CLEC18A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CLEC18A MRCL, MRCL1, MRLP2 C-type lectin domain family 18, member A NM_182619 pdf

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Description

This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis.

There is a transcript overlapping the CLEC18C gene, a kind of fusion transcript. Upregulated in Ebola infected cells in human cells after 23 h, with intron expression typical of that data set.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 4 6 2 7 31 3 3 6
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 7 7 10 4 4 4 3 16 12
DESeq
humanH. sapiensGenome 5.06 8.14 10.93 3.28 4.25 57.58 4.51 5.8 7.52
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 37.81 76.67 200.84 29.62 63.62 41.77 22.49 130.04 112.16

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5.06 3.28 4.51 -0.63 -0.17 0.46
7h 8.14 4.25 5.8 -0.94 -0.49 0.45
23h 10.93 57.58 7.52 2.4 -0.54 -2.94

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5.06 8.14 10.93 0.69 1.11 0.43
Ebov 3.28 4.25 57.58 0.37 4.13 3.76
Marv 4.51 5.8 7.52 0.36 0.74 0.37

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA