TMEM88

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TMEM88	MGC71744, FLJ20025	transmembrane protein 88	NM_203411	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

This gene is only expressed at Ebola infected cells after 23 h in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	3	1	3	2	2	23	3	4	4
Read_Max	R. aegyptiacus	Transcriptome	1	NA	6	5	2	7	2	4	1
Read_Max	R. aegyptiacus	Genome	2	5	5	2	2	5	3	5	2
DESeq	H. sapiens	Genome	8.1	2.02	10.93	6.7	2.63	87.85	7.14	8.99	9.7
DESeq	R. aegyptiacus	Transcriptome	2.68	1.0	10.77	9.24	3.19	13.83	3.22	5.96	1.87
DESeq	R. aegyptiacus	Genome	3.44	10.04	18.97	1.97	5.58	16.97	9.0	9.52	5.14

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8.1	6.7	7.14	-0.27	-0.18	0.09
7h	2.02	2.63	8.99	0.38	2.15	1.77
23h	10.93	87.85	9.7	3.01	-0.17	-3.18

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8.1	2.02	10.93	-2.0	0.43	2.44
Ebov	6.7	2.63	87.85	-1.35	3.71	5.06
Marv	7.14	8.99	9.7	0.33	0.44	0.11

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2.68	9.24	3.22	1.79	0.26	-1.52
7h	1.0	3.19	5.96	1.67	2.58	0.9
23h	10.77	13.83	1.87	0.36	-2.53	-2.89

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2.68	1.0	10.77	-1.42	2.01	3.43
Ebov	9.24	3.19	13.83	-1.53	0.58	2.12
Marv	3.22	5.96	1.87	0.89	-0.78	-1.67

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material