GDNF

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GDNF ATF1, ATF2, HFB1-GDNF glial cell derived neurotrophic factor NM_000514 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.

GDNF (as well as GDNF-AS1) seems to be very low expressed in human cells and moderately expressed in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2 0 1 2 0 10 2 2 2
Read_Max
batR. aegyptiacusTranscriptome 66 68 55 44 43 88 39 68 64
Read_Max
bat_genomeR. aegyptiacusGenome 180 119 111 126 78 67 91 182 159
DESeq
humanH. sapiensGenome 10.13 1.0 1.99 5.56 1.0 62.85 13.28 14.59 7.52
DESeq
batR. aegyptiacusTranscriptome 255.56 224.29 261.19 185.96 204.69 407.77 151.17 209.2 242.42
DESeq
bat_genomeR. aegyptiacusGenome 1619.09 1473.99 1938.11 1568.12 1625.09 2356.26 1475.39 1522.46 1608.78

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10.13 5.56 13.28 -0.87 0.39 1.26
7h 1.0 1.0 14.59 0.0 3.87 3.87
23h 1.99 62.85 7.52 4.98 1.92 -3.06

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10.13 1.0 1.99 -3.34 -2.35 0.99
Ebov 5.56 1.0 62.85 -2.48 3.5 5.97
Marv 13.28 14.59 7.52 0.14 -0.82 -0.96

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 255.56 185.96 151.17 -0.46 -0.76 -0.3
7h 224.29 204.69 209.2 -0.13 -0.1 0.03
23h 261.19 407.77 242.42 0.64 -0.11 -0.75

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 255.56 224.29 261.19 -0.19 0.03 0.22
Ebov 185.96 204.69 407.77 0.14 1.13 0.99
Marv 151.17 209.2 242.42 0.47 0.68 0.21