr21_-_31852631 0.599 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr1_-_149783910 0.589 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr21_-_43786602 0.588 NM_003225
TFF1
trefoil factor 1
chr19_+_859658 0.576 NM_001928
CFD
complement factor D (adipsin)
chr4_+_155484131 0.568 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr10_-_72201438 0.562 NM_018055
NODAL
nodal homolog (mouse)
chr11_+_67183144 0.557 NM_001166222
NM_020811
CARNS1

carnosine synthase 1

chr12_-_11036815 0.557 NM_006250
PRH1
proline-rich protein HaeIII subfamily 1
chr6_-_26216871 0.553 NM_003518
HIST1H2BG
NCALD
histone cluster 1, H2bg
neurocalcin delta
chr1_+_86046434 0.547 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr1_+_154966061 0.547 NM_018655
LENEP
lens epithelial protein
chr7_+_44836309 0.529 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr9_-_104198045 0.522 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr10_+_54074037 0.520 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr2_+_8822112 0.509 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr15_-_51630735 0.508 NM_000103
NM_031226
CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1

chr1_-_23885916 0.507 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr18_+_29171729 0.507 NM_000371
TTR
transthyretin
chr9_-_5437825 0.493 NM_018465
C9orf46
chromosome 9 open reading frame 46
chr17_+_7387688 0.486 NM_000937
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr17_+_79008945 0.479 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr19_+_49468587 0.466 FTL
ferritin, light polypeptide
chr19_+_1269244 0.464 NM_001280
CIRBP
cold inducible RNA binding protein
chr20_+_47895178 0.451 ZNFX1-AS1
ZNFX1 antisense RNA 1 (non-protein coding)
chr1_-_27481400 0.451 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr1_-_149785235 0.448 NM_001123375
HIST2H3D
histone cluster 2, H3d
chr2_-_43453724 0.445 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr22_+_35777051 0.441 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr7_-_73097729 0.429 NM_032317
DNAJC30
DnaJ (Hsp40) homolog, subfamily C, member 30
chr6_+_26204779 0.427 NM_003545
HIST1H4E
histone cluster 1, H4e
chr2_-_43453146 0.417 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr22_+_31480981 0.415 NM_001207018
SMTN
smoothelin
chr6_+_14118002 0.414 CD83
CD83 molecule
chr15_+_69745156 0.414 NM_001003
NM_213725
RPLP1

ribosomal protein, large, P1

chr11_-_615920 0.414 IRF7
interferon regulatory factor 7
chr16_+_56691854 0.414 NM_005949
MT1F
metallothionein 1F
chr19_-_33793321 0.403


chr2_-_228244005 0.401 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr6_+_26020677 0.398 NM_003529
HIST1H3A
histone cluster 1, H3a
chr15_-_55800431 0.396 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr19_+_16435632 0.388 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr7_-_45960738 0.383 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr4_+_119199906 0.383 SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr17_+_79008958 0.379 BAIAP2
BAI1-associated protein 2
chr12_-_53298765 0.378 NM_002273
KRT8
keratin 8
chr9_+_92219926 0.377 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr7_+_157023933 0.377


chr12_+_101988746 0.369 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr19_+_49468557 0.365 NM_000146
FTL
ferritin, light polypeptide
chr6_+_26124372 0.358 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr16_+_89989686 0.352 NM_006086
TUBB3
tubulin, beta 3 class III
chr14_-_21493910 0.348 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr21_-_31859666 0.347 NM_181608
KRTAP19-2
keratin associated protein 19-2
chr7_-_128415843 0.340 NM_001708
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chrX_+_46940235 0.340 RGN
regucalcin (senescence marker protein-30)
chr3_+_193853930 0.333 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr6_-_27835308 0.332 NM_005322
HIST1H1B
histone cluster 1, H1b
chr1_-_89357181 0.331 GTF2B
general transcription factor IIB
chr7_-_16505292 0.328 NM_015464
SOSTDC1
sclerostin domain containing 1
chr6_+_36562135 0.327 SRSF3
serine/arginine-rich splicing factor 3
chr6_+_31802644 0.326 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr1_-_95007139 0.318 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr7_+_94297448 0.317 PEG10
paternally expressed 10
chr6_-_2842069 0.314 NM_030666
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr7_-_5570188 0.313 NM_001101
ACTB
actin, beta
chr19_-_12912602 0.309 NM_005809
NM_181738
PRDX2

peroxiredoxin 2

chr15_-_102029872 0.308 PCSK6
proprotein convertase subtilisin/kexin type 6
chr7_+_116593554 0.306 ST7
suppression of tumorigenicity 7
chr17_-_73150493 0.305 HN1
hematological and neurological expressed 1
chr7_+_100026412 0.304 NM_001194990
NM_001194991
NM_001194992
MEPCE


methylphosphate capping enzyme


chr1_-_226076766 0.304 NM_020997
LEFTY1
left-right determination factor 1
chr11_-_111782447 0.302 NM_001885
CRYAB
crystallin, alpha B
chr19_-_45826131 0.301 CKM
creatine kinase, muscle
chr7_-_16844606 0.301 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr3_+_49449638 0.299 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr9_+_131314669 0.298 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr6_-_26235160 0.292 NM_005320
HIST1H1D
histone cluster 1, H1d
chr17_+_43225834 0.290 HEXIM1
hexamethylene bis-acetamide inducible 1
chrM_+_5769 0.289


chr11_-_6462129 0.287 NM_000613
HPX
hemopexin
chr6_-_133035180 0.286 NM_004666
VNN1
vanin 1
chr6_-_86388419 0.286 SNHG5
small nucleolar RNA host gene 5 (non-protein coding)
chr17_+_7554711 0.284 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr3_+_149192479 0.283 TM4SF4
transmembrane 4 L six family member 4
chr10_-_100027943 0.281 NM_032211
LOXL4
lysyl oxidase-like 4
chr7_+_75931991 0.281 HSPB1
heat shock 27kDa protein 1
chr21_-_43735705 0.280 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr4_+_86851425 0.280 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr8_+_86376130 0.280 NM_000067
CA2
carbonic anhydrase II
chr8_-_95907423 0.279 NM_057749
CCNE2
cyclin E2
chr19_-_6720585 0.279 NM_000064
C3
complement component 3
chr19_-_41356193 0.278 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr19_-_2051222 0.274 NM_017572
NM_199054
MKNK2

MAP kinase interacting serine/threonine kinase 2

chr4_-_74904329 0.274 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chrM_+_5513 0.271


chr11_+_61129407 0.271 NM_016464
TMEM138
transmembrane protein 138
chr20_-_44540685 0.270 PLTP
phospholipid transfer protein
chr22_-_36236330 0.269 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr19_+_41497182 0.268 NM_000767
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr14_+_93389491 0.268 CHGA
chromogranin A (parathyroid secretory protein 1)
chr5_-_57755787 0.268 NM_001252226
NM_006622
PLK2

polo-like kinase 2

chr16_+_57406398 0.267 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr3_-_49395751 0.267 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chrX_+_38663450 0.267 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr6_+_32006092 0.266 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr7_+_116593354 0.263 NM_018412
NM_021908
ST7

suppression of tumorigenicity 7

chr7_+_113726490 0.261 FOXP2
forkhead box P2
chr19_+_2476122 0.259 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr17_+_7554415 0.259 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr2_-_151344145 0.259 NM_005168
RND3
Rho family GTPase 3
chr7_+_100026413 0.259 MEPCE
methylphosphate capping enzyme
chr3_+_193853937 0.257 HES1
hairy and enhancer of split 1, (Drosophila)
chr6_-_26108320 0.252 NM_005323
HIST1H1T
histone cluster 1, H1t
chr11_-_116708334 0.251 NM_000039
APOA1
apolipoprotein A-I
chr6_+_64281910 0.247 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr15_-_45670624 0.247 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr10_-_62703822 0.246 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr7_+_143013218 0.244 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr6_+_27777713 0.244 NM_003536
HIST1H3H
histone cluster 1, H3h
chrX_+_153626570 0.242 NM_006013
RPL10
ribosomal protein L10
chr6_-_27114577 0.239 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr11_+_75273245 0.239 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr9_+_117092068 0.237 NM_000608
ORM2
orosomucoid 2
chr2_+_10262853 0.236 NM_001034
RRM2
ribonucleotide reductase M2
chr7_-_134143804 0.235 AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr20_+_30193083 0.234 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr1_-_230849863 0.231 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr11_-_615649 0.229 NM_004031
IRF7
interferon regulatory factor 7
chr11_+_60635014 0.228 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr2_-_162930629 0.226 DPP4
dipeptidyl-peptidase 4
chr11_+_2398543 0.226 NM_004356
CD81
CD81 molecule
chr15_+_75041182 0.226 NM_000761
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr15_-_85201417 0.225 NMB
neuromedin B
chr2_-_97509733 0.225 NM_144994
ANKRD23
ankyrin repeat domain 23
chr7_+_112120907 0.223 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr6_-_135271206 0.222 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr11_-_111249902 0.222 POU2AF1
POU class 2 associating factor 1
chr4_-_46391393 0.219 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr2_+_39893021 0.218 NM_152390
TMEM178
transmembrane protein 178
chr1_-_230849847 0.214 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr12_-_56359794 0.213 NM_001200053
NM_001200054
PMEL

premelanosome protein

chr1_-_201465700 0.211 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr5_-_42811959 0.210 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chrM_+_5245 0.209



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
63.89 1.21e-11 GO:0006334 nucleosome assembly
60.60 1.87e-11 GO:0031497 chromatin assembly
57.63 2.83e-11 GO:0034728 nucleosome organization
55.46 3.89e-11 GO:0065004 protein-DNA complex assembly
52.49 6.10e-11 GO:0071824 protein-DNA complex subunit organization
46.29 1.70e-10 GO:0006323 DNA packaging
43.55 2.80e-10 GO:0006333 chromatin assembly or disassembly
39.73 5.90e-10 GO:0071103 DNA conformation change
17.47 4.16e-07 GO:0034622 cellular macromolecular complex assembly
13.74 2.74e-06 GO:0006325 chromatin organization
13.13 3.90e-06 GO:0034621 cellular macromolecular complex subunit organization
9.82 5.32e-06 GO:0071844 cellular component assembly at cellular level
10.57 2.08e-05 GO:0051276 chromosome organization
9.31 5.51e-05 GO:0065003 macromolecular complex assembly
7.00 9.62e-05 GO:0022607 cellular component assembly
7.80 2.10e-04 GO:0043933 macromolecular complex subunit organization
6.25 2.48e-04 GO:0044085 cellular component biogenesis
4.59 3.15e-03 GO:0006996 organelle organization
3.17 2.40e-02 GO:0071842 cellular component organization at cellular level
3.06 3.25e-02 GO:0071841 cellular component organization or biogenesis at cellular level
2.72 3.94e-02 GO:0016043 cellular component organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
97.94 1.26e-13 GO:0000786 nucleosome
61.87 5.86e-12 GO:0032993 protein-DNA complex
25.58 7.54e-09 GO:0000785 chromatin
13.42 1.22e-06 GO:0044427 chromosomal part
11.25 4.78e-06 GO:0005694 chromosome
2.50 3.10e-02 GO:0032991 macromolecular complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.41 2.29e-03 GO:0003677 DNA binding