GPX2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GPX2 GPRP-2, GSHPx-G,GSHPX-GI glutathione peroxidase 2 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described.

The gene GPX2 is not expressed in bat cells but upregulated in human cells 23 h after Marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome30 26 34 25 31 19 40 63 235
Read_Max
batR. aegyptiacusTranscriptome 1 2 0 4 2 4 1 1 2
Read_Max
bat_genomeR. aegyptiacusGenome 5 4 2 3 2 2 2 6 5
DESeq
humanH. sapiensGenome 132.92 124.4 125.1 142.44 115.63 32.58 176.44 236.01 1090.52
DESeq
batR. aegyptiacusTranscriptome 1.84 2.82 1.0 8.33 6.48 11.27 3.22 4.3 2.75
DESeq
bat_genomeR. aegyptiacusGenome 12.03 19.17 6.69 5.92 8.93 23.5 9.0 14.27 11.13

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 132.92 142.44 176.44 0.1 0.41 0.31
7h 124.4 115.63 236.01 -0.11 0.92 1.03
23h 125.1 32.58 1090.52 -1.94 3.12 5.06

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 132.92 124.4 125.1 -0.1 -0.09 0.01
Ebov 142.44 115.63 32.58 -0.3 -2.13 -1.83
Marv 176.44 236.01 1090.52 0.42 2.63 2.21

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.84 8.33 3.22 2.18 0.81 -1.37
7h 2.82 6.48 4.3 1.2 0.61 -0.59
23h 1.0 11.27 2.75 3.49 1.46 -2.03

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.84 2.82 1.0 0.62 -0.88 -1.5
Ebov 8.33 6.48 11.27 -0.36 0.44 0.8
Marv 3.22 4.3 2.75 0.42 -0.23 -0.64