FMNL1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
FMNL1	C17orf1	formin-like 1	NM_005892	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens formin-like 1 (FMNL1), mRNA. his gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.

Low expression in both human cells and bat cells. Homolog contig in bat cells is not complete. However, same pattern of upregulation observed for human cells and bat cells in Ebola and Marburg infected cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	4	5	2	4	3	47	7	6	25
Read_Max	R. aegyptiacus	Transcriptome	10	4	7	6	8	17	4	10	15
Read_Max	R. aegyptiacus	Genome	9	7	7	4	4	6	4	13	20
DESeq	H. sapiens	Genome	34.49	40.78	34.76	32.94	18.88	514.21	52.76	51.36	397.88
DESeq	R. aegyptiacus	Transcriptome	27.88	19.15	48.64	30.3	38.23	63.88	25.47	36.53	97.22
DESeq	R. aegyptiacus	Genome	37.81	39.25	58.02	28.64	39.06	79.63	33.74	59.47	142.13

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	34.49	32.94	52.76	-0.07	0.61	0.68
7h	40.78	18.88	51.36	-1.11	0.33	1.44
23h	34.76	514.21	397.88	3.89	3.52	-0.37

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	34.49	40.78	34.76	0.24	0.01	-0.23
Ebov	32.94	18.88	514.21	-0.8	3.96	4.77
Marv	52.76	51.36	397.88	-0.04	2.91	2.95

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	27.88	30.3	25.47	0.12	-0.13	-0.25
7h	19.15	38.23	36.53	1.0	0.93	-0.07
23h	48.64	63.88	97.22	0.39	1.0	0.61

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	27.88	19.15	48.64	-0.54	0.8	1.34
Ebov	30.3	38.23	63.88	0.34	1.08	0.74
Marv	25.47	36.53	97.22	0.52	1.93	1.41

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material