ABCA1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ABCA1	TGD	ATP-binding cassette, sub-family A (ABC1), member 1	NM_005502	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The membrane-associated protein encoded by this gene (ABCA1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

For this gene, in human cells a strong downregulation (17x) for the 23 h Ebola infected probes was detected. The expression of the wildtype probes did only differ slightly between the different time points. For the Marburg infected cells a constant downregualtion was observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	381	344	295	329	397	36	367	270	174
Read_Max	R. aegyptiacus	Transcriptome	12	14	8	13	16	17	12	22	14
Read_Max	R. aegyptiacus	Genome	14	21	9	14	11	12	12	25	14
DESeq	H. sapiens	Genome	16376.62	13094.13	12507.61	13648.13	12529.38	818.19	12495.91	9310.24	7463.46
DESeq	R. aegyptiacus	Transcriptome	250.52	186.17	161.02	206.11	245.21	312.81	181.21	248.04	208.31
DESeq	R. aegyptiacus	Genome	360.94	272.89	185.22	274.52	272.34	387.71	251.9	294.18	261.14

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	16376.62	13648.13	12495.91	-0.26	-0.39	-0.13
7h	13094.13	12529.38	9310.24	-0.06	-0.49	-0.43
23h	12507.61	818.19	7463.46	-3.93	-0.74	3.19

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	16376.62	13094.13	12507.61	-0.32	-0.39	-0.07
Ebov	13648.13	12529.38	818.19	-0.12	-4.06	-3.94
Marv	12495.91	9310.24	7463.46	-0.42	-0.74	-0.32

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	250.52	206.11	181.21	-0.28	-0.47	-0.19
7h	186.17	245.21	248.04	0.4	0.41	0.02
23h	161.02	312.81	208.31	0.96	0.37	-0.59

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	250.52	186.17	161.02	-0.43	-0.64	-0.21
Ebov	206.11	245.21	312.81	0.25	0.6	0.35
Marv	181.21	248.04	208.31	0.45	0.2	-0.25

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material