MYCN

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MYCN NMYC, ODED, MODED, N-myc, bHLHe37,bHLHe37, MYCNOT v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog NM_005378 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The transcriptional regulator MYCN has to dimerize, preferentially with the Max protein, to bind to DNA by a basic helix-loop-helix motif [Ma et al., Oncogene, 1993, 8:1093-1098]. N-myc has been shown to both up- and down-regulate many target genes, in addition, this factor modulates the expression of several classes of non-coding RNAs, in particular microRNAs [Buechner and Einvik, Mol Cancer Res, 2012, 10:1243-1253]. N-myc mRNA was strongly down-regulated (20X) in human cells infected with EBOV, whereas in MARV-infected cells, only slight down-regulation was observed (3X). This gene is not part of the bat transcriptome assembly. Due to the very strong down-regulation of n-myc, it seems to be very important for an EBOV infection to deplete this factor from infected cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome238 275 373 195 340 15 218 322 102
Read_Max
batR. aegyptiacusTranscriptome 1 1 1 1 1 1 2 1 2
Read_Max
bat_genomeR. aegyptiacusGenome 1 0 1 1 0 0 2 0 0
DESeq
humanH. sapiensGenome 2852.55 3707.22 4918.46 2654.23 3531.65 69.43 2369.45 3366.27 1338.44
DESeq
batR. aegyptiacusTranscriptome 1.0 1.0 2.22 1.0 1.0 1.0 3.22 1.0 2.75
DESeq
bat_genomeR. aegyptiacusGenome 2.58 0.0 1.12 0.99 0.0 0.0 2.25 0.0 0.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2852.55 2654.23 2369.45 -0.1 -0.27 -0.16
7h 3707.22 3531.65 3366.27 -0.07 -0.14 -0.07
23h 4918.46 69.43 1338.44 -6.15 -1.88 4.27

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2852.55 3707.22 4918.46 0.38 0.79 0.41
Ebov 2654.23 3531.65 69.43 0.41 -5.26 -5.67
Marv 2369.45 3366.27 1338.44 0.51 -0.82 -1.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 3.22 0.0 1.69 1.69
7h 1.0 1.0 1.0 0.0 0.0 0.0
23h 2.22 1.0 2.75 -1.15 0.31 1.46

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 2.22 0.0 1.15 1.15
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 3.22 1.0 2.75 -1.69 -0.23 1.46