GALNT6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GALNT6 GalNAc-T6 polypeptide N-acetylgalactosaminyltransferase 6 NM_007210 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6), mRNA. This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.

For this gene we observed very low expression in human cells and slightly better expression in bat cells with some expression variations.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2 2 2 2 3 2 2 3 7
Read_Max
batR. aegyptiacusTranscriptome 32 35 27 27 19 32 23 30 34
Read_Max
bat_genomeR. aegyptiacusGenome 36 30 24 31 16 19 20 35 40
DESeq
humanH. sapiensGenome 4.04 8.14 8.94 8.98 5.06 2.32 5.39 10.59 74.94
DESeq
batR. aegyptiacusTranscriptome 263.12 319.6 136.59 239.99 217.83 310.25 285.78 238.12 294.03
DESeq
bat_genomeR. aegyptiacusGenome 414.23 314.88 170.71 486.83 359.4 593.96 453.19 308.46 440.08

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4.04 8.98 5.39 1.15 0.42 -0.74
7h 8.14 5.06 10.59 -0.69 0.38 1.07
23h 8.94 2.32 74.94 -1.95 3.07 5.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4.04 8.14 8.94 1.01 1.15 0.14
Ebov 8.98 5.06 2.32 -0.83 -1.95 -1.13
Marv 5.39 10.59 74.94 0.97 3.8 2.82

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 263.12 239.99 285.78 -0.13 0.12 0.25
7h 319.6 217.83 238.12 -0.55 -0.42 0.13
23h 136.59 310.25 294.03 1.18 1.11 -0.08

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 263.12 319.6 136.59 0.28 -0.95 -1.23
Ebov 239.99 217.83 310.25 -0.14 0.37 0.51
Marv 285.78 238.12 294.03 -0.26 0.04 0.3