CREB5
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| CREB5 | CRE-BPa, CREBPA,H_GS165L15.1, CRE-BPA | cAMP responsive element binding protein 5 | NM_004904 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.
The CREB5 gene encodes a zinc finger protein that may dimerize with cJun or \update to form an active transcription factor. This gene is 9.5X up-regulated in human cells after an EBOV infection, whereas in bat cells only a slight up-regulation takes place. Its expression is not increased in Marburg-infected human cells cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 16 | 15 | 10 | 18 | 34 | 322 | 21 | 24 | 43 |
Read_Max |  | R. aegyptiacus | Transcriptome | 109 | 108 | 172 | 159 | 162 | 310 | 118 | 176 | 184 |
Read_Max |  | R. aegyptiacus | Genome | 128 | 170 | 155 | 110 | 140 | 199 | 109 | 232 | 218 |
DESeq | | H. sapiens | Genome | 425.18 | 334.5 | 226.37 | 433.32 | 419.67 | 7118.82 | 447.5 | 479.81 | 1484.14 |
DESeq | | R. aegyptiacus | Transcriptome | 574.82 | 578.29 | 843.86 | 761.0 | 752.23 | 1243.12 | 586.13 | 623.13 | 608.92 |
DESeq | | R. aegyptiacus | Genome | 2493.95 | 3313.05 | 3990.02 | 2234.68 | 3339.47 | 5469.67 | 2523.45 | 3195.57 | 3419.63 |