ZEB2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ZEB2 SIP1,ZFHX1B, HSPC082, SMADIP1,KIAA0569, SIP-1, SIP1 zinc finger E-box binding homeobox 2 NM_014795 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.

This gene is higher expressed in human cells cells 23 h after Ebola infection but generally lowly expressed. In bat cells the gene is higher expressed in general.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 4 3 4 2 45 2 3 11
Read_Max
batR. aegyptiacusTranscriptome 144 118 85 94 75 144 104 109 143
Read_Max
bat_genomeR. aegyptiacusGenome 157 92 72 119 68 87 88 132 152
DESeq
humanH. sapiensGenome 11.15 22.42 14.9 29.52 9.13 552.37 22.05 12.19 83.64
DESeq
batR. aegyptiacusTranscriptome 1903.08 1537.72 1117.48 1503.61 1318.39 2491.66 1639.57 1216.35 1290.32
DESeq
bat_genomeR. aegyptiacusGenome 2447.54 1882.87 1519.69 2062.85 1824.88 3472.39 2241.19 1669.94 1751.77

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 11.15 29.52 22.05 1.4 0.98 -0.42
7h 22.42 9.13 12.19 -1.3 -0.88 0.42
23h 14.9 552.37 83.64 5.21 2.49 -2.72

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 11.15 22.42 14.9 1.01 0.42 -0.59
Ebov 29.52 9.13 552.37 -1.69 4.23 5.92
Marv 22.05 12.19 83.64 -0.86 1.92 2.78

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1903.08 1503.61 1639.57 -0.34 -0.22 0.12
7h 1537.72 1318.39 1216.35 -0.22 -0.34 -0.12
23h 1117.48 2491.66 1290.32 1.16 0.21 -0.95

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1903.08 1537.72 1117.48 -0.31 -0.77 -0.46
Ebov 1503.61 1318.39 2491.66 -0.19 0.73 0.92
Marv 1639.57 1216.35 1290.32 -0.43 -0.35 0.09