ABCA1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ABCA1 TGD ATP-binding cassette, sub-family A (ABC1), member 1 NM_005502 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The membrane-associated protein encoded by this gene (ABCA1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

For this gene, in human cells a strong downregulation (17x) for the 23 h Ebola infected probes was detected. The expression of the wildtype probes did only differ slightly between the different time points. For the Marburg infected cells a constant downregualtion was observed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome381 344 295 329 397 36 367 270 174
Read_Max
batR. aegyptiacusTranscriptome 12 14 8 13 16 17 12 22 14
Read_Max
bat_genomeR. aegyptiacusGenome 14 21 9 14 11 12 12 25 14
DESeq
humanH. sapiensGenome 16376.62 13094.13 12507.61 13648.13 12529.38 818.19 12495.91 9310.24 7463.46
DESeq
batR. aegyptiacusTranscriptome 250.52 186.17 161.02 206.11 245.21 312.81 181.21 248.04 208.31
DESeq
bat_genomeR. aegyptiacusGenome 360.94 272.89 185.22 274.52 272.34 387.71 251.9 294.18 261.14

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 16376.62 13648.13 12495.91 -0.26 -0.39 -0.13
7h 13094.13 12529.38 9310.24 -0.06 -0.49 -0.43
23h 12507.61 818.19 7463.46 -3.93 -0.74 3.19

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 16376.62 13094.13 12507.61 -0.32 -0.39 -0.07
Ebov 13648.13 12529.38 818.19 -0.12 -4.06 -3.94
Marv 12495.91 9310.24 7463.46 -0.42 -0.74 -0.32

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 250.52 206.11 181.21 -0.28 -0.47 -0.19
7h 186.17 245.21 248.04 0.4 0.41 0.02
23h 161.02 312.81 208.31 0.96 0.37 -0.59

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 250.52 186.17 161.02 -0.43 -0.64 -0.21
Ebov 206.11 245.21 312.81 0.25 0.6 0.35
Marv 181.21 248.04 208.31 0.45 0.2 -0.25