NCF2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NCF2	B2R6Q1, NCF2_HUMAN, NM_001127651, NOXA2,p67phox	neutrophil cytosolic factor 2	NM_000433	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodaltoncytosolic subunit of the multi-protein NADPH oxidase complex found inneutrophils. This oxidase produces a burst of superoxide which isdelivered to the lumen of the neutrophil phagosome. Mutations in thisgene, as well as in other NADPH oxidase subunits, can result inchronic granulomatous disease, a disease that causes recurrentinfections by catalase-positive organisms. Alternative splicingresults in multiple transcript variants encoding different isoforms.

For this gene only some expression in the human Marburg infected cells after23 h was observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	5	5	2	12	9	3	6	13	53
Read_Max	R. aegyptiacus	Transcriptome	NA	NA	NA	1	1	5	2	2	2
Read_Max	R. aegyptiacus	Genome	2	1	4	0	1	3	2	3	4
DESeq	H. sapiens	Genome	23.33	27.52	18.87	55.75	32.71	28.63	50.12	71.34	485.96
DESeq	R. aegyptiacus	Transcriptome	1.0	1.0	1.0	1.92	3.19	15.11	3.22	2.65	2.75
DESeq	R. aegyptiacus	Genome	5.16	0.91	11.16	0.0	6.7	19.58	7.87	6.34	8.56

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	23.33	55.75	50.12	1.26	1.1	-0.15
7h	27.52	32.71	71.34	0.25	1.37	1.12
23h	18.87	28.63	485.96	0.6	4.69	4.09

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	23.33	27.52	18.87	0.24	-0.31	-0.54
Ebov	55.75	32.71	28.63	-0.77	-0.96	-0.19
Marv	50.12	71.34	485.96	0.51	3.28	2.77

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1.0	1.92	3.22	0.94	1.69	0.75
7h	1.0	3.19	2.65	1.67	1.41	-0.27
23h	1.0	15.11	2.75	3.92	1.46	-2.46

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1.0	1.0	1.0	0.0	0.0	0.0
Ebov	1.92	3.19	15.11	0.73	2.98	2.24
Marv	3.22	2.65	2.75	-0.28	-0.23	0.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material