Contents RVFV_6h_RNA_vs_RVFV_24h_RNA



S5 I.1: Statistical overview

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SUMMARY


MA plots with GeneOntology extension:


Heat map based on fold change selection

S5 I.2: Differential expressed genes

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S5 I.3: Piano GO enrichment

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UP/DOWNIDNameDescriptionP-value
DOWNGO:0005747mitochondrial respiratory chain complex I"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]9.999e-05
DOWNGO:0003735structural constituent of ribosome"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]9.999e-05
DOWNGO:0005743mitochondrial inner membrane"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]9.999e-05
DOWNGO:0005840ribosome"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]9.999e-05
DOWNGO:0005198structural molecule activity"The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell." [GOC:mah, GOC:vw]0.00079992
DOWNGO:0005694chromosome"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]9.999e-05
DOWNGO:0030529intracellular ribonucleoprotein complex"An intracellular macromolecular complex containing both protein and RNA molecules." [GOC:krc, GOC:vesicles]9.999e-05
DOWNGO:0005874microtubule"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]9.999e-05
DOWNGO:0043209myelin sheath"An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao-593830697, Wikipedia:Myelin]9.999e-05
DOWNGO:0031012extracellular matrix"A structure lying external to one or more cells, which provides structural support for cells or tissues." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]9.999e-05
DOWNGO:0005819spindle"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]0.000249975
DOWNGO:0005200structural constituent of cytoskeleton"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]9.999e-05
DOWNGO:0000786nucleosome"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]9.999e-05
DOWNGO:0015031protein transport"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]9.999e-05
DOWNGO:0009055electron carrier activity"Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732]9.999e-05
UPGO:0006955immune response"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]9.999e-05
UPGO:0002376immune system process"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]9.999e-05
UPGO:0045087innate immune response"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]9.999e-05
UPGO:0000209protein polyubiquitination"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]9.999e-05
UPGO:0051607defense response to virus"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]9.999e-05
UPGO:0007623circadian rhythm"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]9.999e-05
UPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling"Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling." [GOC:jl]9.999e-05
UPGO:0042612MHC class I protein complex"A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]9.999e-05
UPGO:0002474antigen processing and presentation of peptide antigen via MHC class I"The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]9.999e-05
UPGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding"Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]9.999e-05
UPGO:0006366transcription from RNA polymerase II promoter"The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]9.999e-05
UPGO:0006357regulation of transcription from RNA polymerase II promoter"Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]9.999e-05
UPGO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]9.999e-05
UPGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH]9.999e-05
UPGO:0061630ubiquitin protein ligase activity"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]9.999e-05
UPGO:0001078transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding"Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]9.999e-05
UPGO:0071222cellular response to lipopolysaccharide"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]9.999e-05
UPGO:0019882antigen processing and presentation"The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:15771591, PMID:15928678]9.999e-05
UPGO:0009897external side of plasma membrane"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]0.026597
UPGO:0004842ubiquitin-protein transferase activity"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]9.999e-05
UPGO:0042981regulation of apoptotic process"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]0.000249975