NR4A1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| NR4A1 | HMR, N10, TR3, NP10, GFRP1, NAK-1, NGFIB, NUR77,TR3 | nuclear receptor subfamily 4, group A, member 1 |  |
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Description
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
The NR4A1 (Nur77) transcription factor is a member of the Nur subfamily of the orphan nuclear receptor superfamily. This gene is highly up-regulated in humans (17.4X, read\_max=366) and very rarely transcribed in bats (read\_max=8). As transcriptional activity is not regulated by endogenous ligands, changes of expression levels, post-translational modifications and subcellular localization regulate its activity [Campos-Melo et al., Front Mol Neurosci, 2013, 6:44]. NR4A1 and other Nur proteins are also involved in regulation of cytokine and growth factor signaling in inflammatory response [McMorrow and Murphy, Biochem Soc Trans, 2011, 39:688-693]. NR4A receptors are rapidly induced by a variety of cytokines, suggesting that they may act as transcriptional mediators of inflammatory signals by regulation of several target genes [McMorrow and Murphy, Biochem Soc Trans, 2011, 39:688-693]. In addition, it has been shown that NR4A proteins may be expressed by macrophages to reduce lipid loading as well as the inflammatory response of the cells [Bonta et al., Arterioscler Thromb Vasc Biol}, 2006, 26:2288-2294].
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 13 | 20 | 29 | 13 | 21 | 366 | 17 | 26 | 50 |
Read_Max |  | R. aegyptiacus | Transcriptome | 8 | 8 | 2 | 2 | 2 | 4 | 2 | 1 | 3 |
Read_Max |  | R. aegyptiacus | Genome | 10 | 4 | 4 | 6 | 2 | 3 | 2 | 5 | 4 |
DESeq | | H. sapiens | Genome | 176.56 | 225.37 | 376.29 | 229.14 | 234.32 | 4954.13 | 202.76 | 276.78 | 517.49 |
DESeq | | R. aegyptiacus | Transcriptome | 43.01 | 11.89 | 5.89 | 8.33 | 6.48 | 22.81 | 7.67 | 4.3 | 9.75 |
DESeq | | R. aegyptiacus | Genome | 67.89 | 22.82 | 25.66 | 19.75 | 15.63 | 33.94 | 5.62 | 11.1 | 20.55 |