FOSL2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FOSL2 FRA2, FLJ23306 FOS-like antigen 2 NM_005253 pdf

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Description

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

In general, a low expression is observed in human cells samples, however, there was a significant up-regulation in human cells Ebola-infected cells after 23 h. In the bat cells homolog, the expression levels are roughly 100x higher than in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome13 12 10 10 11 182 18 15 26
Read_Max
batR. aegyptiacusTranscriptome 785 654 657 615 581 750 551 687 717
Read_Max
bat_genomeR. aegyptiacusGenome 1331 916 793 830 762 738 859 1423 1196
DESeq
humanH. sapiensGenome 165.4 156.02 122.12 110.51 117.25 2293.34 213.28 201.64 418.54
DESeq
batR. aegyptiacusTranscriptome 3649.73 3355.82 3654.62 3093.21 3153.76 3659.35 3342.67 2787.8 2851.68
DESeq
bat_genomeR. aegyptiacusGenome 9984.39 8771.81 10135.72 9704.0 9263.91 10290.55 10119.66 8535.27 8090.16

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 165.4 110.51 213.28 -0.58 0.37 0.95
7h 156.02 117.25 201.64 -0.41 0.37 0.78
23h 122.12 2293.34 418.54 4.23 1.78 -2.45

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 165.4 156.02 122.12 -0.08 -0.44 -0.35
Ebov 110.51 117.25 2293.34 0.09 4.38 4.29
Marv 213.28 201.64 418.54 -0.08 0.97 1.05

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3649.73 3093.21 3342.67 -0.24 -0.13 0.11
7h 3355.82 3153.76 2787.8 -0.09 -0.27 -0.18
23h 3654.62 3659.35 2851.68 0.0 -0.36 -0.36

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3649.73 3355.82 3654.62 -0.12 0.0 0.12
Ebov 3093.21 3153.76 3659.35 0.03 0.24 0.21
Marv 3342.67 2787.8 2851.68 -0.26 -0.23 0.03