Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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CYR61

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
CYR61	CCN1, GIG1, IGFBP10,GIG1, CCN1	cysteine-rich, angiogenic inducer, 61	NM_001554	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The secreted protein encoded by this gene is growth factor-inducible andpromotes the adhesion of endothelial cells. The encoded protein interactswith several integrins and with heparan sulfate proteoglycan. This proteinalso plays a role in cell proliferation, differentiation, angiogenesis,apoptosis, and extracellular matrix formation.

Significant up-regulation in human cells cells after 23 h of Ebolainfection, otherwise low expression in human cells. There is a very highexpression in the bat cells homolog.}

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source		Species	Mapping on	Mock3h	Mock7h	Mock23h	EBOV3h	EBOV7h	EBOV23h	MARV3h	MARV7h	MARV23h
Read_Max		H. sapiens	Genome	42	52	20	63	48	476	103	78	40
Read_Max		R. aegyptiacus	Transcriptome	1838	2052	1762	1580	1335	2116	1415	1880	2172
Read_Max		R. aegyptiacus	Genome	2120	1687	1550	2081	1141	1285	1276	2384	2469
DESeq		H. sapiens	Genome	421.12	376.31	138.01	753.85	332.68	4271.17	972.07	619.7	422.89
DESeq		R. aegyptiacus	Transcriptome	11726.0	15689.51	16037.33	12634.48	11847.68	15530.06	12060.59	12589.11	13367.42
DESeq		R. aegyptiacus	Genome	16084.34	16702.13	21599.23	22022.86	16154.92	22022.27	17428.0	16781.91	18402.13

Human Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	421.12	753.85	972.07	0.84	1.21	0.37
7h	376.31	332.68	619.7	-0.18	0.72	0.9
23h	138.01	4271.17	422.89	4.95	1.62	-3.34

Human Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	421.12	376.31	138.01	-0.16	-1.61	-1.45
Ebov	753.85	332.68	4271.17	-1.18	2.5	3.68
Marv	972.07	619.7	422.89	-0.65	-1.2	-0.55

Bat Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	11726.0	12634.48	12060.59	0.11	0.04	-0.07
7h	15689.51	11847.68	12589.11	-0.41	-0.32	0.09
23h	16037.33	15530.06	13367.42	-0.05	-0.26	-0.22

Bat Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	11726.0	15689.51	16037.33	0.42	0.45	0.03
Ebov	12634.48	11847.68	15530.06	-0.09	0.3	0.39
Marv	12060.59	12589.11	13367.42	0.06	0.15	0.09