AMOTL2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
AMOTL2 AK091040, KIAA0989, NM_016201, NP_057285, Q9Y2J4-2,LCCP angiomotin like 2 NM_016201 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Angiomotin binds angiostatin (circulating inhibitor of the formation of new blood vessels) and is required for migration and proliferation of endothelial cells during angiogenesis in zebrafish, Amotl2 promotes MAPK/ERK activation via c-SRC (Wang et al. 2011).

This gene is highly upregulated in in human cells cells 23 h after Ebola infection. In bat cells cells this gene is equally expressed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome125 102 41 124 113 1366 185 168 112
Read_Max
batR. aegyptiacusTranscriptome 782 630 641 484 514 577 440 706 829
Read_Max
bat_genomeR. aegyptiacusGenome 817 514 551 591 430 337 376 861 913
DESeq
humanH. sapiensGenome 2969.25 1956.1 915.39 2630.27 1718.76 23388.89 3162.45 2436.62 2358.37
DESeq
batR. aegyptiacusTranscriptome 5734.12 5600.54 6614.4 5381.47 5535.58 5387.8 4676.44 5655.57 5970.89
DESeq
bat_genomeR. aegyptiacusGenome 8914.45 8088.21 9506.43 9312.96 8657.85 8258.02 7717.66 8424.26 9119.3

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2969.25 2630.27 3162.45 -0.17 0.09 0.27
7h 1956.1 1718.76 2436.62 -0.19 0.32 0.5
23h 915.39 23388.89 2358.37 4.68 1.37 -3.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2969.25 1956.1 915.39 -0.6 -1.7 -1.1
Ebov 2630.27 1718.76 23388.89 -0.61 3.15 3.77
Marv 3162.45 2436.62 2358.37 -0.38 -0.42 -0.05

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5734.12 5381.47 4676.44 -0.09 -0.29 -0.2
7h 5600.54 5535.58 5655.57 -0.02 0.01 0.03
23h 6614.4 5387.8 5970.89 -0.3 -0.15 0.15

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5734.12 5600.54 6614.4 -0.03 0.21 0.24
Ebov 5381.47 5535.58 5387.8 0.04 0.0 -0.04
Marv 4676.44 5655.57 5970.89 0.27 0.35 0.08