FMNL1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FMNL1 C17orf1 formin-like 1 NM_005892 pdf

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Description

Homo sapiens formin-like 1 (FMNL1), mRNA. his gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.

Low expression in both human cells and bat cells. Homolog contig in bat cells is not complete. However, same pattern of upregulation observed for human cells and bat cells in Ebola and Marburg infected cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 5 2 4 3 47 7 6 25
Read_Max
batR. aegyptiacusTranscriptome 10 4 7 6 8 17 4 10 15
Read_Max
bat_genomeR. aegyptiacusGenome 9 7 7 4 4 6 4 13 20
DESeq
humanH. sapiensGenome 34.49 40.78 34.76 32.94 18.88 514.21 52.76 51.36 397.88
DESeq
batR. aegyptiacusTranscriptome 27.88 19.15 48.64 30.3 38.23 63.88 25.47 36.53 97.22
DESeq
bat_genomeR. aegyptiacusGenome 37.81 39.25 58.02 28.64 39.06 79.63 33.74 59.47 142.13

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 34.49 32.94 52.76 -0.07 0.61 0.68
7h 40.78 18.88 51.36 -1.11 0.33 1.44
23h 34.76 514.21 397.88 3.89 3.52 -0.37

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 34.49 40.78 34.76 0.24 0.01 -0.23
Ebov 32.94 18.88 514.21 -0.8 3.96 4.77
Marv 52.76 51.36 397.88 -0.04 2.91 2.95

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 27.88 30.3 25.47 0.12 -0.13 -0.25
7h 19.15 38.23 36.53 1.0 0.93 -0.07
23h 48.64 63.88 97.22 0.39 1.0 0.61

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 27.88 19.15 48.64 -0.54 0.8 1.34
Ebov 30.3 38.23 63.88 0.34 1.08 0.74
Marv 25.47 36.53 97.22 0.52 1.93 1.41