MAP1A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAP1A MAP1L microtubule-associated protein 1A NM_002373 pdf

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Description

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.

It seems to be downregulated in human cells 23 h after Ebola infection but is constantly expressed in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome77 160 95 96 179 18 107 243 244
Read_Max
batR. aegyptiacusTranscriptome 303 268 303 376 315 228 207 369 443
Read_Max
bat_genomeR. aegyptiacusGenome 341 386 238 250 243 134 176 416 470
DESeq
humanH. sapiensGenome 3127.56 4565.95 2717.37 2910.88 4577.91 318.14 3107.18 6371.02 8312.68
DESeq
batR. aegyptiacusTranscriptome 7494.21 7123.64 9335.98 8808.81 9059.58 6370.71 6274.97 8032.57 9418.11
DESeq
bat_genomeR. aegyptiacusGenome 8073.11 8743.52 9163.88 8522.97 9800.77 7837.68 7678.31 8130.08 10610.78

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3127.56 2910.88 3107.18 -0.1 -0.01 0.09
7h 4565.95 4577.91 6371.02 0.0 0.48 0.48
23h 2717.37 318.14 8312.68 -3.09 1.61 4.71

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3127.56 4565.95 2717.37 0.55 -0.2 -0.75
Ebov 2910.88 4577.91 318.14 0.65 -3.19 -3.85
Marv 3107.18 6371.02 8312.68 1.04 1.42 0.38

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7494.21 8808.81 6274.97 0.23 -0.26 -0.49
7h 7123.64 9059.58 8032.57 0.35 0.17 -0.17
23h 9335.98 6370.71 9418.11 -0.55 0.01 0.56

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7494.21 7123.64 9335.98 -0.07 0.32 0.39
Ebov 8808.81 9059.58 6370.71 0.04 -0.47 -0.51
Marv 6274.97 8032.57 9418.11 0.36 0.59 0.23