| DOWN | GO:0005840 | ribosome | "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] | 9.999e-05 |
| DOWN | GO:0030529 | intracellular ribonucleoprotein complex | "An intracellular macromolecular complex containing both protein and RNA molecules." [GOC:krc, GOC:vesicles] | 9.999e-05 |
| DOWN | GO:0003735 | structural constituent of ribosome | "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] | 9.999e-05 |
| DOWN | GO:0003924 | GTPase activity | "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] | 0.00059994 |
| DOWN | GO:0005525 | GTP binding | "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] | 0.000149985 |
| DOWN | GO:0019899 | enzyme binding | "Interacting selectively and non-covalently with any enzyme." [GOC:jl] | 0.022148 |
| DOWN | GO:0031012 | extracellular matrix | "A structure lying external to one or more cells, which provides structural support for cells or tissues." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513] | 9.999e-05 |
| DOWN | GO:0006364 | rRNA processing | "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] | 0.000249975 |
| DOWN | GO:0015629 | actin cytoskeleton | "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] | 0.042696 |
| DOWN | GO:0045296 | cadherin binding | "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] | 0.0040496 |
| DOWN | GO:0003779 | actin binding | "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] | 0.000649935 |
| DOWN | GO:0051015 | actin filament binding | "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] | 9.999e-05 |
| UP | GO:0004930 | G-protein coupled receptor activity | "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] | 9.999e-05 |
| UP | GO:0007186 | G-protein coupled receptor signaling pathway | "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576PMID\:24568158, Wikipedia:G_protein-coupled_receptor] | 9.999e-05 |
| UP | GO:0009897 | external side of plasma membrane | "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] | 0.00544945 |
| UP | GO:0005887 | integral component of plasma membrane | "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] | 9.999e-05 |
| UP | GO:0006629 | lipid metabolic process | "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] | 0.000899915 |
| UP | GO:0006811 | ion transport | "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] | 0.00104991 |
| UP | GO:0004871 | signal transducer activity | "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] | 0.00539945 |
| UP | GO:0035556 | intracellular signal transduction | "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] | 0.000899915 |
| UP | GO:0018108 | peptidyl-tyrosine phosphorylation | "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] | 9.999e-05 |
| UP | GO:0045893 | positive regulation of transcription, DNA-templated | "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] | 0.000349965 |
