NR4A1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NR4A1 HMR, N10, TR3, NP10, GFRP1, NAK-1, NGFIB, NUR77,TR3 nuclear receptor subfamily 4, group A, member 1 pdf

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Description

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

The NR4A1 (Nur77) transcription factor is a member of the Nur subfamily of the orphan nuclear receptor superfamily. This gene is highly up-regulated in humans (17.4X, read\_max=366) and very rarely transcribed in bats (read\_max=8). As transcriptional activity is not regulated by endogenous ligands, changes of expression levels, post-translational modifications and subcellular localization regulate its activity [Campos-Melo et al., Front Mol Neurosci, 2013, 6:44]. NR4A1 and other Nur proteins are also involved in regulation of cytokine and growth factor signaling in inflammatory response [McMorrow and Murphy, Biochem Soc Trans, 2011, 39:688-693]. NR4A receptors are rapidly induced by a variety of cytokines, suggesting that they may act as transcriptional mediators of inflammatory signals by regulation of several target genes [McMorrow and Murphy, Biochem Soc Trans, 2011, 39:688-693]. In addition, it has been shown that NR4A proteins may be expressed by macrophages to reduce lipid loading as well as the inflammatory response of the cells [Bonta et al., Arterioscler Thromb Vasc Biol}, 2006, 26:2288-2294].

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome13 20 29 13 21 366 17 26 50
Read_Max
batR. aegyptiacusTranscriptome 8 8 2 2 2 4 2 1 3
Read_Max
bat_genomeR. aegyptiacusGenome 10 4 4 6 2 3 2 5 4
DESeq
humanH. sapiensGenome 176.56 225.37 376.29 229.14 234.32 4954.13 202.76 276.78 517.49
DESeq
batR. aegyptiacusTranscriptome 43.01 11.89 5.89 8.33 6.48 22.81 7.67 4.3 9.75
DESeq
bat_genomeR. aegyptiacusGenome 67.89 22.82 25.66 19.75 15.63 33.94 5.62 11.1 20.55

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 176.56 229.14 202.76 0.38 0.2 -0.18
7h 225.37 234.32 276.78 0.06 0.3 0.24
23h 376.29 4954.13 517.49 3.72 0.46 -3.26

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 176.56 225.37 376.29 0.35 1.09 0.74
Ebov 229.14 234.32 4954.13 0.03 4.43 4.4
Marv 202.76 276.78 517.49 0.45 1.35 0.9

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 43.01 8.33 7.67 -2.37 -2.49 -0.12
7h 11.89 6.48 4.3 -0.88 -1.47 -0.59
23h 5.89 22.81 9.75 1.95 0.73 -1.23

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 43.01 11.89 5.89 -1.85 -2.87 -1.01
Ebov 8.33 6.48 22.81 -0.36 1.45 1.82
Marv 7.67 4.3 9.75 -0.83 0.35 1.18