CREB5

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CREB5 CRE-BPa, CREBPA,H_GS165L15.1, CRE-BPA cAMP responsive element binding protein 5 NM_004904 pdf

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Description

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.

The CREB5 gene encodes a zinc finger protein that may dimerize with cJun or \update to form an active transcription factor. This gene is 9.5X up-regulated in human cells after an EBOV infection, whereas in bat cells only a slight up-regulation takes place. Its expression is not increased in Marburg-infected human cells cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome16 15 10 18 34 322 21 24 43
Read_Max
batR. aegyptiacusTranscriptome 109 108 172 159 162 310 118 176 184
Read_Max
bat_genomeR. aegyptiacusGenome 128 170 155 110 140 199 109 232 218
DESeq
humanH. sapiensGenome 425.18 334.5 226.37 433.32 419.67 7118.82 447.5 479.81 1484.14
DESeq
batR. aegyptiacusTranscriptome 574.82 578.29 843.86 761.0 752.23 1243.12 586.13 623.13 608.92
DESeq
bat_genomeR. aegyptiacusGenome 2493.95 3313.05 3990.02 2234.68 3339.47 5469.67 2523.45 3195.57 3419.63

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 425.18 433.32 447.5 0.03 0.07 0.05
7h 334.5 419.67 479.81 0.33 0.52 0.19
23h 226.37 7118.82 1484.14 4.97 2.71 -2.26

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 425.18 334.5 226.37 -0.35 -0.91 -0.56
Ebov 433.32 419.67 7118.82 -0.05 4.04 4.08
Marv 447.5 479.81 1484.14 0.1 1.73 1.63

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 574.82 761.0 586.13 0.4 0.03 -0.38
7h 578.29 752.23 623.13 0.38 0.11 -0.27
23h 843.86 1243.12 608.92 0.56 -0.47 -1.03

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 574.82 578.29 843.86 0.01 0.55 0.55
Ebov 761.0 752.23 1243.12 -0.02 0.71 0.72
Marv 586.13 623.13 608.92 0.09 0.06 -0.03