TDO2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TDO2 TDO, TPH2 tryptophan 2,3-dioxygenase NM_005651 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens tryptophan 2,3-dioxygenase (TDO2), mRNA. This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Very low expression in human cells and no homolog found in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2 4 4 4 9 2 8 8 2
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 0 2 0 0 0 0 0 0 0
DESeq
humanH. sapiensGenome 11.15 24.46 18.87 7.84 34.33 2.32 19.42 28.98 9.7
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 0.0 1.83 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 11.15 7.84 19.42 -0.51 0.8 1.31
7h 24.46 34.33 28.98 0.49 0.24 -0.24
23h 18.87 2.32 9.7 -3.02 -0.96 2.06

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 11.15 24.46 18.87 1.13 0.76 -0.37
Ebov 7.84 34.33 2.32 2.13 -1.76 -3.89
Marv 19.42 28.98 9.7 0.58 -1.0 -1.58

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA