FOSL2
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| FOSL2 | FRA2, FLJ23306 | FOS-like antigen 2 | NM_005253 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
In general, a low expression is observed in human cells samples, however, there was a significant up-regulation in human cells Ebola-infected cells after 23 h. In the bat cells homolog, the expression levels are roughly 100x higher than in human cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 13 | 12 | 10 | 10 | 11 | 182 | 18 | 15 | 26 |
Read_Max |  | R. aegyptiacus | Transcriptome | 785 | 654 | 657 | 615 | 581 | 750 | 551 | 687 | 717 |
Read_Max |  | R. aegyptiacus | Genome | 1331 | 916 | 793 | 830 | 762 | 738 | 859 | 1423 | 1196 |
DESeq | | H. sapiens | Genome | 165.4 | 156.02 | 122.12 | 110.51 | 117.25 | 2293.34 | 213.28 | 201.64 | 418.54 |
DESeq | | R. aegyptiacus | Transcriptome | 3649.73 | 3355.82 | 3654.62 | 3093.21 | 3153.76 | 3659.35 | 3342.67 | 2787.8 | 2851.68 |
DESeq | | R. aegyptiacus | Genome | 9984.39 | 8771.81 | 10135.72 | 9704.0 | 9263.91 | 10290.55 | 10119.66 | 8535.27 | 8090.16 |