PZP
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PZP | CPAMD6 | pregnancy-zone protein | NM_002864 |  |
NONE |  |
NONE |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes the Homo sapiens pregnancy-zone protein (PZP). It is able to inhibit all four classes of proteinases by a unique `trapping' mechanism. This protein has a peptide stretch, called the `bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. available.
It is highly expressed in bat cells and looks to be highly expressed in human cells, but post-transcriptionally completely degraded. Several cleavage sites are visible where some RNA may still be protected by the endoribonuclease.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 472 | 655 | 1026 | 664 | 551 | 1903 | 939 | 1106 | 789 |
Read_Max |  | R. aegyptiacus | Transcriptome | 845 | 899 | 748 | 765 | 564 | 976 | 550 | 869 | 870 |
Read_Max |  | R. aegyptiacus | Genome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | H. sapiens | Genome | 599.72 | 300.84 | 1179.48 | 7.84 | 556.25 | 2284.13 | 1125.58 | 1391.87 | 792.59 |
DESeq | | R. aegyptiacus | Transcriptome | 8080.63 | 8325.42 | 9245.59 | 7925.19 | 6869.4 | 8653.49 | 6872.33 | 7489.75 | 7309.19 |
DESeq | | R. aegyptiacus | Genome | NA | NA | NA | NA | NA | NA | NA | NA | NA |