DUSP8

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DUSP8	C11orf81, DUS8_HUMAN, NM_004420, NP_004411, Q13202, Q86SS8, VH5,HVH-5, HB5, FLJ42958	dual specificity phosphatase 8	NM_004420	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2

An interesting gene. Seems to be not differentially expressed in bat cells, but has a very high foldchange in Ebola infected cells in human cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	31	25	13	30	26	626	44	29	26
Read_Max	R. aegyptiacus	Transcriptome	48	53	35	48	42	72	24	42	58
Read_Max	R. aegyptiacus	Genome	54	43	26	37	27	38	23	57	69
DESeq	H. sapiens	Genome	429.24	298.8	223.39	396.82	282.28	9033.49	572.94	427.85	538.15
DESeq	R. aegyptiacus	Transcriptome	184.99	246.98	291.73	229.0	244.11	474.49	167.86	263.73	368.38
DESeq	R. aegyptiacus	Genome	332.58	451.78	548.96	386.11	394.0	757.14	281.13	454.36	595.05

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	429.24	396.82	572.94	-0.11	0.42	0.53
7h	298.8	282.28	427.85	-0.08	0.52	0.6
23h	223.39	9033.49	538.15	5.34	1.27	-4.07

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	429.24	298.8	223.39	-0.52	-0.94	-0.42
Ebov	396.82	282.28	9033.49	-0.49	4.51	5.0
Marv	572.94	427.85	538.15	-0.42	-0.09	0.33

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	184.99	229.0	167.86	0.31	-0.14	-0.45
7h	246.98	244.11	263.73	-0.02	0.09	0.11
23h	291.73	474.49	368.38	0.7	0.34	-0.37

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	184.99	246.98	291.73	0.42	0.66	0.24
Ebov	229.0	244.11	474.49	0.09	1.05	0.96
Marv	167.86	263.73	368.38	0.65	1.13	0.48

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material