DPYSL2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DPYSL2	DRP2, N2A3, CRMP2, DRP-2, ULIP2, CRMP-2, DHPRP2, ULIP-2,DRP-2, DRP2	dihydropyrimidinase-like 2	NM_001386	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Well expressed in human cells cells, but significantly down-regulated in cells infected with Ebola after 23 h and slightly up-regulated in cells infected with Marburg. Generally well expressed in bat cells homolog.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	285	242	268	165	251	50	219	281	502
Read_Max	R. aegyptiacus	Transcriptome	233	198	120	200	162	150	130	237	206
Read_Max	R. aegyptiacus	Genome	258	243	196	215	185	107	160	339	306
DESeq	H. sapiens	Genome	5495.06	4813.78	5341.4	3588.45	3713.75	620.8	3395.78	3837.88	10490.64
DESeq	R. aegyptiacus	Transcriptome	1861.91	1759.2	1399.66	1701.4	1679.77	1463.83	1620.66	1728.6	1754.79
DESeq	R. aegyptiacus	Genome	3997.02	3726.49	3106.33	4034.86	3845.08	3450.2	3871.76	3764.11	3875.12

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5495.06	3588.45	3395.78	-0.61	-0.69	-0.08
7h	4813.78	3713.75	3837.88	-0.37	-0.33	0.05
23h	5341.4	620.8	10490.64	-3.11	0.97	4.08

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5495.06	4813.78	5341.4	-0.19	-0.04	0.15
Ebov	3588.45	3713.75	620.8	0.05	-2.53	-2.58
Marv	3395.78	3837.88	10490.64	0.18	1.63	1.45

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1861.91	1701.4	1620.66	-0.13	-0.2	-0.07
7h	1759.2	1679.77	1728.6	-0.07	-0.03	0.04
23h	1399.66	1463.83	1754.79	0.06	0.33	0.26

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1861.91	1759.2	1399.66	-0.08	-0.41	-0.33
Ebov	1701.4	1679.77	1463.83	-0.02	-0.22	-0.2
Marv	1620.66	1728.6	1754.79	0.09	0.11	0.02

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material