AREG
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| AREG | SDGF | amphiregulin |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.
Amphiregulin (AREG) belongs together with e.g. EGF, epiregulin and different neuregulins (1-4) to the epidermal growth factor receptor (EGFR) ligands. EGFRs transmit signals via \update mitogen-activated protein cascade to the nucleus [Roberts and Der, Oncogene, 2007, 26:3291-3310]. It was 20.3X up-regulated in human cells subsequent to EBOV infection. In bat cells, no expression of this gene was observed. Also during HCV infection AREG is up-regulated and seems to be essential for efficient HCV assembly and release [Pei et al., J Gen Virol, 2011, 92:2237-2248; Wilson et al., Growth Factors, 2012, 30:107-116].
Upregulated in human cells after 23 h of Ebola virus infection but no homolog found in bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 30 | 23 | 16 | 32 | 27 | 549 | 49 | 25 | 46 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DESeq | | H. sapiens | Genome | 3.03 | 1.0 | 1.0 | 14.69 | 2.63 | 106.27 | 9.77 | 5.8 | 3.17 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |