Motif ID: YY1.p2

Z-value: 3.552


Transcription factors associated with YY1.p2:

Gene SymbolEntrez IDGene Name
YY1 7528 YY1 transcription factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
YY1hg19_v1_chr14_+_100705279_100705345-0.853.2e-02Click!


Activity profile for motif YY1.p2.

activity profile for motif YY1.p2


Sorted Z-values histogram for motif YY1.p2

Sorted Z-values for motif YY1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of YY1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_26217145 4.713 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr16_-_1821503 4.500 NME3
non-metastatic cells 3, protein expressed in
chr6_+_27775898 4.443 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr6_+_26045611 3.843 NM_003531
HIST1H3C
histone cluster 1, H3c
chr1_-_99470177 3.827 NM_001010861
NM_001037317
LPPR5

lipid phosphate phosphatase-related protein type 5

chr1_-_211751719 3.506 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr6_-_27775683 3.397 NM_003519
HIST1H2BL
histone cluster 1, H2bl
chr6_-_26027479 3.160 NM_003544
HIST1H4B
histone cluster 1, H4b
chr6_-_26032287 2.963 NM_003537
HIST1H3B
histone cluster 1, H3b
chr6_+_27833033 2.654 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr1_-_211751953 2.584 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr6_-_26043884 2.369 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr6_+_26199712 2.335 NM_003522
HIST1H2BF
histone cluster 1, H2bf
chr20_-_44563573 2.252 FLJ40606
uncharacterized LOC643549
chr6_-_27840086 2.217 NM_003533
HIST1H3I
histone cluster 1, H3i
chr3_+_149689065 2.179 LOC646903
uncharacterized LOC646903
chr19_+_17326154 2.136 NM_018467
USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr2_+_54952148 2.115 NM_001039753
EML6
echinoderm microtubule associated protein like 6
chr17_-_70588942 2.027 LOC100499467
uncharacterized LOC100499467
chr6_+_27114860 1.987 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chrX_+_142967172 1.975 NM_001012989
UBE2NL
ubiquitin-conjugating enzyme E2N-like
chr6_+_27861202 1.971 NM_003527
HIST1H2BO
histone cluster 1, H2bo
chr4_+_151503076 1.957 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr1_-_211752052 1.941 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr15_-_53082087 1.934 NM_004498
ONECUT1
one cut homeobox 1
chr7_-_1498961 1.917 MICALL2
MICAL-like 2
chr2_-_241835572 1.855 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr19_+_35773409 1.775 NM_021175
HAMP
hepcidin antimicrobial peptide
chr19_+_17326196 1.644 USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr6_-_27835308 1.621 NM_005322
HIST1H1B
histone cluster 1, H1b
chr7_-_1499107 1.618 NM_182924
MICALL2
MICAL-like 2
chr2_+_44066102 1.584 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr19_+_1270926 1.509 CIRBP
cold inducible RNA binding protein
chr10_+_71812536 1.495 H2AFY2
H2A histone family, member Y2
chrX_+_122318095 1.490 NM_000828
NM_007325
GRIA3

glutamate receptor, ionotrophic, AMPA 3

chr20_-_39317875 1.417 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_+_170115187 1.415 NM_001136107
METTL11B
methyltransferase like 11B
chr16_-_1821709 1.373 NM_002513
NME3
non-metastatic cells 3, protein expressed in
chr9_-_134955243 1.369 NM_004269
CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr10_-_33623299 1.367 NRP1
neuropilin 1
chr14_+_62462540 1.358 NM_031914
SYT16
synaptotagmin XVI
chr11_-_106888829 1.294 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr2_-_219925237 1.287 NM_002181
IHH
Indian hedgehog
chr6_-_27860927 1.258 NM_003514
HIST1H2AM
histone cluster 1, H2am
chr11_+_124120422 1.249 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr16_+_67233013 1.249 NM_024712
ELMO3
engulfment and cell motility 3
chr3_+_51989329 1.233 NM_080865
GPR62
G protein-coupled receptor 62
chr10_-_14879967 1.230 NM_001029954
CDNF
cerebral dopamine neurotrophic factor
chr1_+_38259458 1.223 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chr4_-_159092509 1.217 FAM198B
family with sequence similarity 198, member B
chr1_-_98386458 1.186 DPYD
dihydropyrimidine dehydrogenase
chr1_-_149858114 1.160 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr13_-_67804432 1.155 NM_020403
NM_203487
PCDH9

protocadherin 9

chr4_-_146859960 1.154


chr16_-_4852571 1.150 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr11_+_45907198 1.149 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr6_-_26216871 1.137 NM_003518
HIST1H2BG
NCALD
histone cluster 1, H2bg
neurocalcin delta
chr18_-_53068942 1.132


chr20_-_50179167 1.096 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chrX_-_153236621 1.095 NM_005334
HCFC1
host cell factor C1 (VP16-accessory protein)
chr19_+_7895110 1.094 NM_145245
EVI5L
ecotropic viral integration site 5-like
chr17_-_8066254 1.078 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr20_+_12989616 1.075 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr2_-_73928466 1.073 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr7_+_128312345 1.062 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr6_+_26183957 1.059 NM_003523
HIST1H2BE
histone cluster 1, H2be
chr13_-_24471124 1.045 NM_001007537
C1QTNF9B
C1q and tumor necrosis factor related protein 9B
chr17_-_56296587 1.044 NM_017777
MKS1
Meckel syndrome, type 1
chr17_+_56065408 1.043


chr6_-_2751153 1.042 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr1_+_164528914 1.040 PBX1
pre-B-cell leukemia homeobox 1
chr20_-_44516237 1.037 NM_080608
SPATA25
spermatogenesis associated 25
chr1_-_149783910 1.035 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr13_+_21750752 1.034 MRP63
mitochondrial ribosomal protein 63
chr10_+_105005643 1.019 NM_001143909
LOC729020
rcRPE
chr17_+_71189186 1.018 COG1
component of oligomeric golgi complex 1
chr1_+_38261079 1.013 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr1_-_98386594 1.013 NM_000110
NM_001160301
DPYD

dihydropyrimidine dehydrogenase

chr1_-_161102457 1.012 NM_001039711
NM_032998
DEDD

death effector domain containing

chr10_+_75673346 1.006 PLAU
plasminogen activator, urokinase
chr3_-_190040192 1.000 NM_021101
CLDN1
claudin 1
chr6_-_26033795 1.000 NM_003513
HIST1H2AB
histone cluster 1, H2ab
chr1_-_98386525 0.991 DPYD
dihydropyrimidine dehydrogenase
chr1_-_149900143 0.990 NM_005850
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr11_-_66115016 0.984 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr17_-_42081836 0.977 NM_004160
PYY
peptide YY
chr11_+_77532159 0.977 NM_024684
C11orf67
chromosome 11 open reading frame 67
chr17_+_71189144 0.972 NM_018714
COG1
component of oligomeric golgi complex 1
chr1_+_1266722 0.965 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr11_+_66045645 0.964 NM_182553
CNIH2
cornichon homolog 2 (Drosophila)
chr1_+_149858466 0.964 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr20_-_5100443 0.960 NM_182649
PCNA
proliferating cell nuclear antigen
chr17_+_42081913 0.957 NM_153006
NAGS
N-acetylglutamate synthase
chr1_+_226411318 0.955 NM_031944
MIXL1
Mix paired-like homeobox
chr17_+_4046941 0.935 CYB5D2
cytochrome b5 domain containing 2
chr18_-_5892102 0.935 NM_001080209
TMEM200C
transmembrane protein 200C
chr2_+_63277936 0.922 NM_014562
OTX1
orthodenticle homeobox 1
chr6_+_27806322 0.916 NM_003520
HIST1H2BN
histone cluster 1, H2bn
chr15_-_75017710 0.908 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr1_+_51435911 0.907 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr9_-_130829598 0.895 NM_197956
NAIF1
nuclear apoptosis inducing factor 1
chr17_+_15848422 0.890 ADORA2B
adenosine A2b receptor
chr11_+_111473099 0.886 NM_015191
SIK2
salt-inducible kinase 2
chr12_-_48298765 0.886 NM_000376
NM_001017535
NM_001017536
VDR


vitamin D (1,25- dihydroxyvitamin D3) receptor


chr5_-_139943829 0.885 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr15_-_72612247 0.879 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr14_-_94844881 0.876 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr15_-_52587851 0.875 NM_018728
MYO5C
myosin VC
chr19_+_797452 0.873 PTBP1
polypyrimidine tract binding protein 1
chr6_-_134497069 0.872 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr15_-_41408409 0.871 INO80
INO80 homolog (S. cerevisiae)
chr7_+_44836309 0.869 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr7_-_140624280 0.869 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr2_-_74734498 0.869 PCGF1
polycomb group ring finger 1
chr7_-_139477437 0.863 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr2_+_233734993 0.862 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr7_+_114055048 0.853 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr11_-_2182408 0.848 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough
chr19_-_41870001 0.842 NM_030578
B9D2
B9 protein domain 2
chr7_+_114055234 0.840 FOXP2
forkhead box P2
chr1_+_110026452 0.840 NM_153340
ATXN7L2
ataxin 7-like 2
chr10_+_71812356 0.840 NM_018649
H2AFY2
H2A histone family, member Y2
chr3_-_9290592 0.836 SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr20_+_44563310 0.832 NM_022104
PCIF1
PDX1 C-terminal inhibiting factor 1
chr1_-_161102367 0.829 DEDD
death effector domain containing
chr19_+_7911385 0.828 NM_001159944
EVI5L
ecotropic viral integration site 5-like
chr17_+_42634598 0.821 NM_001466
FZD2
frizzled family receptor 2
chr18_-_47814024 0.820 CXXC1
CXXC finger protein 1
chr19_+_797448 0.820 PTBP1
polypyrimidine tract binding protein 1
chrX_+_153059903 0.814 NM_001204526
NM_006280
SSR4

signal sequence receptor, delta

chr11_-_116693907 0.807 NM_000482
APOA4
apolipoprotein A-IV
chr7_+_39017608 0.807 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr1_+_145507556 0.805 NM_005105
RBM8A
RNA binding motif protein 8A
chr15_+_42131010 0.803 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr1_+_161719540 0.800 NM_007240
DUSP12
dual specificity phosphatase 12
chr1_+_97187174 0.796 NM_021190
PTBP2
polypyrimidine tract binding protein 2
chr2_+_189839132 0.796 COL3A1
collagen, type III, alpha 1
chr12_-_15114495 0.793 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr9_-_34522972 0.792 NM_198573
ENHO
energy homeostasis associated
chr17_+_78388944 0.791 NM_001164637
NM_001164638
NM_173627
ENDOV


endonuclease V


chr3_-_59035700 0.790 NM_198463
C3orf67
chromosome 3 open reading frame 67
chr22_-_36236264 0.788 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_+_203776930 0.788 NM_001104586
NM_024744
ALS2CR8

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

chr3_-_133748828 0.787 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chrX_+_106171328 0.787 CLDN2
claudin 2
chr16_-_29625037 0.785


chr6_-_88854989 0.785 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr6_-_26189303 0.781 NM_003539
HIST1H4D
histone cluster 1, H4d
chr1_+_180897572 0.778


chr20_-_5107185 0.778 NM_002592
PCNA
proliferating cell nuclear antigen
chr19_+_797390 0.778 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr11_-_66103874 0.777 NM_004292
RIN1
Ras and Rab interactor 1
chr11_+_1331048 0.775 LOC255512
uncharacterized LOC255512
chr13_+_93879011 0.774 NM_005708
GPC6
glypican 6
chr5_-_27038650 0.773 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr5_+_41925355 0.773 NM_012176
NM_033484
FBXO4

F-box protein 4

chr12_-_102591547 0.771 NM_002674
PMCH
pro-melanin-concentrating hormone
chr9_-_134955056 0.771 MED27
mediator complex subunit 27
chr7_+_114055171 0.769 FOXP2
forkhead box P2
chr18_-_47814005 0.767 CXXC1
CXXC finger protein 1
chr6_-_134496833 0.767 SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_106546736 0.765 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr16_+_56642477 0.764 NM_005953
MT2A
metallothionein 2A
chr13_-_37679800 0.764 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chr1_-_149899623 0.764 SF3B4
splicing factor 3b, subunit 4, 49kDa
chr2_+_39893021 0.762 NM_152390
TMEM178
transmembrane protein 178
chr12_-_6665220 0.760 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr1_-_153606567 0.755 NM_001024210
S100A13
S100 calcium binding protein A13
chr17_+_78010430 0.753 NM_001243342
NM_017950
CCDC40

coiled-coil domain containing 40

chr5_+_167956545 0.752


chr6_+_41020939 0.752 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr2_+_155555092 0.751 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr16_-_30621628 0.746 NM_138447
ZNF689
zinc finger protein 689
chr9_+_131902208 0.745 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr7_-_16505292 0.745 NM_015464
SOSTDC1
sclerostin domain containing 1
chr20_+_10199455 0.744 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr6_+_75994713 0.741 LOC100506804
uncharacterized LOC100506804
chr1_+_27648622 0.740 NM_032125
TMEM222
transmembrane protein 222
chr19_-_38746978 0.739 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr9_+_130026755 0.739 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr12_-_22697439 0.738 NM_014802
KIAA0528
KIAA0528
chr20_-_44600939 0.734 ZNF335
zinc finger protein 335
chr11_+_111749947 0.733 NM_022761
C11orf1
chromosome 11 open reading frame 1
chr10_-_90342947 0.732 NM_001031709
NM_018363
RNLS

renalase, FAD-dependent amine oxidase

chr2_-_190044330 0.732 NM_000393
COL5A2
collagen, type V, alpha 2
chr19_+_797444 0.731 PTBP1
polypyrimidine tract binding protein 1
chr4_+_75858205 0.731 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chr1_+_61547625 0.729 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr11_-_115375065 0.729 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr7_-_73184535 0.729 NM_001306
CLDN3
claudin 3
chr9_+_214816 0.727 DOCK8
dedicator of cytokinesis 8
chr19_+_1269244 0.725 NM_001280
CIRBP
cold inducible RNA binding protein
chr17_+_47865980 0.725 NM_001199155
NM_001199156
NM_001199157
NM_001199158
NM_007067
KAT7




K(lysine) acetyltransferase 7




chr1_-_220101781 0.725


chr5_+_180650709 0.724 TRIM41
tripartite motif containing 41
chr1_+_27023932 0.723 ARID1A
AT rich interactive domain 1A (SWI-like)
chr11_-_117186364 0.722 BACE1
beta-site APP-cleaving enzyme 1
chr22_-_33402648 0.721 NM_003490
NM_133633
SYN3

synapsin III

chr9_-_140115774 0.719 NM_031297
RNF208
ring finger protein 208
chr11_-_116968986 0.715 NM_025164
SIK3
SIK family kinase 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
37.30 1.09e-15 GO:0006334 nucleosome assembly
35.38 2.24e-15 GO:0031497 chromatin assembly
33.64 4.44e-15 GO:0034728 nucleosome organization
32.38 7.49e-15 GO:0065004 protein-DNA complex assembly
30.64 1.58e-14 GO:0071824 protein-DNA complex subunit organization
27.02 8.50e-14 GO:0006323 DNA packaging
25.42 1.92e-13 GO:0006333 chromatin assembly or disassembly
23.19 6.48e-13 GO:0071103 DNA conformation change
10.98 1.51e-09 GO:0034622 cellular macromolecular complex assembly
6.65 1.59e-08 GO:0071844 cellular component assembly at cellular level
8.24 6.84e-08 GO:0034621 cellular macromolecular complex subunit organization
8.01 4.72e-07 GO:0006325 chromatin organization
4.74 2.88e-06 GO:0022607 cellular component assembly
5.84 5.78e-06 GO:0065003 macromolecular complex assembly
6.16 1.09e-05 GO:0051276 chromosome organization
4.23 1.53e-05 GO:0044085 cellular component biogenesis
4.90 5.23e-05 GO:0043933 macromolecular complex subunit organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
57.19 6.63e-19 GO:0000786 nucleosome
36.12 4.11e-16 GO:0032993 protein-DNA complex
14.93 4.85e-11 GO:0000785 chromatin
7.83 1.52e-07 GO:0044427 chromosomal part
6.56 1.27e-06 GO:0005694 chromosome
2.30 1.04e-03 GO:0043228 non-membrane-bounded organelle
2.30 1.04e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.61 1.28e-02 GO:0044446 intracellular organelle part
1.58 1.71e-02 GO:0044422 organelle part
1.86 1.88e-02 GO:0032991 macromolecular complex

Nothing significant found in function category.