DUSP8

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DUSP8 C11orf81, DUS8_HUMAN, NM_004420, NP_004411, Q13202, Q86SS8, VH5,HVH-5, HB5, FLJ42958 dual specificity phosphatase 8 NM_004420 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2

An interesting gene. Seems to be not differentially expressed in bat cells, but has a very high foldchange in Ebola infected cells in human cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome31 25 13 30 26 626 44 29 26
Read_Max
batR. aegyptiacusTranscriptome 48 53 35 48 42 72 24 42 58
Read_Max
bat_genomeR. aegyptiacusGenome 54 43 26 37 27 38 23 57 69
DESeq
humanH. sapiensGenome 429.24 298.8 223.39 396.82 282.28 9033.49 572.94 427.85 538.15
DESeq
batR. aegyptiacusTranscriptome 184.99 246.98 291.73 229.0 244.11 474.49 167.86 263.73 368.38
DESeq
bat_genomeR. aegyptiacusGenome 332.58 451.78 548.96 386.11 394.0 757.14 281.13 454.36 595.05

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 429.24 396.82 572.94 -0.11 0.42 0.53
7h 298.8 282.28 427.85 -0.08 0.52 0.6
23h 223.39 9033.49 538.15 5.34 1.27 -4.07

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 429.24 298.8 223.39 -0.52 -0.94 -0.42
Ebov 396.82 282.28 9033.49 -0.49 4.51 5.0
Marv 572.94 427.85 538.15 -0.42 -0.09 0.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 184.99 229.0 167.86 0.31 -0.14 -0.45
7h 246.98 244.11 263.73 -0.02 0.09 0.11
23h 291.73 474.49 368.38 0.7 0.34 -0.37

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 184.99 246.98 291.73 0.42 0.66 0.24
Ebov 229.0 244.11 474.49 0.09 1.05 0.96
Marv 167.86 263.73 368.38 0.65 1.13 0.48