VGF

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VGF SCG7, SgVII VGF nerve growth factor inducible NM_003378 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.

It is weakly expressed in human cells after 23 h of Ebola virus infection and constantly but low as well in bat cells. There seems to be an expressed location upstream of the gene in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2 0 0 0 2 16 2 0 4
Read_Max
batR. aegyptiacusTranscriptome 6 8 16 5 5 11 7 7 12
Read_Max
bat_genomeR. aegyptiacusGenome 8 8 9 9 6 7 4 10 14
DESeq
humanH. sapiensGenome 5.06 1.0 1.0 1.0 2.63 57.58 3.63 1.0 7.52
DESeq
batR. aegyptiacusTranscriptome 40.49 36.4 82.84 27.55 37.14 47.19 26.59 28.26 50.86
DESeq
bat_genomeR. aegyptiacusGenome 48.13 41.07 82.57 49.37 53.57 50.91 25.86 42.82 61.65

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5.06 1.0 3.63 -2.34 -0.48 1.86
7h 1.0 2.63 1.0 1.4 0.0 -1.4
23h 1.0 57.58 7.52 5.85 2.91 -2.94

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5.06 1.0 1.0 -2.34 -2.34 0.0
Ebov 1.0 2.63 57.58 1.4 5.85 4.45
Marv 3.63 1.0 7.52 -1.86 1.05 2.91

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 40.49 27.55 26.59 -0.56 -0.61 -0.05
7h 36.4 37.14 28.26 0.03 -0.37 -0.39
23h 82.84 47.19 50.86 -0.81 -0.7 0.11

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 40.49 36.4 82.84 -0.15 1.03 1.19
Ebov 27.55 37.14 47.19 0.43 0.78 0.35
Marv 26.59 28.26 50.86 0.09 0.94 0.85