ANKRD1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| ANKRD1 | C193, CARP, HA1A2,C-193, ALRP, CVARP, MCARP | ankyrin repeat domain 1 (cardiac muscle) | NM_014391 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Homo sapiens ankyrin repeat domain 1 (cardiac muscle) (ANKRD1), mRNA. The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
The ankyrin repeat domain 1 (ANKRD1) gene is differentially expressed in human and bat cell lines infected with EBOV. Whereas in human cells 23 h p.i.\ it is 18.6X up-regulated (read\_max: 1\,670), expression is slightly down-regulated (2X) in bat cells. For MARV it is the other way around: ANKRD1 is slightly down-regulated (0.8X) in humans and slightly up-regulated in bat cells. The protein expressed by the gene is, amongst other functions, involved in transcriptional regulation and in communication between the sarcoplasm and the nucleus [Almodovar-Garcia et al., Mol Cell Biol, 2014, 34:1500-1511]. Differentially induced expression has also been shown upon human papillomavirus infection [Kaczkowski et al., Sci Rep, 2012, 2:515].
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 111 | 83 | 15 | 166 | 90 | 1670 | 246 | 134 | 95 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 1124 | 655 | 404 | 960 | 552 | 232 | 687 | 1028 | 1335 |
DESeq | | H. sapiens | Genome | 804.71 | 453.82 | 56.6 | 1169.06 | 468.45 | 9428.27 | 1316.81 | 685.24 | 771.93 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 5428.77 | 4341.64 | 3249.14 | 6155.97 | 4693.34 | 2322.32 | 6091.59 | 5122.43 | 6507.06 |