FOS

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FOS FOS, C-FOS, p55,c-fos, AP-1 FBJ murine osteosarcoma viral oncogene homolog NM_005252 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.

The FOS gene is only expressed in human cells cells 23 h after infection with Ebola virus.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 5 15 7 6 383 12 18 14
Read_Max
batR. aegyptiacusTranscriptome 7 8 20 9 13 15 10 11 16
Read_Max
bat_genomeR. aegyptiacusGenome 10 9 14 8 12 8 9 14 14
DESeq
humanH. sapiensGenome 18.25 33.64 51.63 42.06 36.77 2430.19 66.79 80.94 70.59
DESeq
batR. aegyptiacusTranscriptome 32.09 41.85 60.86 31.22 49.18 81.84 33.26 44.79 75.35
DESeq
bat_genomeR. aegyptiacusGenome 41.25 36.51 53.56 53.32 62.5 107.04 50.6 65.02 101.03

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 18.25 42.06 66.79 1.2 1.87 0.67
7h 33.64 36.77 80.94 0.13 1.27 1.14
23h 51.63 2430.19 70.59 5.56 0.45 -5.11

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 18.25 33.64 51.63 0.88 1.5 0.62
Ebov 42.06 36.77 2430.19 -0.19 5.85 6.05
Marv 66.79 80.94 70.59 0.28 0.08 -0.2

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 32.09 31.22 33.26 -0.04 0.05 0.09
7h 41.85 49.18 44.79 0.23 0.1 -0.13
23h 60.86 81.84 75.35 0.43 0.31 -0.12

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 32.09 41.85 60.86 0.38 0.92 0.54
Ebov 31.22 49.18 81.84 0.66 1.39 0.73
Marv 33.26 44.79 75.35 0.43 1.18 0.75