AREG

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
AREG SDGF amphiregulin pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.

Amphiregulin (AREG) belongs together with e.g. EGF, epiregulin and different neuregulins (1-4) to the epidermal growth factor receptor (EGFR) ligands. EGFRs transmit signals via \update mitogen-activated protein cascade to the nucleus [Roberts and Der, Oncogene, 2007, 26:3291-3310]. It was 20.3X up-regulated in human cells subsequent to EBOV infection. In bat cells, no expression of this gene was observed. Also during HCV infection AREG is up-regulated and seems to be essential for efficient HCV assembly and release [Pei et al., J Gen Virol, 2011, 92:2237-2248; Wilson et al., Growth Factors, 2012, 30:107-116].

Upregulated in human cells after 23 h of Ebola virus infection but no homolog found in bat cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome30 23 16 32 27 549 49 25 46
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 0 0 0 0 0 0 0 0 0
DESeq
humanH. sapiensGenome 3.03 1.0 1.0 14.69 2.63 106.27 9.77 5.8 3.17
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3.03 14.69 9.77 2.28 1.69 -0.59
7h 1.0 2.63 5.8 1.4 2.54 1.14
23h 1.0 106.27 3.17 6.73 1.66 -5.07

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3.03 1.0 1.0 -1.6 -1.6 0.0
Ebov 14.69 2.63 106.27 -2.48 2.85 5.34
Marv 9.77 5.8 3.17 -0.75 -1.62 -0.87

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA