FOS

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
FOS	FOS, C-FOS, p55,c-fos, AP-1	FBJ murine osteosarcoma viral oncogene homolog	NM_005252	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.

The FOS gene is only expressed in human cells cells 23 h after infection with Ebola virus.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	4	5	15	7	6	383	12	18	14
Read_Max	R. aegyptiacus	Transcriptome	7	8	20	9	13	15	10	11	16
Read_Max	R. aegyptiacus	Genome	10	9	14	8	12	8	9	14	14
DESeq	H. sapiens	Genome	18.25	33.64	51.63	42.06	36.77	2430.19	66.79	80.94	70.59
DESeq	R. aegyptiacus	Transcriptome	32.09	41.85	60.86	31.22	49.18	81.84	33.26	44.79	75.35
DESeq	R. aegyptiacus	Genome	41.25	36.51	53.56	53.32	62.5	107.04	50.6	65.02	101.03

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	18.25	42.06	66.79	1.2	1.87	0.67
7h	33.64	36.77	80.94	0.13	1.27	1.14
23h	51.63	2430.19	70.59	5.56	0.45	-5.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	18.25	33.64	51.63	0.88	1.5	0.62
Ebov	42.06	36.77	2430.19	-0.19	5.85	6.05
Marv	66.79	80.94	70.59	0.28	0.08	-0.2

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	32.09	31.22	33.26	-0.04	0.05	0.09
7h	41.85	49.18	44.79	0.23	0.1	-0.13
23h	60.86	81.84	75.35	0.43	0.31	-0.12

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	32.09	41.85	60.86	0.38	0.92	0.54
Ebov	31.22	49.18	81.84	0.66	1.39	0.73
Marv	33.26	44.79	75.35	0.43	1.18	0.75

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

FOS