NR4A3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NR4A3	CHN, CSMF, MINOR, NM_173199, NOR1, NP_775291, Q92570-2, TEC,CSMF, CHN	nuclear receptor subfamily 4, group A, member 3		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.

This gene is not expressed in human cells cells. In bat cells cells we found a slight expression in all probes.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	40	19	20	19	17	28	21	17	42
Read_Max	R. aegyptiacus	Transcriptome	40	30	22	14	9	34	20	21	44
Read_Max	R. aegyptiacus	Genome	44	16	18	28	8	18	18	19	42
DESeq	H. sapiens	Genome	12.16	9.16	16.89	15.83	5.88	161.54	10.65	6.6	9.7
DESeq	R. aegyptiacus	Transcriptome	311.85	186.17	185.45	106.3	84.23	247.37	153.4	86.1	185.56
DESeq	R. aegyptiacus	Genome	562.9	220.87	272.25	278.47	165.19	407.29	295.75	152.25	320.22

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	12.16	15.83	10.65	0.38	-0.19	-0.57
7h	9.16	5.88	6.6	-0.64	-0.47	0.17
23h	16.89	161.54	9.7	3.26	-0.8	-4.06

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	12.16	9.16	16.89	-0.41	0.47	0.88
Ebov	15.83	5.88	161.54	-1.43	3.35	4.78
Marv	10.65	6.6	9.7	-0.69	-0.13	0.56

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	311.85	106.3	153.4	-1.55	-1.02	0.53
7h	186.17	84.23	86.1	-1.14	-1.11	0.03
23h	185.45	247.37	185.56	0.42	0.0	-0.41

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	311.85	186.17	185.45	-0.74	-0.75	-0.01
Ebov	106.3	84.23	247.37	-0.34	1.22	1.55
Marv	153.4	86.1	185.56	-0.83	0.27	1.11

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material