PCDH20

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PCDH20	PCDH13, FLJ22218	protocadherin 20	NM_022843	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.

Very low to no expression in human cells, but expressed moderately in bat cells homolog.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	5	6	3	10	4	3	8	3	6
Read_Max	R. aegyptiacus	Transcriptome	84	52	84	65	54	43	55	77	79
Read_Max	R. aegyptiacus	Genome	93	61	65	47	45	25	44	91	76
DESeq	H. sapiens	Genome	56.81	50.97	10.93	115.07	28.64	4.95	60.65	16.99	40.14
DESeq	R. aegyptiacus	Transcriptome	891.55	749.84	1165.12	892.86	858.46	636.17	912.06	817.29	943.94
DESeq	R. aegyptiacus	Genome	1077.68	998.48	1200.58	970.7	971.04	762.36	1095.29	917.44	1049.69

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	56.81	115.07	60.65	1.02	0.09	-0.92
7h	50.97	28.64	16.99	-0.83	-1.58	-0.75
23h	10.93	4.95	40.14	-1.14	1.88	3.02

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	56.81	50.97	10.93	-0.16	-2.38	-2.22
Ebov	115.07	28.64	4.95	-2.01	-4.54	-2.53
Marv	60.65	16.99	40.14	-1.84	-0.6	1.24

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	891.55	892.86	912.06	0.0	0.03	0.03
7h	749.84	858.46	817.29	0.2	0.12	-0.07
23h	1165.12	636.17	943.94	-0.87	-0.3	0.57

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	891.55	749.84	1165.12	-0.25	0.39	0.64
Ebov	892.86	858.46	636.17	-0.06	-0.49	-0.43
Marv	912.06	817.29	943.94	-0.16	0.05	0.21

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material