Contents Mock_6h_RNA_vs_IFN_6h_RNA



S5 B.1: Statistical overview

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SUMMARY


MA plots with GeneOntology extension:


Heat map based on fold change selection

S5 B.2: Differential expressed genes

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S5 B.3: Piano GO enrichment

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UP/DOWNIDNameDescriptionP-value
DOWNGO:0016310phosphorylation"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]0.0107991
DOWNGO:0016301kinase activity"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]0.00444955
DOWNGO:0006886intracellular protein transport"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]0.011649
DOWNGO:0005813centrosome"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]0.01179875
DOWNGO:0008017microtubule binding"Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]0.0178485
DOWNGO:0005794Golgi apparatus"A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]9.999e-05
DOWNGO:0005769early endosome"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]0.0041996
DOWNGO:0055085transmembrane transport"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other" [GOC:dph, GOC:jid]0.0029497
DOWNGO:0006468protein phosphorylation"The process of introducing a phosphate group on to a protein." [GOC:hb]0.021948
UPGO:0042612MHC class I protein complex"A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]9.999e-05
UPGO:0002474antigen processing and presentation of peptide antigen via MHC class I"The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]9.999e-05
UPGO:0019882antigen processing and presentation"The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:15771591, PMID:15928678]9.999e-05
UPGO:0002376immune system process"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]9.999e-05
UPGO:0003924GTPase activity"Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]9.999e-05
UPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling"Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling." [GOC:jl]0.000449955
UPGO:0005525GTP binding"Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]9.999e-05
UPGO:0003723RNA binding"Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]0.0477454
UPGO:0008233peptidase activity"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]0.00284975
UPGO:0051607defense response to virus"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]9.999e-05
UPGO:0006955immune response"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]9.999e-05