NUDT7

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NUDT7		nudix (nucleoside diphosphate linked moiety X)-type motif 7		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules.

This gene is upregulated in Ebola and Marburg infected human cells cells after 7 h but not after 23 h. No credible homolog in bat cells was found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	5	5	5	10	15	3	6	16	5
Read_Max	R. aegyptiacus	Transcriptome	40	40	45	34	35	32	26	41	47
Read_Max	R. aegyptiacus	Genome	40	36	39	35	29	17	27	55	49
DESeq	H. sapiens	Genome	40.58	61.17	59.58	61.46	61.97	3.63	49.25	53.76	42.32
DESeq	R. aegyptiacus	Transcriptome	90.05	99.03	156.14	112.71	141.17	119.05	100.0	141.46	132.21
DESeq	R. aegyptiacus	Genome	133.21	158.81	194.15	150.1	188.63	152.73	124.82	191.1	163.53

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	40.58	61.46	49.25	0.6	0.28	-0.32
7h	61.17	61.97	53.76	0.02	-0.19	-0.21
23h	59.58	3.63	42.32	-4.04	-0.49	3.54

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	40.58	61.17	59.58	0.59	0.55	-0.04
Ebov	61.46	61.97	3.63	0.01	-4.08	-4.09
Marv	49.25	53.76	42.32	0.13	-0.22	-0.35

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	90.05	112.71	100.0	0.32	0.15	-0.17
7h	99.03	141.17	141.46	0.51	0.51	0.0
23h	156.14	119.05	132.21	-0.39	-0.24	0.15

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	90.05	99.03	156.14	0.14	0.79	0.66
Ebov	112.71	141.17	119.05	0.32	0.08	-0.25
Marv	100.0	141.46	132.21	0.5	0.4	-0.1

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material