DUSP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DUSP1 CL100, HVH1, MKP-1, PTPN10,HVH1, CL100 dual specificity phosphatase 1 NM_004417 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

In human cells it is highly upregulated after 23 h of infection and also upregulated in bat cells after 23 h of infection with Marburg virus and Ebola virus.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome62 62 40 69 59 1493 89 151 131
Read_Max
batR. aegyptiacusTranscriptome 144 153 132 119 126 408 118 178 260
Read_Max
bat_genomeR. aegyptiacusGenome 220 136 189 237 112 290 112 272 390
DESeq
humanH. sapiensGenome 448.52 306.96 208.5 507.46 355.45 8395.27 583.46 676.45 932.86
DESeq
batR. aegyptiacusTranscriptome 718.48 815.2 814.54 624.57 774.13 2124.67 770.79 818.12 1141.62
DESeq
bat_genomeR. aegyptiacusGenome 1191.11 979.31 1305.46 1431.85 1257.88 3434.53 1287.59 1307.57 1879.34

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 448.52 507.46 583.46 0.18 0.38 0.2
7h 306.96 355.45 676.45 0.21 1.14 0.93
23h 208.5 8395.27 932.86 5.33 2.16 -3.17

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 448.52 306.96 208.5 -0.55 -1.11 -0.56
Ebov 507.46 355.45 8395.27 -0.51 4.05 4.56
Marv 583.46 676.45 932.86 0.21 0.68 0.46

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 718.48 624.57 770.79 -0.2 0.1 0.3
7h 815.2 774.13 818.12 -0.07 0.01 0.08
23h 814.54 2124.67 1141.62 1.38 0.49 -0.9

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 718.48 815.2 814.54 0.18 0.18 -0.0
Ebov 624.57 774.13 2124.67 0.31 1.77 1.46
Marv 770.79 818.12 1141.62 0.09 0.57 0.48