GPX2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
GPX2	GPRP-2, GSHPx-G,GSHPX-GI	glutathione peroxidase 2		pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described.

The gene GPX2 is not expressed in bat cells but upregulated in human cells 23 h after Marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	30	26	34	25	31	19	40	63	235
Read_Max	R. aegyptiacus	Transcriptome	1	2	0	4	2	4	1	1	2
Read_Max	R. aegyptiacus	Genome	5	4	2	3	2	2	2	6	5
DESeq	H. sapiens	Genome	132.92	124.4	125.1	142.44	115.63	32.58	176.44	236.01	1090.52
DESeq	R. aegyptiacus	Transcriptome	1.84	2.82	1.0	8.33	6.48	11.27	3.22	4.3	2.75
DESeq	R. aegyptiacus	Genome	12.03	19.17	6.69	5.92	8.93	23.5	9.0	14.27	11.13

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	132.92	142.44	176.44	0.1	0.41	0.31
7h	124.4	115.63	236.01	-0.11	0.92	1.03
23h	125.1	32.58	1090.52	-1.94	3.12	5.06

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	132.92	124.4	125.1	-0.1	-0.09	0.01
Ebov	142.44	115.63	32.58	-0.3	-2.13	-1.83
Marv	176.44	236.01	1090.52	0.42	2.63	2.21

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1.84	8.33	3.22	2.18	0.81	-1.37
7h	2.82	6.48	4.3	1.2	0.61	-0.59
23h	1.0	11.27	2.75	3.49	1.46	-2.03

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1.84	2.82	1.0	0.62	-0.88	-1.5
Ebov	8.33	6.48	11.27	-0.36	0.44	0.8
Marv	3.22	4.3	2.75	0.42	-0.23	-0.64

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material