ATF3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ATF3 Activating Transcription Factor 3 activating transcription factor 3 NM_001674 pdf

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Description

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.

The gene ATF3 is significantly higher expressed in bat cells 23 h after Ebola virus infection compared to rest. In human cells the 23 h Ebola dataset is the only one showing expression of the 3'UTR, which may have regulatory function.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome29 19 52 19 46 1401 35 45 67
Read_Max
batR. aegyptiacusTranscriptome 9 13 46 25 31 127 12 28 51
Read_Max
bat_genomeR. aegyptiacusGenome 16 26 36 14 22 74 8 33 58
DESeq
humanH. sapiensGenome 162.35 146.84 222.4 177.81 212.37 10458.63 257.14 238.41 528.36
DESeq
batR. aegyptiacusTranscriptome 29.56 35.49 212.33 100.81 101.75 516.84 46.61 102.62 191.69
DESeq
bat_genomeR. aegyptiacusGenome 94.53 209.0 397.22 124.42 254.48 1117.43 105.71 233.13 494.02

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 162.35 177.81 257.14 0.13 0.66 0.53
7h 146.84 212.37 238.41 0.53 0.7 0.17
23h 222.4 10458.63 528.36 5.56 1.25 -4.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 162.35 146.84 222.4 -0.14 0.45 0.6
Ebov 177.81 212.37 10458.63 0.26 5.88 5.62
Marv 257.14 238.41 528.36 -0.11 1.04 1.15

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 29.56 100.81 46.61 1.77 0.66 -1.11
7h 35.49 101.75 102.62 1.52 1.53 0.01
23h 212.33 516.84 191.69 1.28 -0.15 -1.43

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 29.56 35.49 212.33 0.26 2.84 2.58
Ebov 100.81 101.75 516.84 0.01 2.36 2.34
Marv 46.61 102.62 191.69 1.14 2.04 0.9