HDAC9

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
HDAC9	HDAC9, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR,KIAA0744	histone deacetylase 9		pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis.

HDAC9 is poorly expressed in all examined samples except Ebola infected cells at 7 h post infection, where a strong upergulation can be seen.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	13	12	25	20	10	167	20	17	13
Read_Max	R. aegyptiacus	Transcriptome	13	13	5	8	4	6	8	12	16
Read_Max	R. aegyptiacus	Genome	10	9	4	8	4	4	7	9	12
DESeq	H. sapiens	Genome	63.92	42.81	18.87	63.74	48.96	2618.37	58.9	44.16	157.58
DESeq	R. aegyptiacus	Transcriptome	46.37	35.49	16.88	39.46	20.71	18.96	19.91	40.66	51.73
DESeq	R. aegyptiacus	Genome	90.24	85.79	47.98	85.91	44.65	40.47	86.59	81.67	101.03

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	63.92	63.74	58.9	-0.0	-0.12	-0.11
7h	42.81	48.96	44.16	0.19	0.04	-0.15
23h	18.87	2618.37	157.58	7.12	3.06	-4.05

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	63.92	42.81	18.87	-0.58	-1.76	-1.18
Ebov	63.74	48.96	2618.37	-0.38	5.36	5.74
Marv	58.9	44.16	157.58	-0.42	1.42	1.84

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	46.37	39.46	19.91	-0.23	-1.22	-0.99
7h	35.49	20.71	40.66	-0.78	0.2	0.97
23h	16.88	18.96	51.73	0.17	1.62	1.45

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	46.37	35.49	16.88	-0.39	-1.46	-1.07
Ebov	39.46	20.71	18.96	-0.93	-1.06	-0.13
Marv	19.91	40.66	51.73	1.03	1.38	0.35

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material