Contents IFN_6h_RNA_vs_IFN_24h_RNA



S5 G.1: Statistical overview

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SUMMARY


MA plots with GeneOntology extension:


Heat map based on fold change selection

S5 G.2: Differential expressed genes

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S5 G.3: Piano GO enrichment

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UP/DOWNIDNameDescriptionP-value
DOWNGO:0005840ribosome"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]9.999e-05
DOWNGO:0030529intracellular ribonucleoprotein complex"An intracellular macromolecular complex containing both protein and RNA molecules." [GOC:krc, GOC:vesicles]9.999e-05
DOWNGO:0003735structural constituent of ribosome"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]9.999e-05
DOWNGO:0003924GTPase activity"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]0.00059994
DOWNGO:0005525GTP binding"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]0.000149985
DOWNGO:0019899enzyme binding"Interacting selectively and non-covalently with any enzyme." [GOC:jl]0.022148
DOWNGO:0031012extracellular matrix"A structure lying external to one or more cells, which provides structural support for cells or tissues." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]9.999e-05
DOWNGO:0006364rRNA processing"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]0.000249975
DOWNGO:0015629actin cytoskeleton"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]0.042696
DOWNGO:0045296cadherin binding"Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]0.0040496
DOWNGO:0003779actin binding"Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]0.000649935
DOWNGO:0051015actin filament binding"Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]9.999e-05
UPGO:0004930G-protein coupled receptor activity"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]9.999e-05
UPGO:0007186G-protein coupled receptor signaling pathway"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor]9.999e-05
UPGO:0009897external side of plasma membrane"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]0.00544945
UPGO:0005887integral component of plasma membrane"The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]9.999e-05
UPGO:0006629lipid metabolic process"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]0.000899915
UPGO:0006811ion transport"The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]0.00104991
UPGO:0004871signal transducer activity"Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]0.00539945
UPGO:0035556intracellular signal transduction"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]0.000899915
UPGO:0018108peptidyl-tyrosine phosphorylation"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]9.999e-05
UPGO:0045893positive regulation of transcription, DNA-templated"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]0.000349965