P2RY6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
P2RY6 G-Coupled Nucleotide Receptor,P2Y6 pyrimidinergic receptor P2Y, G-protein coupled, 6 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

The gene is low expressed in human cells, and shows no expression in bat cells throughout datasets. Reads terminate $>6000$\,nt after annotated 3'UTR end.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome7 11 7 10 7 3 17 21 17
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 7 4 4 6 4 2 4 5 4
DESeq
humanH. sapiensGenome 65.95 81.57 53.62 87.69 81.48 6.26 138.72 190.45 255.44
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 31.8 23.73 32.36 41.47 46.88 19.58 34.86 24.58 20.55

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 65.95 87.69 138.72 0.41 1.07 0.66
7h 81.57 81.48 190.45 -0.0 1.22 1.22
23h 53.62 6.26 255.44 -3.1 2.25 5.35

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 65.95 81.57 53.62 0.31 -0.3 -0.61
Ebov 87.69 81.48 6.26 -0.11 -3.81 -3.7
Marv 138.72 190.45 255.44 0.46 0.88 0.42

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA