SOCS2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SOCS2 A8K3D1, CIS2, NM_003877, NP_003868, O14508, O14542, O95102, Q9UKS5, SOCS2_HUMAN, SSI2, STATI2, uc001tcw.1,STATI2, SOCS-2, SSI-2, Cish2 suppressor of cytokine signaling 2 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens suppressor of cytokine signaling 2 (SOCS2), transcript variant 1, mRNA. This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. Very low expression.

We observed very low expression in all probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome6 4 3 7 3 16 9 5 3
Read_Max
batR. aegyptiacusTranscriptome 17 11 11 11 18 7 9 19 11
Read_Max
bat_genomeR. aegyptiacusGenome 14 13 11 13 10 5 13 20 26
DESeq
humanH. sapiensGenome 35.5 20.38 5.96 32.94 14.01 149.7 50.12 28.98 21.66
DESeq
batR. aegyptiacusTranscriptome 44.69 35.49 58.41 30.3 55.75 25.38 23.25 41.48 34.24
DESeq
bat_genomeR. aegyptiacusGenome 73.91 79.4 133.89 110.6 94.87 44.38 66.35 69.78 111.3

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 35.5 32.94 50.12 -0.11 0.5 0.61
7h 20.38 14.01 28.98 -0.54 0.51 1.05
23h 5.96 149.7 21.66 4.65 1.86 -2.79

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 35.5 20.38 5.96 -0.8 -2.57 -1.77
Ebov 32.94 14.01 149.7 -1.23 2.18 3.42
Marv 50.12 28.98 21.66 -0.79 -1.21 -0.42

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 44.69 30.3 23.25 -0.56 -0.94 -0.38
7h 35.49 55.75 41.48 0.65 0.23 -0.43
23h 58.41 25.38 34.24 -1.2 -0.77 0.43

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 44.69 35.49 58.41 -0.33 0.39 0.72
Ebov 30.3 55.75 25.38 0.88 -0.26 -1.14
Marv 23.25 41.48 34.24 0.84 0.56 -0.28