DPYSL2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DPYSL2 DRP2, N2A3, CRMP2, DRP-2, ULIP2, CRMP-2, DHPRP2, ULIP-2,DRP-2, DRP2 dihydropyrimidinase-like 2 NM_001386 pdf

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Description

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Well expressed in human cells cells, but significantly down-regulated in cells infected with Ebola after 23 h and slightly up-regulated in cells infected with Marburg. Generally well expressed in bat cells homolog.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome285 242 268 165 251 50 219 281 502
Read_Max
batR. aegyptiacusTranscriptome 233 198 120 200 162 150 130 237 206
Read_Max
bat_genomeR. aegyptiacusGenome 258 243 196 215 185 107 160 339 306
DESeq
humanH. sapiensGenome 5495.06 4813.78 5341.4 3588.45 3713.75 620.8 3395.78 3837.88 10490.64
DESeq
batR. aegyptiacusTranscriptome 1861.91 1759.2 1399.66 1701.4 1679.77 1463.83 1620.66 1728.6 1754.79
DESeq
bat_genomeR. aegyptiacusGenome 3997.02 3726.49 3106.33 4034.86 3845.08 3450.2 3871.76 3764.11 3875.12

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5495.06 3588.45 3395.78 -0.61 -0.69 -0.08
7h 4813.78 3713.75 3837.88 -0.37 -0.33 0.05
23h 5341.4 620.8 10490.64 -3.11 0.97 4.08

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5495.06 4813.78 5341.4 -0.19 -0.04 0.15
Ebov 3588.45 3713.75 620.8 0.05 -2.53 -2.58
Marv 3395.78 3837.88 10490.64 0.18 1.63 1.45

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1861.91 1701.4 1620.66 -0.13 -0.2 -0.07
7h 1759.2 1679.77 1728.6 -0.07 -0.03 0.04
23h 1399.66 1463.83 1754.79 0.06 0.33 0.26

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1861.91 1759.2 1399.66 -0.08 -0.41 -0.33
Ebov 1701.4 1679.77 1463.83 -0.02 -0.22 -0.2
Marv 1620.66 1728.6 1754.79 0.09 0.11 0.02