DLX2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DLX2 DLX2, TES-1, TES1,TES-1 distal-less homeobox 2 pdf

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Description

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.

The gene shows low-level expression slightly above noise in human cells and bat cells, but is upregulated in Ebola infected cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome3 4 4 2 2 31 2 4 3
Read_Max
batR. aegyptiacusTranscriptome 6 8 7 7 8 6 6 5 13
Read_Max
bat_genomeR. aegyptiacusGenome 10 11 7 9 9 4 10 8 9
DESeq
humanH. sapiensGenome 14.19 7.12 9.94 15.83 8.32 202.34 5.39 12.19 21.66
DESeq
batR. aegyptiacusTranscriptome 15.28 18.25 19.32 15.65 26.19 17.68 19.91 11.74 21.12
DESeq
bat_genomeR. aegyptiacusGenome 43.83 46.55 41.28 49.37 62.5 31.33 44.98 30.13 29.97

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 14.19 15.83 5.39 0.16 -1.4 -1.55
7h 7.12 8.32 12.19 0.22 0.78 0.55
23h 9.94 202.34 21.66 4.35 1.12 -3.22

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 14.19 7.12 9.94 -0.99 -0.51 0.48
Ebov 15.83 8.32 202.34 -0.93 3.68 4.6
Marv 5.39 12.19 21.66 1.18 2.01 0.83

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 15.28 15.65 19.91 0.03 0.38 0.35
7h 18.25 26.19 11.74 0.52 -0.64 -1.16
23h 19.32 17.68 21.12 -0.13 0.13 0.26

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 15.28 18.25 19.32 0.26 0.34 0.08
Ebov 15.65 26.19 17.68 0.74 0.18 -0.57
Marv 19.91 11.74 21.12 -0.76 0.09 0.85