HDAC9

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HDAC9 HDAC9, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR,KIAA0744 histone deacetylase 9 pdf NONE

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Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis.

HDAC9 is poorly expressed in all examined samples except Ebola infected cells at 7 h post infection, where a strong upergulation can be seen.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome13 12 25 20 10 167 20 17 13
Read_Max
batR. aegyptiacusTranscriptome 13 13 5 8 4 6 8 12 16
Read_Max
bat_genomeR. aegyptiacusGenome 10 9 4 8 4 4 7 9 12
DESeq
humanH. sapiensGenome 63.92 42.81 18.87 63.74 48.96 2618.37 58.9 44.16 157.58
DESeq
batR. aegyptiacusTranscriptome 46.37 35.49 16.88 39.46 20.71 18.96 19.91 40.66 51.73
DESeq
bat_genomeR. aegyptiacusGenome 90.24 85.79 47.98 85.91 44.65 40.47 86.59 81.67 101.03

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 63.92 63.74 58.9 -0.0 -0.12 -0.11
7h 42.81 48.96 44.16 0.19 0.04 -0.15
23h 18.87 2618.37 157.58 7.12 3.06 -4.05

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 63.92 42.81 18.87 -0.58 -1.76 -1.18
Ebov 63.74 48.96 2618.37 -0.38 5.36 5.74
Marv 58.9 44.16 157.58 -0.42 1.42 1.84

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 46.37 39.46 19.91 -0.23 -1.22 -0.99
7h 35.49 20.71 40.66 -0.78 0.2 0.97
23h 16.88 18.96 51.73 0.17 1.62 1.45

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 46.37 35.49 16.88 -0.39 -1.46 -1.07
Ebov 39.46 20.71 18.96 -0.93 -1.06 -0.13
Marv 19.91 40.66 51.73 1.03 1.38 0.35