IL8

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IL8 hg.goi.00009 pdf NONE

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Description

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.

The gene is rather lowly expressed. In the Ebola infected human cells cells 23 h after infection the expression is three times as large.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome23 15 3 26 18 171 51 30 23
Read_Max
batR. aegyptiacusTranscriptome 13 3 5 3 7 7 6 16 5
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 92.33 64.23 10.93 154.99 64.41 837.93 181.7 86.53 123.87
DESeq
batR. aegyptiacusTranscriptome 28.72 7.35 11.99 7.41 19.62 16.4 12.12 20.0 10.62
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 92.33 154.99 181.7 0.75 0.98 0.23
7h 64.23 64.41 86.53 0.0 0.43 0.43
23h 10.93 837.93 123.87 6.26 3.5 -2.76

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 92.33 64.23 10.93 -0.52 -3.08 -2.55
Ebov 154.99 64.41 837.93 -1.27 2.43 3.7
Marv 181.7 86.53 123.87 -1.07 -0.55 0.52

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 28.72 7.41 12.12 -1.95 -1.24 0.71
7h 7.35 19.62 20.0 1.42 1.44 0.03
23h 11.99 16.4 10.62 0.45 -0.18 -0.63

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 28.72 7.35 11.99 -1.97 -1.26 0.71
Ebov 7.41 19.62 16.4 1.4 1.15 -0.26
Marv 12.12 20.0 10.62 0.72 -0.19 -0.91