NCF2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NCF2 B2R6Q1, NCF2_HUMAN, NM_001127651, NOXA2,p67phox neutrophil cytosolic factor 2 NM_000433 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodaltoncytosolic subunit of the multi-protein NADPH oxidase complex found inneutrophils. This oxidase produces a burst of superoxide which isdelivered to the lumen of the neutrophil phagosome. Mutations in thisgene, as well as in other NADPH oxidase subunits, can result inchronic granulomatous disease, a disease that causes recurrentinfections by catalase-positive organisms. Alternative splicingresults in multiple transcript variants encoding different isoforms.

For this gene only some expression in the human Marburg infected cells after23 h was observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome5 5 2 12 9 3 6 13 53
Read_Max
batR. aegyptiacusTranscriptome NA NA NA 1 1 5 2 2 2
Read_Max
bat_genomeR. aegyptiacusGenome 2 1 4 0 1 3 2 3 4
DESeq
humanH. sapiensGenome 23.33 27.52 18.87 55.75 32.71 28.63 50.12 71.34 485.96
DESeq
batR. aegyptiacusTranscriptome 1.0 1.0 1.0 1.92 3.19 15.11 3.22 2.65 2.75
DESeq
bat_genomeR. aegyptiacusGenome 5.16 0.91 11.16 0.0 6.7 19.58 7.87 6.34 8.56

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 23.33 55.75 50.12 1.26 1.1 -0.15
7h 27.52 32.71 71.34 0.25 1.37 1.12
23h 18.87 28.63 485.96 0.6 4.69 4.09

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 23.33 27.52 18.87 0.24 -0.31 -0.54
Ebov 55.75 32.71 28.63 -0.77 -0.96 -0.19
Marv 50.12 71.34 485.96 0.51 3.28 2.77

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.92 3.22 0.94 1.69 0.75
7h 1.0 3.19 2.65 1.67 1.41 -0.27
23h 1.0 15.11 2.75 3.92 1.46 -2.46

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 1.92 3.19 15.11 0.73 2.98 2.24
Marv 3.22 2.65 2.75 -0.28 -0.23 0.05