HSPB8

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HSPB8 CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22,H11, HspB8 heat shock 22kDa protein 8 NM_014365 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

No homolog in bat cells was found, but expression in human cells is medium. In Ebola infected cells after 23 h this gene is 7fold, in Marburg infected cells after 23 h it is slightly upregulated.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome18 19 14 27 25 210 38 42 75
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 0 2 0 1 0 0 0 0 2
DESeq
humanH. sapiensGenome 168.44 151.94 95.32 232.56 180.66 2053.84 242.23 279.17 774.1
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 0.0 1.83 0.0 1.97 0.0 0.0 0.0 0.0 2.57

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 168.44 232.56 242.23 0.47 0.52 0.06
7h 151.94 180.66 279.17 0.25 0.88 0.63
23h 95.32 2053.84 774.1 4.43 3.02 -1.41

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 168.44 151.94 95.32 -0.15 -0.82 -0.67
Ebov 232.56 180.66 2053.84 -0.36 3.14 3.51
Marv 242.23 279.17 774.1 0.2 1.68 1.47

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA