INHBA

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
INHBA FRP, EDF, Inhibin, Beta A inhibin, beta A pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.

The gene INHBA is not expressed in human cells and weakly expressed in bat cells datasets.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome3 2 1 6 4 5 5 3 9
Read_Max
batR. aegyptiacusTranscriptome 38 30 39 24 23 19 22 22 32
Read_Max
bat_genomeR. aegyptiacusGenome 36 21 24 24 22 9 18 24 32
DESeq
humanH. sapiensGenome 6.07 5.08 2.99 28.38 13.19 16.79 15.04 14.59 62.98
DESeq
batR. aegyptiacusTranscriptome 164.83 164.38 269.74 132.86 153.22 102.37 180.1 98.49 185.56
DESeq
bat_genomeR. aegyptiacusGenome 256.1 202.62 377.13 266.62 228.81 133.15 273.26 171.28 291.11

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6.07 28.38 15.04 2.23 1.31 -0.92
7h 5.08 13.19 14.59 1.38 1.52 0.15
23h 2.99 16.79 62.98 2.49 4.4 1.91

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6.07 5.08 2.99 -0.26 -1.02 -0.76
Ebov 28.38 13.19 16.79 -1.11 -0.76 0.35
Marv 15.04 14.59 62.98 -0.04 2.07 2.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 164.83 132.86 180.1 -0.31 0.13 0.44
7h 164.38 153.22 98.49 -0.1 -0.74 -0.64
23h 269.74 102.37 185.56 -1.4 -0.54 0.86

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 164.83 164.38 269.74 -0.0 0.71 0.71
Ebov 132.86 153.22 102.37 0.21 -0.38 -0.58
Marv 180.1 98.49 185.56 -0.87 0.04 0.91