PLAU

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PLAU ATF, QPD, UPA, URK, u-PA, BDPLT5,URK plasminogen activator, urokinase NM_002658 pdf

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Description

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Low, but clear expression in human cells and down-regulated in Ebola- and Marburg-infected cells after 23 h. In the bat cells homolog, the expression is about 10-fold higher and also up-regulated in Ebola and Marburg-infected cells after 23 h.

Antisense to C10orf55 (see Section~\refapg:hg19.apg.00166).

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome14 33 11 19 29 6 23 23 2
Read_Max
batR. aegyptiacusTranscriptome 199 198 216 211 164 366 158 241 479
Read_Max
bat_genomeR. aegyptiacusGenome 208 209 173 195 136 194 129 280 484
DESeq
humanH. sapiensGenome 128.86 277.39 123.12 208.6 183.91 16.79 198.37 184.05 8.61
DESeq
batR. aegyptiacusTranscriptome 1285.57 1449.67 1899.27 1544.82 1526.46 2555.81 1305.85 1524.53 2753.71
DESeq
bat_genomeR. aegyptiacusGenome 1612.22 1835.41 2250.52 1896.96 1937.61 3216.53 1663.18 1864.22 3465.01

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 128.86 208.6 198.37 0.69 0.62 -0.07
7h 277.39 183.91 184.05 -0.59 -0.59 0.0
23h 123.12 16.79 8.61 -2.87 -3.84 -0.96

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 128.86 277.39 123.12 1.11 -0.07 -1.17
Ebov 208.6 183.91 16.79 -0.18 -3.64 -3.45
Marv 198.37 184.05 8.61 -0.11 -4.53 -4.42

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1285.57 1544.82 1305.85 0.27 0.02 -0.24
7h 1449.67 1526.46 1524.53 0.07 0.07 -0.0
23h 1899.27 2555.81 2753.71 0.43 0.54 0.11

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1285.57 1449.67 1899.27 0.17 0.56 0.39
Ebov 1544.82 1526.46 2555.81 -0.02 0.73 0.74
Marv 1305.85 1524.53 2753.71 0.22 1.08 0.85