GALNT6

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
GALNT6	GalNAc-T6	polypeptide N-acetylgalactosaminyltransferase 6	NM_007210	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6), mRNA. This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.

For this gene we observed very low expression in human cells and slightly better expression in bat cells with some expression variations.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	2	2	2	2	3	2	2	3	7
Read_Max	R. aegyptiacus	Transcriptome	32	35	27	27	19	32	23	30	34
Read_Max	R. aegyptiacus	Genome	36	30	24	31	16	19	20	35	40
DESeq	H. sapiens	Genome	4.04	8.14	8.94	8.98	5.06	2.32	5.39	10.59	74.94
DESeq	R. aegyptiacus	Transcriptome	263.12	319.6	136.59	239.99	217.83	310.25	285.78	238.12	294.03
DESeq	R. aegyptiacus	Genome	414.23	314.88	170.71	486.83	359.4	593.96	453.19	308.46	440.08

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4.04	8.98	5.39	1.15	0.42	-0.74
7h	8.14	5.06	10.59	-0.69	0.38	1.07
23h	8.94	2.32	74.94	-1.95	3.07	5.01

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4.04	8.14	8.94	1.01	1.15	0.14
Ebov	8.98	5.06	2.32	-0.83	-1.95	-1.13
Marv	5.39	10.59	74.94	0.97	3.8	2.82

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	263.12	239.99	285.78	-0.13	0.12	0.25
7h	319.6	217.83	238.12	-0.55	-0.42	0.13
23h	136.59	310.25	294.03	1.18	1.11	-0.08

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	263.12	319.6	136.59	0.28	-0.95	-1.23
Ebov	239.99	217.83	310.25	-0.14	0.37	0.51
Marv	285.78	238.12	294.03	-0.26	0.04	0.3

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material